MX9306392A - Composicion y metodo para evitar la sobredosis de acetaminofen - Google Patents
Composicion y metodo para evitar la sobredosis de acetaminofenInfo
- Publication number
- MX9306392A MX9306392A MX9306392A MX9306392A MX9306392A MX 9306392 A MX9306392 A MX 9306392A MX 9306392 A MX9306392 A MX 9306392A MX 9306392 A MX9306392 A MX 9306392A MX 9306392 A MX9306392 A MX 9306392A
- Authority
- MX
- Mexico
- Prior art keywords
- acetaminophen
- acetaminofen
- composition
- diallyl
- daso2
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se describe un método para prevenir la hepatotoxicidad inducida por acetaminofén o acetaminoféno (ADAP) utilizando sulfuro de dialilo (DAS) y sulfona de dialilo (DASO2). Se preparan DAS y DASO2 como una modalidad preferida, se agrega sulfona de dialilo a una forma de dosificción de acetaminofén en una cantidad efectiva para evitar el metabolismo de tal dosis unitaria de acetaminofén en sus metabolitos anteriores incluyen de manera adicional una cantidad efectiva de N-acetilcisteína para destoxificar metabolitos hepatotóxicos de acetaminofén.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/962,529 US5474757A (en) | 1992-10-16 | 1992-10-16 | Prevention of acetaminophen overdose toxicity with organosulfur compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9306392A true MX9306392A (es) | 1994-05-31 |
Family
ID=25506019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9306392A MX9306392A (es) | 1992-10-16 | 1993-10-14 | Composicion y metodo para evitar la sobredosis de acetaminofen |
Country Status (4)
Country | Link |
---|---|
US (1) | US5474757A (es) |
AU (1) | AU5442094A (es) |
MX (1) | MX9306392A (es) |
WO (1) | WO1994008628A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9305058D0 (en) * | 1993-03-12 | 1993-04-28 | Penn Pharm Ltd | Pharmaceutical compositions |
KR100405116B1 (ko) * | 1995-02-28 | 2004-02-05 | 아벤티스 파마슈티칼스 인크. | 피페리디노알칸올화합물에대한약제학적조성물 |
FR2744917B1 (fr) * | 1996-02-16 | 1998-04-10 | Kouchner Gerard | Composition therapeutique a base d'acetaminophene |
FR2751875B1 (fr) * | 1996-08-05 | 1998-12-24 | Scr Newpharm | Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation |
US6048540A (en) * | 1997-01-29 | 2000-04-11 | Chong Kun Dang Corp. | Acetamenophen composition with reduced liver toxicity |
TR200000517T2 (tr) * | 1997-08-26 | 2000-08-21 | Hoechst Marion Roussel, Inc. | Piperidinoalkanol-Konjesyon azaltıcıdan oluşan kombinasyona yönelik farmasötik kompozisyon. |
US20070141181A1 (en) | 1998-02-13 | 2007-06-21 | Nutramax Laboratories, Inc. | Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals |
US6797289B2 (en) | 1998-02-13 | 2004-09-28 | Nutramax Laboratories, Inc. | Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals |
WO1999043336A1 (en) | 1998-02-27 | 1999-09-02 | Nutramax Laboratories, Inc. | L-ergothioneine, milk thistle, and s-adenosylmethionine for the prevention, treatment and repair of liver damage |
US20010000472A1 (en) * | 1998-02-27 | 2001-04-26 | Nutramax Laboratories, Inc. | L-ergothioneine, milk thistle, and s-adenosylmethionine for the prevention, treatment and repair of liver damage |
US6245336B1 (en) | 1999-03-11 | 2001-06-12 | Dry Creek Nutrition, Inc. | Prevention and treatment of acetaminophen toxicity with grape seed proanthocyanidin extract |
US6281222B1 (en) | 1999-08-19 | 2001-08-28 | Inotek Corporation | Compositions and method for treatment of acetaminophen intoxication |
US6759062B2 (en) | 2000-02-23 | 2004-07-06 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
US6787164B2 (en) | 2000-02-23 | 2004-09-07 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
US6793942B2 (en) | 2000-02-23 | 2004-09-21 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
US6841544B2 (en) * | 2000-02-23 | 2005-01-11 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
KR100408107B1 (ko) * | 2000-10-27 | 2003-12-01 | 정세영 | 류코시아니딘을 함유하는 간 보호용 약학 조성물 |
US6566401B2 (en) * | 2001-03-30 | 2003-05-20 | The Board Of Trustees Of The Leland Stanford Junior University | N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity |
US20050220862A1 (en) | 2004-03-31 | 2005-10-06 | Bernstein Joel E | Compositions with reduced hepatotoxicity |
TWI273911B (en) * | 2005-01-18 | 2007-02-21 | Univ Nat Chiao Tung | Prevention and amelioration of acetaminophen toxicity with tea melanin |
AU2011202871B2 (en) * | 2005-08-24 | 2014-06-12 | Cumberland Pharmaceuticals Inc. | Acetylcysteine composition and uses therefor |
US8148356B2 (en) | 2005-08-24 | 2012-04-03 | Cumberland Pharmaceuticals, Inc. | Acetylcysteine composition and uses therefor |
WO2007044700A2 (en) * | 2005-10-07 | 2007-04-19 | Board Of Trustees Of Southern Illinois University | Protectant combinations for reducing toxicities |
US20080188439A1 (en) * | 2006-10-26 | 2008-08-07 | Salhanick Steven D | Directed metabolism of compounds by glucuronidation and sulfonation donors to decrease toxicity |
US20080139654A1 (en) * | 2006-12-09 | 2008-06-12 | Eric Mott Soderling | Acetaminophen compositions having minimized side effects including reduced hepatotoxicity |
ITMI20080187A1 (it) * | 2008-02-07 | 2009-08-08 | Velleja Res Srl | Formulazioni di amminoacidi per la prevenzione del danno epatico da paracetamolo |
BRPI0912820A2 (pt) * | 2008-05-20 | 2015-10-13 | Neurogesx Inc | pró-fármacos de relação hepatoprotetora de acetaminofeno |
CN105687177A (zh) | 2009-07-15 | 2016-06-22 | 小利兰·斯坦福大学托管委员会 | N-乙酰半胱氨酸组合物以及改善对乙酰氨基酚的治疗效能的方法 |
KR20240051283A (ko) | 2013-12-24 | 2024-04-19 | 버지니아 커먼웰스 유니버시티 | 산소첨가된 콜레스테롤 술페이트 (ocs) 의 용도 |
CA2910865C (en) | 2014-07-15 | 2016-11-29 | Isa Odidi | Compositions and methods for reducing overdose |
WO2016025897A1 (en) * | 2014-08-15 | 2016-02-18 | Purdue Pharma L.P. | Acetaminophen-containing analgesic formulations with reduced hepatotoxicity |
CN112569214A (zh) * | 2019-09-29 | 2021-03-30 | 山东大学 | 二烯丙基硫醚在制备预防和/或治疗肝纤维化及肝癌药物中的应用 |
WO2024095178A1 (en) | 2022-11-01 | 2024-05-10 | Janssen Pharmaceutica Nv | Thrombopoietin mimetic for use in the treatment of acute liver failure |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314989A (en) * | 1980-05-07 | 1982-02-09 | Rosen Gerald M | Methionine sulfoxide amflioration of acetaminophen toxicity |
US4307073A (en) * | 1980-08-08 | 1981-12-22 | The Research Foundation Of State University Of New York | Method and composition for reducing the toxicity of acetaminophen |
-
1992
- 1992-10-16 US US07/962,529 patent/US5474757A/en not_active Expired - Fee Related
-
1993
- 1993-10-08 AU AU54420/94A patent/AU5442094A/en not_active Abandoned
- 1993-10-08 WO PCT/US1993/009692 patent/WO1994008628A1/en active Application Filing
- 1993-10-14 MX MX9306392A patent/MX9306392A/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO1994008628A1 (en) | 1994-04-28 |
AU5442094A (en) | 1994-05-09 |
US5474757A (en) | 1995-12-12 |
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