ES2128960B1 - PHARMACOLOGICALLY ACTIVE COMPOUNDS OF FLUOROPHENYL-TRIAZINS AND PYRIMIDINES DERIVATIVES IN THE CENTRAL NERVOUS SYSTEM. - Google Patents
PHARMACOLOGICALLY ACTIVE COMPOUNDS OF FLUOROPHENYL-TRIAZINS AND PYRIMIDINES DERIVATIVES IN THE CENTRAL NERVOUS SYSTEM.Info
- Publication number
- ES2128960B1 ES2128960B1 ES9602667A ES9602667A ES2128960B1 ES 2128960 B1 ES2128960 B1 ES 2128960B1 ES 9602667 A ES9602667 A ES 9602667A ES 9602667 A ES9602667 A ES 9602667A ES 2128960 B1 ES2128960 B1 ES 2128960B1
- Authority
- ES
- Spain
- Prior art keywords
- nervous system
- central nervous
- fluorophenyl
- pharmacologically active
- active compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de fluorofenil-triazinas y pirimidinas compuestos farmacológicamente activos en el sistema nervioso central.La presente invención se refiere a nuevos compuestos derivados de m-fluorofeniltriazinas y m-fluorofenilpirimidinas tetra o pentahalogenados en el anillo bencénico y sus sales fisiológicamente aceptables de fórmula general I, a los procedimientos para su preparación, y a su utilización como medicamentos, así como a las composiciones farmacéuticas que los contienen. Los compuestos objeto de la invención pueden ser igualmente utilizados en la industria farmacéutica como intermediarios y en la preparación de medicamentos. Estos compuestos presentan ciertas actividades farmacológicas interesantes, y en particular han mostrado ser inhibidores de la liberación del glutamato en el sistema nervioso central (SNC).Derivatives of fluorophenyl-triazines and pyrimidines pharmacologically active compounds in the central nervous system. The present invention relates to new compounds derived from tetrabenzlop m-fluorophenyltriazines and m-fluorophenylpyrimidines and their physiologically acceptable salts of general formula I, to the procedures for their preparation, and to their use as medicines, as well as to the pharmaceutical compositions that contain them. The compounds object of the invention can also be used in the pharmaceutical industry as intermediaries and in the preparation of medicines. These compounds have certain interesting pharmacological activities, and in particular have been shown to be inhibitors of glutamate release in the central nervous system (CNS).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9514354A FR2741879A1 (en) | 1995-12-05 | 1995-12-05 | FLUOROPHENYL-TRIAZINE AND PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2128960A1 ES2128960A1 (en) | 1999-05-16 |
ES2128960B1 true ES2128960B1 (en) | 2000-01-16 |
Family
ID=9485150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9602667A Expired - Lifetime ES2128960B1 (en) | 1995-12-05 | 1996-12-05 | PHARMACOLOGICALLY ACTIVE COMPOUNDS OF FLUOROPHENYL-TRIAZINS AND PYRIMIDINES DERIVATIVES IN THE CENTRAL NERVOUS SYSTEM. |
Country Status (4)
Country | Link |
---|---|
AU (1) | AU1194397A (en) |
ES (1) | ES2128960B1 (en) |
FR (1) | FR2741879A1 (en) |
WO (1) | WO1997020827A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9625795D0 (en) * | 1996-12-12 | 1997-01-29 | Smithkline Beecham Plc | Novel treatment |
GB9726987D0 (en) | 1997-12-22 | 1998-02-18 | Glaxo Group Ltd | Compounds |
CA2334937C (en) * | 1998-12-14 | 2004-09-21 | Torrent Pharmaceuticals Ltd. | An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
KR101379625B1 (en) * | 2006-01-13 | 2014-03-31 | 다우 아그로사이언시즈 엘엘씨 | 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK153787C (en) * | 1979-06-01 | 1989-01-16 | Wellcome Found | METHOD OF ANALOGUE FOR THE PREPARATION OF SUBSTITUTED 3,5-DIAMINO-6-PHENYL-1,2,4-TRIAZINES AND ALFA-CYANOBENZYLIDEEN-AMINOGUANIDE COMPOUNDS FOR USE AS INTERMEDIATES |
GB9012316D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
GB9012311D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
-
1995
- 1995-12-05 FR FR9514354A patent/FR2741879A1/en active Pending
-
1996
- 1996-12-04 WO PCT/EP1996/005593 patent/WO1997020827A1/en active Application Filing
- 1996-12-04 AU AU11943/97A patent/AU1194397A/en not_active Abandoned
- 1996-12-05 ES ES9602667A patent/ES2128960B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2128960A1 (en) | 1999-05-16 |
AU1194397A (en) | 1997-06-27 |
WO1997020827A1 (en) | 1997-06-12 |
FR2741879A1 (en) | 1997-06-06 |
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Legal Events
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EC2A | Search report published |
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