MX9604761A - Metodo y aparato para homogeneizar formulaciones de aerosol. - Google Patents
Metodo y aparato para homogeneizar formulaciones de aerosol.Info
- Publication number
- MX9604761A MX9604761A MX9604761A MX9604761A MX9604761A MX 9604761 A MX9604761 A MX 9604761A MX 9604761 A MX9604761 A MX 9604761A MX 9604761 A MX9604761 A MX 9604761A MX 9604761 A MX9604761 A MX 9604761A
- Authority
- MX
- Mexico
- Prior art keywords
- homogenizing
- homogenizer
- stream
- aerosol formulations
- micronizing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
- B01F25/23—Mixing by intersecting jets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
- B01F25/51—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle in which the mixture is circulated through a set of tubes, e.g. with gradual introduction of a component into the circulating flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
- B01F25/52—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle with a rotary stirrer in the recirculation tube
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/82—Combinations of dissimilar mixers
- B01F33/821—Combinations of dissimilar mixers with consecutive receptacles
- B01F33/8212—Combinations of dissimilar mixers with consecutive receptacles with moving and non-moving stirring devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/113—Propeller-shaped stirrers for producing an axial flow, e.g. shaped like a ship or aircraft propeller
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Colloid Chemistry (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
Un método y aparato para homogeneizar y micronizar formulaciones de aerosol. El método incluye las etapas de homogeneizar y micronizar una formulacion de aerosol a temperatura ambiente en un aparato cerrado, en el que todo el aparato se mantiene a presion elevada. El aparato incluye un bucle cerrado que contiene un recipiente de reaccion, un homogeneizador y un conducto de fluido que interconecta el recipiente de reaccion y el homogeneizador. El homogeneizador incluye una cámara de interaccion y una bomba de intensificador. La cámara de interaccion incluye un dispositivo divisor de la corriente para separar una corriente de componentes de la formulacion de aerosol en dos corrientes y una cámara de impactacion para recombinar la corriente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US546395P | 1995-10-13 | 1995-10-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9604761A true MX9604761A (es) | 1997-04-30 |
Family
ID=21716000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9604761A MX9604761A (es) | 1995-10-13 | 1996-10-11 | Metodo y aparato para homogeneizar formulaciones de aerosol. |
Country Status (5)
Country | Link |
---|---|
US (1) | US6135628A (es) |
EP (1) | EP0768114A3 (es) |
JP (1) | JPH09122466A (es) |
CA (1) | CA2187698A1 (es) |
MX (1) | MX9604761A (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7654728B2 (en) | 1997-10-24 | 2010-02-02 | Revalesio Corporation | System and method for therapeutic application of dissolved oxygen |
US6702949B2 (en) | 1997-10-24 | 2004-03-09 | Microdiffusion, Inc. | Diffuser/emulsifier for aquaculture applications |
US7128278B2 (en) | 1997-10-24 | 2006-10-31 | Microdiffusion, Inc. | System and method for irritating with aerated water |
US6386751B1 (en) | 1997-10-24 | 2002-05-14 | Diffusion Dynamics, Inc. | Diffuser/emulsifier |
US5927852A (en) * | 1997-12-01 | 1999-07-27 | Minnesota Mining And Manfacturing Company | Process for production of heat sensitive dispersions or emulsions |
IT1303692B1 (it) * | 1998-11-03 | 2001-02-23 | Chiesi Farma Spa | Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione. |
JP5392880B2 (ja) * | 2000-05-22 | 2014-01-22 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 加圧式定量吸入器のための安定な製薬学的溶液製剤 |
US20040081627A1 (en) * | 2000-10-09 | 2004-04-29 | Jinks Phillip A | Medicinal aerosol formulations |
DE10059430A1 (de) * | 2000-11-30 | 2002-06-06 | Cognis Deutschland Gmbh | Feinteilige Emulsionen |
JP4014896B2 (ja) * | 2001-05-25 | 2007-11-28 | 株式会社トクヤマ | 水処理用凝集剤の製造方法 |
US20030091513A1 (en) * | 2001-10-03 | 2003-05-15 | Mohsen Nahed M. | Method to generate water soluble or nonwater soluble in nanoparticulates directly in suspension or dispersion media |
EP1470855B1 (en) * | 2002-01-09 | 2008-06-18 | BeRyu Co., Ltd. | Emulsifying/dispersing system |
JPWO2005013938A1 (ja) * | 2003-08-06 | 2006-09-28 | エーザイ株式会社 | 薬物超微粒子の製造法及び製造装置 |
DE10360766A1 (de) * | 2003-12-23 | 2005-07-28 | Degussa Ag | Verfahren und Vorrichtung zur Herstellung von Dispersionen |
GB0406515D0 (en) * | 2004-03-23 | 2004-04-28 | Novartis Ag | Organic compounds |
WO2005089718A2 (en) * | 2004-03-23 | 2005-09-29 | Novartis Ag | Pharmaceutical compositions |
US20070183999A1 (en) * | 2006-01-27 | 2007-08-09 | L'oreal | Method of preparing a cosmetic composition, and an apparatus for implementing such a method |
US8445546B2 (en) | 2006-10-25 | 2013-05-21 | Revalesio Corporation | Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures |
WO2008052145A2 (en) | 2006-10-25 | 2008-05-02 | Revalesio Corporation | Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution |
US8609148B2 (en) | 2006-10-25 | 2013-12-17 | Revalesio Corporation | Methods of therapeutic treatment of eyes |
WO2008115290A2 (en) | 2006-10-25 | 2008-09-25 | Revalesio Corporation | Methods of wound care and treatment |
US8784897B2 (en) | 2006-10-25 | 2014-07-22 | Revalesio Corporation | Methods of therapeutic treatment of eyes |
US8784898B2 (en) | 2006-10-25 | 2014-07-22 | Revalesio Corporation | Methods of wound care and treatment |
EP3170401B1 (en) | 2006-10-25 | 2019-06-05 | Revalesio Corporation | Ionic aqueous fluid composition containing oxygen microbubbles |
US9745567B2 (en) | 2008-04-28 | 2017-08-29 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
US10125359B2 (en) | 2007-10-25 | 2018-11-13 | Revalesio Corporation | Compositions and methods for treating inflammation |
US9523090B2 (en) | 2007-10-25 | 2016-12-20 | Revalesio Corporation | Compositions and methods for treating inflammation |
BRPI0911757A2 (pt) | 2008-05-01 | 2013-09-17 | Revalesio Corp | composiÇÕes e mÉtodos para tratar distérbios digestivos. |
US8853284B2 (en) | 2008-06-02 | 2014-10-07 | Honeywell International Inc. | Wax dispersion formulations, method of producing same, and uses |
US8815292B2 (en) | 2009-04-27 | 2014-08-26 | Revalesio Corporation | Compositions and methods for treating insulin resistance and diabetes mellitus |
MX2012012971A (es) | 2010-05-07 | 2013-02-07 | Revalesio Corp | Composiciones y metodos para mejorar el rendimiento fisiologico y el tiempo de recuperacion. |
BR112013003110A2 (pt) | 2010-08-12 | 2016-06-28 | Revalesio Corp | composições e métodos para tratamento de taupatia |
CN102488619B (zh) * | 2011-12-05 | 2014-08-06 | 上海交通大学 | 连续生产艾塞那肽微球的装置及控制微球释放速度的方法 |
WO2014139168A1 (en) * | 2013-03-15 | 2014-09-18 | Tuo Jin | Preparation process of polymeric microspheres |
US9682494B2 (en) * | 2014-03-20 | 2017-06-20 | Amix Systems Ltd. | Colloidal mixing method for slurries |
JP6388501B2 (ja) * | 2014-06-27 | 2018-09-12 | 澁谷工業株式会社 | スラリー分散システム |
CN104162390B (zh) * | 2014-07-03 | 2016-01-13 | 苏州宏瑞净化科技有限公司 | 一种粉尘气溶胶发生装置 |
CN105413556B (zh) * | 2014-09-15 | 2018-04-24 | 广东雪莱特光电科技股份有限公司 | 一种氧化铝分散装置 |
EP3430264B1 (en) * | 2016-03-14 | 2021-11-24 | Microfluidics International Corporation | High-pressure fluid processing device configured for batch processing |
JP7245163B2 (ja) | 2017-01-17 | 2023-03-23 | マイクロフルーイディクス インターナショナル コーポレイション | 高圧デュアルチェックバルブを用いた装置及び方法 |
CN108854633A (zh) * | 2018-06-29 | 2018-11-23 | 上海励途机械设备工程有限公司 | 增压泵式超高压微射流均质机 |
CN109091387B (zh) * | 2018-07-14 | 2020-11-03 | 羊凌峰 | 用于生物制药辅助加工的装置 |
CN108970440A (zh) * | 2018-08-01 | 2018-12-11 | 芜湖市三山龙城新材料有限公司 | 适用于涂料生产的循环式混合设备 |
CN109224909A (zh) * | 2018-10-23 | 2019-01-18 | 郑州莱兹电子科技有限公司 | 一种便于移动的电子产品生产用物料分散设备 |
CN111871295B (zh) * | 2020-07-29 | 2022-08-23 | 河北养元智汇饮品股份有限公司 | 一种均质机加压系统及其加压方法 |
CN113576913A (zh) * | 2021-08-28 | 2021-11-02 | 江西中医药大学 | 一种中药连续制造方法及其系统装备 |
TWI805258B (zh) * | 2022-03-07 | 2023-06-11 | 財團法人食品工業發展研究所 | 顆粒定量混合設備 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE369967A (es) * | ||||
NL128441C (es) * | 1960-03-10 | 1900-01-01 | ||
US4405489A (en) * | 1981-01-15 | 1983-09-20 | Carter-Wallace, Inc. | Production of a post-foaming gel and system therefor |
US4908154A (en) * | 1981-04-17 | 1990-03-13 | Biotechnology Development Corporation | Method of forming a microemulsion |
US4533254A (en) * | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
DE3810462A1 (de) * | 1988-03-26 | 1989-10-05 | Dechema | Verfahren zum aufschluss von zellen in einer zellsuspension und vorrichtung zur durchfuehrung des verfahrens |
US4971788A (en) * | 1989-01-27 | 1990-11-20 | Medicontrol Corporation | Oral cavity and dental microemulsion products |
US5270305A (en) * | 1989-09-08 | 1993-12-14 | Glaxo Group Limited | Medicaments |
DE4003270A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
DE69522232T2 (de) * | 1994-11-14 | 2002-06-13 | Minnesota Mining And Mfg. Co., Saint Paul | Verfahren und vorrichtung zur herstellung einer dispersion von hartstoffteilchen in einem lösungsmittel |
UY24147A1 (es) * | 1995-01-20 | 1996-02-02 | Gruenenthal Chemie | Procedimiento y dispositivo para preparar composiciones dispersables por aspersion de aerosoles |
US5603918A (en) * | 1995-06-09 | 1997-02-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aerosol composition of a salt of ipratropium and a salt of albuterol |
-
1996
- 1996-09-30 US US08/723,520 patent/US6135628A/en not_active Expired - Lifetime
- 1996-10-11 JP JP8270246A patent/JPH09122466A/ja active Pending
- 1996-10-11 CA CA002187698A patent/CA2187698A1/en not_active Abandoned
- 1996-10-11 EP EP96116310A patent/EP0768114A3/en not_active Withdrawn
- 1996-10-11 MX MX9604761A patent/MX9604761A/es not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH09122466A (ja) | 1997-05-13 |
EP0768114A3 (en) | 1997-07-30 |
CA2187698A1 (en) | 1997-04-14 |
US6135628A (en) | 2000-10-24 |
EP0768114A2 (en) | 1997-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |