MX9606566A - Derivados 3-amina-2-0xo-1-piperidin aceticos como inhibidores de enzima. - Google Patents

Derivados 3-amina-2-0xo-1-piperidin aceticos como inhibidores de enzima.

Info

Publication number
MX9606566A
MX9606566A MX9606566A MX9606566A MX9606566A MX 9606566 A MX9606566 A MX 9606566A MX 9606566 A MX9606566 A MX 9606566A MX 9606566 A MX9606566 A MX 9606566A MX 9606566 A MX9606566 A MX 9606566A
Authority
MX
Mexico
Prior art keywords
piperidineacetic
oxo
derivatives
amino
enzyme inhibitors
Prior art date
Application number
MX9606566A
Other languages
English (en)
Inventor
Joseph Edward Semple
Robert J Ardecky
Ruth F Nutt
William Charles Ripka
David C Rowley
Marguerita S L Lim-Wilby
Terrence K Brunck
Original Assignee
Corvas Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corvas Int Inc filed Critical Corvas Int Inc
Priority claimed from PCT/US1995/007661 external-priority patent/WO1995035311A1/en
Publication of MX9606566A publication Critical patent/MX9606566A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion describe aldehidos peptidicos que son inhibidores potentes y específicos de trombina, sus sales farmacéuticamente aceptables, composiciones farmacéuticamente, aceptables de los mismos, y métodos de uso de los mismos como agente terapéuticos para estados patologicos en mamíferos caracterizados por trombosis anormal.
MX9606566A 1994-06-17 1995-06-19 Derivados 3-amina-2-0xo-1-piperidin aceticos como inhibidores de enzima. MX9606566A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26137894A 1994-06-17 1994-06-17
US35683194A 1994-12-13 1994-12-13
US48700795A 1995-06-07 1995-06-07
PCT/US1995/007661 WO1995035311A1 (en) 1994-06-17 1995-06-19 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors

Publications (1)

Publication Number Publication Date
MX9606566A true MX9606566A (es) 1997-07-31

Family

ID=27401400

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9606566A MX9606566A (es) 1994-06-17 1995-06-19 Derivados 3-amina-2-0xo-1-piperidin aceticos como inhibidores de enzima.

Country Status (8)

Country Link
EP (1) EP0802923A1 (es)
CN (1) CN1151166A (es)
AU (1) AU700808B2 (es)
BR (1) BR9508048A (es)
CA (1) CA2192210A1 (es)
MX (1) MX9606566A (es)
NO (1) NO965353L (es)
NZ (1) NZ288940A (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192875A (en) * 1979-02-02 1980-03-11 Merck & Co., Inc. Cyclic hexapeptide

Also Published As

Publication number Publication date
NO965353L (no) 1997-02-17
AU700808B2 (en) 1999-01-14
EP0802923A1 (en) 1997-10-29
CA2192210A1 (en) 1995-12-28
NO965353D0 (no) 1996-12-13
BR9508048A (pt) 1997-11-18
AU2863095A (en) 1996-01-15
CN1151166A (zh) 1997-06-04
NZ288940A (en) 1999-01-28

Similar Documents

Publication Publication Date Title
AU4424896A (en) Aromatic heterocyclic derivatives as enzyme inhibitors
WO1997046207A3 (en) Aromatic heterocyclic derivatives as enzyme inhibitors
MX9704684A (es) Derivados de glicina n-sustituidos, como inhibidores del factor xa.
AU2905495A (en) 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
DE60021254D1 (en) N-cyanomethylamide als protease inhibitoren
EP0675899A4 (en) NEW INHIBITORS FROM FACTOR Xa.
DE69427127D1 (de) Substituierte tetra- und pentapeptid hemmstoffe der farnesyl protein transferase
BG104779A (en) Inhibitors of phospholipase enzymes
PT915898E (pt) Forma i cristalina de claritromicina
MY129998A (en) Saccharin derivative proteolytic enzyme inhibitors
CA2319554A1 (en) Quinoxalinones as serine protease inhibitors such as factor xa and thrombin
BR9811099A (pt) Inibidores de urocinase
MY110104A (en) Saccharin derivative proteolytic enzyme inhibitors
IT1276162B1 (it) Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceutiche
EP1019047A4 (en) ANTITHROMBOTIC AGENTS
MX9606566A (es) Derivados 3-amina-2-0xo-1-piperidin aceticos como inhibidores de enzima.
UA66932C2 (en) Complex of eletriptan and sulphobutylether-beta-cyclodextrin, pharmaceutical composition, method for their manufacture and method for treating migraine
ATE179182T1 (de) Arginin ahnliche derivate als enzym-inhibitoren
YU28999A (sh) Postupak za kristalisanje derivata tetrahidropiridina i dobijeni kristalni oblici
WO2001079195A3 (en) Pyridine and pyrazine derivatives as thrombin inhibitors
EP1452522A3 (en) Novel compounds and compositions as protease inhibitors
EP0980366A4 (en) ANTITHROMOSIS
MX9703208A (es) Tetra-y pentapeptidos substituidos inhibidores de proteina; farnesil transferasa.