MX9304355A - HETERO CYCLIC COMPOUNDS. - Google Patents

HETERO CYCLIC COMPOUNDS.

Info

Publication number
MX9304355A
MX9304355A MX9304355A MX9304355A MX9304355A MX 9304355 A MX9304355 A MX 9304355A MX 9304355 A MX9304355 A MX 9304355A MX 9304355 A MX9304355 A MX 9304355A MX 9304355 A MX9304355 A MX 9304355A
Authority
MX
Mexico
Prior art keywords
cyclic compounds
hetero cyclic
indoles
relates
present
Prior art date
Application number
MX9304355A
Other languages
Spanish (es)
Inventor
Nagaraja Kodanda Ranganath Rao
Laddawan Chunchatprasert
Karl Witold Franzmann
Jeremy Nigel Stables
Patrick Vivian Richard Shannon
Original Assignee
Wellcome Found
Univ Cardiff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found, Univ Cardiff filed Critical Wellcome Found
Publication of MX9304355A publication Critical patent/MX9304355A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos heterocíclicos que se ha descubierto que tienen una actividad antitumoral. Más específicamente, la presente invención se refiere a pirrolo (3, 2,-b)carbazoles, 1H-benzofuro (3,2f)indoles, y 1H-[1]benzotieno[2, 3-f]indoles, a mètodos para su preparación, a formulaciones farmacéuticas que los contienen, y a su uso como agentes antitumorales.The present invention relates to heterocyclic compounds that have been found to have antitumor activity. More specifically, the present invention relates to pyrrolo (3, 2, -b) carbazoles, 1H-benzofuro (3,2f) indoles, and 1H- [1] benzothiene [2, 3-f] indoles, to methods for their preparation, to pharmaceutical formulations containing them, and to their use as antitumor agents.

MX9304355A 1992-07-20 1993-07-19 HETERO CYCLIC COMPOUNDS. MX9304355A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929215361A GB9215361D0 (en) 1992-07-20 1992-07-20 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
MX9304355A true MX9304355A (en) 1994-04-29

Family

ID=10718981

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304355A MX9304355A (en) 1992-07-20 1993-07-19 HETERO CYCLIC COMPOUNDS.

Country Status (23)

Country Link
EP (1) EP0651750A1 (en)
JP (1) JPH08502037A (en)
KR (1) KR950702563A (en)
CN (1) CN1088209A (en)
AU (1) AU4579593A (en)
BG (1) BG99359A (en)
CA (1) CA2140662A1 (en)
CZ (1) CZ14995A3 (en)
FI (1) FI950229A (en)
GB (1) GB9215361D0 (en)
HR (1) HRP931066A2 (en)
HU (1) HUT76787A (en)
IL (1) IL106385A0 (en)
MX (1) MX9304355A (en)
NO (1) NO950202D0 (en)
NZ (1) NZ254207A (en)
PL (1) PL307169A1 (en)
RU (1) RU95104939A (en)
SI (1) SI9300390A (en)
SK (1) SK7595A3 (en)
WO (1) WO1994002483A1 (en)
YU (1) YU50293A (en)
ZA (1) ZA935213B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9401921D0 (en) * 1994-02-01 1994-03-30 Wellcome Found Heterocyclic compounds
GB9413758D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Heterocyclic compounds
GB9804343D0 (en) * 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
US7419992B2 (en) 2001-02-14 2008-09-02 Wisconsin Alumni Research Foundation Use of aryl hydrocarbon receptor ligand as a therapeutic intervention in angiogenesis-implicated disorders
ATE431823T1 (en) * 2001-02-14 2009-06-15 Wisconsin Alumni Res Found PREPARATIONS AND USE OF AH RECEPTOR LIGAND, 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID METHYL ESTER
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
WO2008051523A2 (en) * 2006-10-23 2008-05-02 Georgetown University Carbazole derivatives useful as medicaments in cancer therapy
CA2734225A1 (en) 2008-08-15 2010-02-18 Georgetown University Fluorescent regulators of rassf1a expression and human cancer cell proliferation
JP2012051804A (en) * 2008-12-26 2012-03-15 Kyoto Univ Eg5 INHIBITOR
KR20160066490A (en) 2014-12-02 2016-06-10 주식회사 씨앤드씨신약연구소 Heterocyclic derivatives and use thereof
US11053255B2 (en) 2015-06-22 2021-07-06 Georgetown University Synthesis of mahanine and related compounds
CN109776550B (en) * 2019-01-17 2021-08-10 广东轻工职业技术学院 Alkaloid compound derived from marine fungi and application thereof in preparation of food preservative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300688A1 (en) * 1987-07-21 1989-01-25 FISONS plc Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them
GB2239013B (en) * 1989-11-01 1993-06-02 Toyama Chemical Co Ltd Novel isoindole derivatives and salts thereof,processes for producing the same and antitumor agent comprising the same
WO1991014688A1 (en) * 1990-03-20 1991-10-03 The Wellcome Foundation Limited Hetero polycyclic biocidal compounds and their use in medecine

Also Published As

Publication number Publication date
HRP931066A2 (en) 1995-12-31
NO950202L (en) 1995-01-19
CA2140662A1 (en) 1994-02-03
ZA935213B (en) 1995-01-19
HUT76787A (en) 1997-11-28
FI950229A (en) 1995-03-10
KR950702563A (en) 1995-07-29
YU50293A (en) 1997-01-08
AU4579593A (en) 1994-02-14
JPH08502037A (en) 1996-03-05
NO950202D0 (en) 1995-01-19
FI950229A0 (en) 1995-01-19
CZ14995A3 (en) 1995-10-18
WO1994002483A1 (en) 1994-02-03
HU9500171D0 (en) 1995-03-28
SI9300390A (en) 1994-03-31
CN1088209A (en) 1994-06-22
PL307169A1 (en) 1995-05-15
RU95104939A (en) 1996-10-27
EP0651750A1 (en) 1995-05-10
NZ254207A (en) 1997-03-24
GB9215361D0 (en) 1992-09-02
IL106385A0 (en) 1993-11-15
BG99359A (en) 1995-11-30
SK7595A3 (en) 1995-07-11

Similar Documents

Publication Publication Date Title
MX9304355A (en) HETERO CYCLIC COMPOUNDS.
ES2144192T3 (en) NEW DERIVATIVES OF 1-PHENYL-2-DIMETHYL-AMINO-METHYL-CICLOHEXAN-1-OL, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
SE8602723L (en) TIAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR008630A1 (en) INDOL-3-GLIOXILAMIDAS N-SUBSTITUTED WITH ANTI-ASMATIC, ANTI-ALLERGIC AND IMMUNOSUPPRESSOR / IMMUNOMODULATOR EFFECTS, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL STRUCTURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE69804743D1 (en) Pyrazolo [4,3-d] pyrimidine derivatives and pharmaceutical preparations containing them
CO5271700A1 (en) PHARMACEUTICAL COMPOSITION THAT INCLUDES ACID 3- [2,4-DIMETHYL-5- (2-OXO-1,2-DIHIDRO-INDOL-3-ILIDENMETIL) -1H-PIRROL-3-IL] -PROPIONIC, ONE OR MORE POLYHYDROCARBIL COMPOUNDS AND A PHARMACEUTICALLY ACCEPTABLE VEHICLE
EE03177B1 (en) Heterobicyclic compounds, methods for their preparation and pharmaceutical compositions containing said compounds
EE9400428A (en) Isatin derivatives, their preparation process, formulations containing them and their use
NO962073D0 (en) Amphiphilic imidazolinium derivatives
NO853046L (en) PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE INDOL DERIVATIVES.
MX9300407A (en) AZABICICLIC DERIVATIVES USED IN THE MANUFACTURE OF MEDICINES, CONTAINING COMPOSITIONS AND PROCEDURE FOR THE PREPARATION.
TR199801861T2 (en) Pharmaceutically useful compositions.
NO884174D0 (en) PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE TRICYCLIC AMIDINO DERIVATIVES.
HUP0302635A2 (en) Phospholipid derivatives of valproic acid and mixtures thereof
ES2103311T3 (en) HETERO CYCLIC COMPOUNDS.
ES2161718T3 (en) 2,5-DIOXO-2,5-DIHIDRO-1H-BENZO (B) AZEPINAS AS ANTAGONISTS OF NMDA RECEPTORS.
SE7808770L (en) PYRIDO (1,2-A) PYRIMIDINE DERIVATIVES AS WELL AS THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
ES2057225T3 (en) A COMPOSITION FOR THE PREPARATION OF AN ACTIVE VITAMIN D3 IN A DOSAGE FORM AND ITS PREPARATION PROCEDURE.
IT8049899A0 (en) DIAZEPINE COMPOUNDS FOR PHARMACEUTICAL USE AND THEIR PREPARATION PROCEDURE
ES2127263T3 (en) NEW TRIEN-CHROMENIC DERIVATIVES, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
ES2297837T3 (en) DERIVATIVES OF 1,3-DIHIDRO-1- (FENILALQUENIL) -2H-IMIDAZOL-2-ONA THAT HAVE INHIBITING ACTIVITY OF PDE IV AND CYTOQUINE.
ES2148458T3 (en) DERIVATIVES OF FENIL-4-THIAZOLES SUBSTITUTED, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
SE8302979L (en) PIPERAZINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE
SE8302580D0 (en) SUBSTITUTED IMINO DERIVATIVES OF DIHYDROBENSOPYRANE AND DIHYDROBENZOPYRANE AND PROCEDURE FOR THEIR PREPARATION
NO830900L (en) PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE TRICYCLIC DERIVATIVES.

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees