MX9305713A - RESTORATION OF IMMUNOCOMPETENCE TO T AUXILIARY CELLS IN PATIENTS INFECTED WITH HIV. - Google Patents

RESTORATION OF IMMUNOCOMPETENCE TO T AUXILIARY CELLS IN PATIENTS INFECTED WITH HIV.

Info

Publication number
MX9305713A
MX9305713A MX9305713A MX9305713A MX9305713A MX 9305713 A MX9305713 A MX 9305713A MX 9305713 A MX9305713 A MX 9305713A MX 9305713 A MX9305713 A MX 9305713A MX 9305713 A MX9305713 A MX 9305713A
Authority
MX
Mexico
Prior art keywords
immunocompetence
hiv
restoration
patients infected
auxiliary cells
Prior art date
Application number
MX9305713A
Other languages
Spanish (es)
Inventor
Mario Clerici
Robert L Coffman
Gene M Shearer
Original Assignee
Schering Corp
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Us Health filed Critical Schering Corp
Publication of MX9305713A publication Critical patent/MX9305713A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Esta invención se relaciona con el uso de antagonistas para IL-10 tales como los anticuerpos anti-IL-10 para administración farmacéutica a pacientes infectado con un virus de inmunodeficiencia . La administración de estos anticuerpos restablece la capacidad de las células auxiliares T para producir IL-2.This invention relates to the use of antagonists for IL-10 such as anti-IL-10 antibodies for pharmaceutical administration to patients infected with an immunodeficiency virus. Administration of these antibodies restores the ability of T helper cells to produce IL-2.

MX9305713A 1992-09-18 1993-09-17 RESTORATION OF IMMUNOCOMPETENCE TO T AUXILIARY CELLS IN PATIENTS INFECTED WITH HIV. MX9305713A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94731692A 1992-09-18 1992-09-18

Publications (1)

Publication Number Publication Date
MX9305713A true MX9305713A (en) 1994-05-31

Family

ID=25485948

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9305713A MX9305713A (en) 1992-09-18 1993-09-17 RESTORATION OF IMMUNOCOMPETENCE TO T AUXILIARY CELLS IN PATIENTS INFECTED WITH HIV.

Country Status (6)

Country Link
EP (1) EP0667789A1 (en)
JP (1) JPH08501549A (en)
AU (1) AU4856793A (en)
CA (1) CA2144648A1 (en)
MX (1) MX9305713A (en)
WO (1) WO1994006473A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19529026C2 (en) * 1995-07-28 1997-06-19 Robert Sabat Monoclonal antibodies against human interleukin-10
WO1998010792A1 (en) * 1996-09-11 1998-03-19 Prendergast Patrick T Immune direction therapy
DE19939653A1 (en) * 1999-08-13 2001-02-22 Thomas Huenig Use of CD28 specific monoclonal antibodies for the production of a pharmaceutical composition
US20020114781A1 (en) 2000-09-14 2002-08-22 Strom Terry B. Modulation of IL-2- and IL-15-mediated T cell responses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94878A (en) * 1989-06-28 2003-01-12 Schering Corp Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same
ES2138976T3 (en) * 1991-08-06 2000-02-01 Schering Corp USE OF INTERLEUKIN-10 ANALOGS OR ANTAGONISTS TO TREAT ENDOTOXIN OR SUPERANTIGEN INDUCED TOXICITY.

Also Published As

Publication number Publication date
JPH08501549A (en) 1996-02-20
WO1994006473A1 (en) 1994-03-31
EP0667789A1 (en) 1995-08-23
CA2144648A1 (en) 1994-03-31
AU4856793A (en) 1994-04-12

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