NO912341L - PROCEDURE FOR THE PREPARATION OF HIV REVERS TRANSCIPTASE INHIBITORS. - Google Patents

PROCEDURE FOR THE PREPARATION OF HIV REVERS TRANSCIPTASE INHIBITORS.

Info

Publication number
NO912341L
NO912341L NO91912341A NO912341A NO912341L NO 912341 L NO912341 L NO 912341L NO 91912341 A NO91912341 A NO 91912341A NO 912341 A NO912341 A NO 912341A NO 912341 L NO912341 L NO 912341L
Authority
NO
Norway
Prior art keywords
preparation
revers
hiv
procedure
alkyl
Prior art date
Application number
NO91912341A
Other languages
Norwegian (no)
Other versions
NO912341D0 (en
Inventor
Mark E Goldman
Jr Jacob M Hoffmann
George D Hartman
Martha L Quesada-Kieczyk
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO912341D0 publication Critical patent/NO912341D0/en
Publication of NO912341L publication Critical patent/NO912341L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nye forbindelser av formlene. hvori A erellerB er C.-alkoksy; X er NH, 0, S eller CH; Z er 0 eller S; n er 1-4; Rj er (i) C-alkyl, eventuelt substituert med én eller to av C^-alkoksy, halogen, C^-alkylamino, C.-dialkylamino eller C-alkyltio; (ii) C.-lkyltio; (iii) C.-alkoksy; eller (iv) halogen; Rer (i) H; (ii) C-alkyl, eventuelt substituert med én eller to av metoksy, metylamino, dimetylamino eller metyl-tio; Rer H eller C.g-alkyl; Ph er ftaloyl av strukturen. hvori m er 0-2, forutsatt at når A er NH-CH-Ph, kan både Rj og Rikke være C.-alkyl, utviser terapeutisk akti-vitet. Fremstilling av forbindelsene er beskrevet.New compounds of the formulas. wherein A is or B is C 1-4 alkoxy; X is NH, O, S or CH; Z is 0 or S; n is 1-4; R 1 is (i) C 1-4 alkyl, optionally substituted with one or two of C 1-4 alkoxy, halogen, C 1-4 alkylamino, C 1-6 dialkylamino or C 1-4 alkylthio; (ii) C 1-4 alkylthio; (iii) C 1-4 alkoxy; or (iv) halogen; Rer (i) H; (ii) C-alkyl, optionally substituted with one or two of methoxy, methylamino, dimethylamino or methylthio; R 1 is H or C 1-6 alkyl; Ph is phthaloyl of the structure. wherein m is 0-2, provided that when A is NH-CH-Ph, both R j and Rikke may be C 1-6 alkyl, exhibiting therapeutic activity. Preparation of the compounds is described.

NO91912341A 1990-06-18 1991-06-17 PROCEDURE FOR THE PREPARATION OF HIV REVERS TRANSCIPTASE INHIBITORS. NO912341L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53976090A 1990-06-18 1990-06-18

Publications (2)

Publication Number Publication Date
NO912341D0 NO912341D0 (en) 1991-06-17
NO912341L true NO912341L (en) 1991-12-19

Family

ID=24152525

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91912341A NO912341L (en) 1990-06-18 1991-06-17 PROCEDURE FOR THE PREPARATION OF HIV REVERS TRANSCIPTASE INHIBITORS.

Country Status (3)

Country Link
KR (1) KR920000747A (en)
NO (1) NO912341L (en)
ZA (1) ZA914653B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030010452A (en) * 2001-11-30 2003-02-05 이종선 Automatic Modular Cleaner System

Also Published As

Publication number Publication date
ZA914653B (en) 1992-03-25
KR920000747A (en) 1992-01-29
NO912341D0 (en) 1991-06-17

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