MX9306337A - INDOLIN-2-ONAS TRICICLICAS Y TETRACICLICAS 3,3-DISUSTITUIDAS AND COMPARISONS PHARMACEUTICAL THAT CONTAIN THEM, FOR THE TREATMENT OF DISORDERS OF KNOWLEDGE. - Google Patents

INDOLIN-2-ONAS TRICICLICAS Y TETRACICLICAS 3,3-DISUSTITUIDAS AND COMPARISONS PHARMACEUTICAL THAT CONTAIN THEM, FOR THE TREATMENT OF DISORDERS OF KNOWLEDGE.

Info

Publication number
MX9306337A
MX9306337A MX9306337A MX9306337A MX9306337A MX 9306337 A MX9306337 A MX 9306337A MX 9306337 A MX9306337 A MX 9306337A MX 9306337 A MX9306337 A MX 9306337A MX 9306337 A MX9306337 A MX 9306337A
Authority
MX
Mexico
Prior art keywords
disorders
knowledge
treatment
triciclicas
tetraciclicas
Prior art date
Application number
MX9306337A
Other languages
Spanish (es)
Inventor
Richard Alan Earl
Melvin John Myers
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of MX9306337A publication Critical patent/MX9306337A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona con compuestos de la fórmula I, loscuales se ha demostrado que favorecen la liberación del neurotransmisoracetilcolina, y por lo tanto, pueden ser útiles como intermediariosquímicos y como agentes farmacológicos en el tratamiento de enfermedadesen seres humanos, tal como la Enfermedad Aizheimer y otros trastornos queincluyen el aprendizaje y el conocimiento, en los que se encuentranconcentraciones subnormales de este neuroquímico. Los compuestos de lapresente invención tienen la fórmula. (Ver Fórmula).The present invention relates to compounds of formula I, which have been shown to promote the release of the neurotransmitter acetylcholine, and therefore may be useful as chemical intermediates and as pharmacological agents in the treatment of diseases in humans, such as Aizheimer's Disease and other disorders that include learning and knowledge, in which subnormal concentrations of this neurochemical are found. The compounds of the present invention have the formula. (See Formula).

MX9306337A 1992-10-13 1993-10-12 INDOLIN-2-ONAS TRICICLICAS Y TETRACICLICAS 3,3-DISUSTITUIDAS AND COMPARISONS PHARMACEUTICAL THAT CONTAIN THEM, FOR THE TREATMENT OF DISORDERS OF KNOWLEDGE. MX9306337A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96052292A 1992-10-13 1992-10-13

Publications (1)

Publication Number Publication Date
MX9306337A true MX9306337A (en) 1995-01-31

Family

ID=25503278

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9306337A MX9306337A (en) 1992-10-13 1993-10-12 INDOLIN-2-ONAS TRICICLICAS Y TETRACICLICAS 3,3-DISUSTITUIDAS AND COMPARISONS PHARMACEUTICAL THAT CONTAIN THEM, FOR THE TREATMENT OF DISORDERS OF KNOWLEDGE.

Country Status (8)

Country Link
EP (1) EP0664810A1 (en)
JP (1) JPH08502293A (en)
AU (1) AU6242294A (en)
CA (1) CA2146000A1 (en)
IL (1) IL107251A0 (en)
MX (1) MX9306337A (en)
WO (1) WO1994009009A1 (en)
ZA (1) ZA937604B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112624972A (en) * 2019-09-24 2021-04-09 中国人民解放军军事科学院军事医学研究院 Acridone compound and medical application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
US5278045A (en) * 1990-02-28 1994-01-11 Du Pont Merck Pharmaceutical Company Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function

Also Published As

Publication number Publication date
AU6242294A (en) 1994-05-09
JPH08502293A (en) 1996-03-12
ZA937604B (en) 1995-04-13
WO1994009009A1 (en) 1994-04-28
CA2146000A1 (en) 1994-04-28
IL107251A0 (en) 1994-01-25
EP0664810A1 (en) 1995-08-02

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