DE69826034D1 - 1,2-dihydro-2-oxoquinoline-DERIVATIVES - Google Patents

1,2-dihydro-2-oxoquinoline-DERIVATIVES

Info

Publication number
DE69826034D1
DE69826034D1 DE69826034T DE69826034T DE69826034D1 DE 69826034 D1 DE69826034 D1 DE 69826034D1 DE 69826034 T DE69826034 T DE 69826034T DE 69826034 T DE69826034 T DE 69826034T DE 69826034 D1 DE69826034 D1 DE 69826034D1
Authority
DE
Germany
Prior art keywords
group
different
same
hydrogen atom
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69826034T
Other languages
German (de)
Other versions
DE69826034T2 (en
Inventor
Atsuro Nakazato
Taketoshi Okubo
Toshihito Kumagai
Shigeyuki Chaki
Kazuyuki Tomisawa
Masashi Nagamine
Makoto Gotoh
Masanori Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69826034D1 publication Critical patent/DE69826034D1/en
Publication of DE69826034T2 publication Critical patent/DE69826034T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A 1,2-dihydro-2-oxoquinoline derivative represented by the formula: <CHEM> wherein Ar is a pyridyl group or a group represented by the formula: <CHEM> (wherein X<3> and X<4> are the same or different, and are each a hydrogen atom, a halogen atom, a C1-5 alkyl group, a C1-5 alkoxy group, a hydroxyl group or a trifluoromethyl group), Y is a nitrogen atom, CH or C(OH), R<1> and R<2> are the same or different, and are each a hydrogen atom, a C1-10 alkyl group, a C3-15 alkoxyalkyl group or a C3-15 alkylaminoalkyl group, or R<1> and R<2> taken together with the nitrogen atom to which they are attached form a cyclic amino group, X<1> and X<2> are the same or different, and are each a hydrogen atom, a C1-5 alkyl group, a C1-5 alkoxy group or a halogen atom, or X<1> and X<2> taken together form an alkylenedioxy group, and n is an integer of 1 to 3; or a pharmaceutically acceptable salt thereof.
DE69826034T 1997-12-03 1998-12-03 1,2-dihydro-2-oxoquinoline-DERIVATIVES Expired - Fee Related DE69826034T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33253997 1997-12-03
JP33253997 1997-12-03
PCT/JP1998/005451 WO1999028299A1 (en) 1997-12-03 1998-12-03 1,2-dihydro-2-oxoquinoline derivatives

Publications (2)

Publication Number Publication Date
DE69826034D1 true DE69826034D1 (en) 2004-10-07
DE69826034T2 DE69826034T2 (en) 2005-09-08

Family

ID=18256057

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69826034T Expired - Fee Related DE69826034T2 (en) 1997-12-03 1998-12-03 1,2-dihydro-2-oxoquinoline-DERIVATIVES

Country Status (11)

Country Link
US (2) US6329525B1 (en)
EP (1) EP1048655B1 (en)
KR (1) KR20010032667A (en)
CN (1) CN1118456C (en)
AT (1) ATE275133T1 (en)
AU (1) AU736232B2 (en)
CA (1) CA2313055A1 (en)
DE (1) DE69826034T2 (en)
ES (1) ES2227893T3 (en)
HK (1) HK1034074A1 (en)
WO (1) WO1999028299A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000256323A (en) 1999-01-08 2000-09-19 Japan Tobacco Inc 2-oxoquinoline compound and its medicinal use
WO2004103974A1 (en) * 2003-05-23 2004-12-02 Japan Tobacco Inc. Substituted 2-oxoquinoline compound and medicinal use thereof
SE0302323D0 (en) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
WO2005021547A2 (en) * 2003-08-28 2005-03-10 Pharmaxis Pty Ltd. Heterocyclic cannabinoid cb2 receptor antagonists
WO2008113006A1 (en) * 2007-03-14 2008-09-18 Xenon Pharmaceuticals Inc. Methods of using quinolinone compounds in treating sodium channel-mediated diseases or conditions
NZ582426A (en) 2007-08-01 2011-04-29 Kumiai Chemical Industry Co Oxopyrazine derivative and herbicide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2509728A1 (en) 1981-07-17 1983-01-21 Roussel Uclaf NOVEL QUINOLINE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
JPS63146872A (en) * 1986-07-08 1988-06-18 Yoshitomi Pharmaceut Ind Ltd Pyrimidinylpiperazine compound
JPH02152966A (en) 1988-12-05 1990-06-12 Otsuka Pharmaceut Co Ltd 4-hydroxycarbostyril derivative
JP3122671B2 (en) 1990-05-23 2001-01-09 協和醗酵工業株式会社 Heterocyclic compounds
GB9108547D0 (en) * 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
US5206382A (en) 1991-06-27 1993-04-27 Fidia Georgetown Institute For The Neurosciences Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders
FR2717175B1 (en) * 1994-03-11 1996-06-14 Adir New alkylaminoindane compounds, processes for their preparation and pharmaceutical compositions containing them.
JP3888393B2 (en) * 1995-03-10 2007-02-28 大正製薬株式会社 Quinolone derivatives
EP1070054A1 (en) * 1998-04-08 2001-01-24 Takeda Chemical Industries, Ltd. Amine compounds, their production and their use as somatostatin receptor antagonists or agonists

Also Published As

Publication number Publication date
WO1999028299A1 (en) 1999-06-10
US20020049323A1 (en) 2002-04-25
EP1048655A4 (en) 2001-04-18
US6380384B1 (en) 2002-04-30
CN1280569A (en) 2001-01-17
ES2227893T3 (en) 2005-04-01
EP1048655B1 (en) 2004-09-01
CN1118456C (en) 2003-08-20
DE69826034T2 (en) 2005-09-08
KR20010032667A (en) 2001-04-25
CA2313055A1 (en) 1999-06-10
AU736232B2 (en) 2001-07-26
AU1350999A (en) 1999-06-16
ATE275133T1 (en) 2004-09-15
EP1048655A1 (en) 2000-11-02
HK1034074A1 (en) 2001-10-12
US6329525B1 (en) 2001-12-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee