ES2128960B1 - PHARMACOLOGICALLY ACTIVE COMPOUNDS OF FLUOROPHENYL-TRIAZINS AND PYRIMIDINES DERIVATIVES IN THE CENTRAL NERVOUS SYSTEM. - Google Patents

PHARMACOLOGICALLY ACTIVE COMPOUNDS OF FLUOROPHENYL-TRIAZINS AND PYRIMIDINES DERIVATIVES IN THE CENTRAL NERVOUS SYSTEM.

Info

Publication number
ES2128960B1
ES2128960B1 ES9602667A ES9602667A ES2128960B1 ES 2128960 B1 ES2128960 B1 ES 2128960B1 ES 9602667 A ES9602667 A ES 9602667A ES 9602667 A ES9602667 A ES 9602667A ES 2128960 B1 ES2128960 B1 ES 2128960B1
Authority
ES
Spain
Prior art keywords
nervous system
central nervous
fluorophenyl
pharmacologically active
active compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9602667A
Other languages
Spanish (es)
Other versions
ES2128960A1 (en
Inventor
Jover Antoni Torrens
Constansa Jordi Frigola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2128960A1 publication Critical patent/ES2128960A1/en
Application granted granted Critical
Publication of ES2128960B1 publication Critical patent/ES2128960B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivados de fluorofenil-triazinas y pirimidinas compuestos farmacológicamente activos en el sistema nervioso central.La presente invención se refiere a nuevos compuestos derivados de m-fluorofeniltriazinas y m-fluorofenilpirimidinas tetra o pentahalogenados en el anillo bencénico y sus sales fisiológicamente aceptables de fórmula general I, a los procedimientos para su preparación, y a su utilización como medicamentos, así como a las composiciones farmacéuticas que los contienen. Los compuestos objeto de la invención pueden ser igualmente utilizados en la industria farmacéutica como intermediarios y en la preparación de medicamentos. Estos compuestos presentan ciertas actividades farmacológicas interesantes, y en particular han mostrado ser inhibidores de la liberación del glutamato en el sistema nervioso central (SNC).Derivatives of fluorophenyl-triazines and pyrimidines pharmacologically active compounds in the central nervous system. The present invention relates to new compounds derived from tetrabenzlop m-fluorophenyltriazines and m-fluorophenylpyrimidines and their physiologically acceptable salts of general formula I, to the procedures for their preparation, and to their use as medicines, as well as to the pharmaceutical compositions that contain them. The compounds object of the invention can also be used in the pharmaceutical industry as intermediaries and in the preparation of medicines. These compounds have certain interesting pharmacological activities, and in particular have been shown to be inhibitors of glutamate release in the central nervous system (CNS).

ES9602667A 1995-12-05 1996-12-05 PHARMACOLOGICALLY ACTIVE COMPOUNDS OF FLUOROPHENYL-TRIAZINS AND PYRIMIDINES DERIVATIVES IN THE CENTRAL NERVOUS SYSTEM. Expired - Lifetime ES2128960B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9514354A FR2741879A1 (en) 1995-12-05 1995-12-05 FLUOROPHENYL-TRIAZINE AND PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
ES2128960A1 ES2128960A1 (en) 1999-05-16
ES2128960B1 true ES2128960B1 (en) 2000-01-16

Family

ID=9485150

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9602667A Expired - Lifetime ES2128960B1 (en) 1995-12-05 1996-12-05 PHARMACOLOGICALLY ACTIVE COMPOUNDS OF FLUOROPHENYL-TRIAZINS AND PYRIMIDINES DERIVATIVES IN THE CENTRAL NERVOUS SYSTEM.

Country Status (4)

Country Link
AU (1) AU1194397A (en)
ES (1) ES2128960B1 (en)
FR (1) FR2741879A1 (en)
WO (1) WO1997020827A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9625795D0 (en) * 1996-12-12 1997-01-29 Smithkline Beecham Plc Novel treatment
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
CA2334937C (en) * 1998-12-14 2004-09-21 Torrent Pharmaceuticals Ltd. An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
KR101379625B1 (en) * 2006-01-13 2014-03-31 다우 아그로사이언시즈 엘엘씨 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK153787C (en) * 1979-06-01 1989-01-16 Wellcome Found METHOD OF ANALOGUE FOR THE PREPARATION OF SUBSTITUTED 3,5-DIAMINO-6-PHENYL-1,2,4-TRIAZINES AND ALFA-CYANOBENZYLIDEEN-AMINOGUANIDE COMPOUNDS FOR USE AS INTERMEDIATES
GB9012316D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds

Also Published As

Publication number Publication date
ES2128960A1 (en) 1999-05-16
AU1194397A (en) 1997-06-27
WO1997020827A1 (en) 1997-06-12
FR2741879A1 (en) 1997-06-06

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