MX9702152A - Clonacion de una aminopeptidasa de membrana, dependiente de la insulina, a partir de vesiculas de glut-4. - Google Patents
Clonacion de una aminopeptidasa de membrana, dependiente de la insulina, a partir de vesiculas de glut-4.Info
- Publication number
- MX9702152A MX9702152A MX9702152A MX9702152A MX9702152A MX 9702152 A MX9702152 A MX 9702152A MX 9702152 A MX9702152 A MX 9702152A MX 9702152 A MX9702152 A MX 9702152A MX 9702152 A MX9702152 A MX 9702152A
- Authority
- MX
- Mexico
- Prior art keywords
- gln
- ala
- seq
- insulin
- thr
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8103—Exopeptidase (E.C. 3.4.11-19) inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Una peptidasa que divide una insulina se ha purificado a partir de vesículas que contiene GLUT-4 y se ha clonado. La peptidasa tiene una masa medida de aproximadamente 165 kD, pero es de 110 kD en su estado desglicosilado. Se ha predecido una masa de 117.239 Daltons basado en la secuencia de aminoácidos predicha del ADNc de la figura (SEC ID Nos: 15 y 16). Incluye péptidos que tiene las secuencias de aminoácidos Phe-Ala-Ala-Thr-Gln-Phe-Glu-Pro-Leu-Ala-Ala (sec id NO: 1) y Ile-Leu-Gln-Asn-Gln-Ile-Gln-Gln-Gln-Thr-Arg-Thr-As p-Glu-Gly-Xaa-Pro-Xaa-Met (SEC ID NO: 2) y se enlaza con los anticuerpos producidos contra el péptido identificado como (SEC ID NO: 1). También se reclaman los moduladores y un método para el tratamiento de síndrome de la resistencia a la insulina, que incluye la diabetes, mediante la administracion de tal modulador.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30923294A | 1994-09-20 | 1994-09-20 | |
US309232 | 1994-09-20 | ||
PCT/US1995/011902 WO1996009317A1 (en) | 1994-09-20 | 1995-09-19 | Cloning of an insulin-dependent membrane aminopeptidase from glut-4 vesicles |
Publications (2)
Publication Number | Publication Date |
---|---|
MXPA97002152A MXPA97002152A (es) | 1998-04-01 |
MX9702152A true MX9702152A (es) | 1998-04-30 |
Family
ID=23197290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9702152A MX9702152A (es) | 1994-09-20 | 1995-09-19 | Clonacion de una aminopeptidasa de membrana, dependiente de la insulina, a partir de vesiculas de glut-4. |
Country Status (8)
Country | Link |
---|---|
US (2) | US5968764A (es) |
EP (1) | EP0782581A4 (es) |
JP (1) | JPH10506015A (es) |
AU (1) | AU709169B2 (es) |
CA (1) | CA2200354A1 (es) |
MX (1) | MX9702152A (es) |
NZ (1) | NZ294397A (es) |
WO (1) | WO1996009317A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1107987A2 (en) * | 1998-08-26 | 2001-06-20 | Trustees Of Boston University | Novel irap-bp polypeptide and nucleic acid molecules and uses therefor |
US6235481B1 (en) | 1998-10-21 | 2001-05-22 | Arch Development Corporation & Board Of Regents | Polynucleotides encoding calpain 10 |
US6362324B1 (en) * | 1999-06-30 | 2002-03-26 | Millennium Pharmaceuticals, Inc. | 17867 a novel human aminopeptidase |
US6639918B1 (en) * | 2000-01-18 | 2003-10-28 | Apple Computer, Inc. | Method and apparatus for border node behavior on a full-duplex bus |
JP2003522530A (ja) * | 2000-02-11 | 2003-07-29 | レキシコン・ジェネティクス・インコーポレーテッド | 新規ヒトプロテアーゼ及び該プロテアーゼをコードするポリヌクレオチド |
US7135303B2 (en) * | 2000-02-28 | 2006-11-14 | The United States Of America As Represented By The Department Of Health And Human Services | Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding |
GB0014838D0 (en) * | 2000-06-16 | 2000-08-09 | Univ Bristol | An assay |
AU2001278777A1 (en) * | 2000-08-21 | 2002-03-04 | Takeda Chemical Industries Ltd. | Irap-binding protein |
AU2002259161A1 (en) * | 2001-05-08 | 2002-11-18 | Adipogenix, Inc. | Methods and reagents for identifying insulin response modulators and therapeutic uses therefor |
US7033771B2 (en) * | 2001-05-08 | 2006-04-25 | Takeda Pharmaceutical Company Limited | Use of insulin response modulators in the treatment of diabetes and insulin resistance |
WO2003011304A1 (en) * | 2001-08-02 | 2003-02-13 | Howard Florey Institute Of Experimental Physiology And Medicine | Modulation of insulin-regulated aminopeptidase (irap)/angiotensin iv (at4) receptor activity |
AU2002317634B8 (en) * | 2001-08-02 | 2008-09-25 | Howard Florey Institute Of Experimental Physiology And Medicine | Modulation of insulin-regulated aminopeptidase (IRAP)/Angiotensin IV (AT4) receptor activity |
US8460243B2 (en) | 2003-06-10 | 2013-06-11 | Abbott Diabetes Care Inc. | Glucose measuring module and insulin pump combination |
US7722536B2 (en) | 2003-07-15 | 2010-05-25 | Abbott Diabetes Care Inc. | Glucose measuring device integrated into a holster for a personal area network device |
WO2005117950A2 (en) * | 2004-05-28 | 2005-12-15 | The Regents Of The University Of California | Regulation of glucose and insulin levels by gnt-4 glycosyltransferase activity |
CA2858901C (en) | 2004-06-04 | 2024-01-16 | Carolyn Anderson | Diabetes care host-client architecture and data management system |
US10136845B2 (en) | 2011-02-28 | 2018-11-27 | Abbott Diabetes Care Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
WO2019213024A1 (en) * | 2018-04-30 | 2019-11-07 | Integral Molecular, Inc. | Glucose transporter 4 antibodies, methods of making the same, and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225354A (en) * | 1986-08-22 | 1993-07-06 | Molecular Diagnostics, Inc. | Monoclonal antibodies specific for human glycoalbumin |
JPH05308965A (ja) * | 1991-04-08 | 1993-11-22 | Suntory Ltd | 新規ロイシンアミノペプチダーゼ |
EP0721508B1 (en) * | 1993-09-27 | 2009-01-07 | University Of Massachusetts Medical Center | Receptor-activated reporter systems |
-
1995
- 1995-05-04 US US08/437,116 patent/US5968764A/en not_active Expired - Fee Related
- 1995-09-19 MX MX9702152A patent/MX9702152A/es unknown
- 1995-09-19 US US08/530,792 patent/US5972680A/en not_active Expired - Fee Related
- 1995-09-19 NZ NZ294397A patent/NZ294397A/xx unknown
- 1995-09-19 AU AU37191/95A patent/AU709169B2/en not_active Ceased
- 1995-09-19 CA CA002200354A patent/CA2200354A1/en not_active Abandoned
- 1995-09-19 EP EP95935008A patent/EP0782581A4/en not_active Withdrawn
- 1995-09-19 WO PCT/US1995/011902 patent/WO1996009317A1/en not_active Application Discontinuation
- 1995-09-19 JP JP8511031A patent/JPH10506015A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2200354A1 (en) | 1996-03-28 |
WO1996009317A1 (en) | 1996-03-28 |
US5972680A (en) | 1999-10-26 |
JPH10506015A (ja) | 1998-06-16 |
EP0782581A4 (en) | 2000-05-31 |
NZ294397A (en) | 2000-04-28 |
AU709169B2 (en) | 1999-08-26 |
AU3719195A (en) | 1996-04-09 |
US5968764A (en) | 1999-10-19 |
EP0782581A1 (en) | 1997-07-09 |
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