FI950229A - Tetracyclic compounds, processes and intermediates for their preparation and their use as antitumor agents - Google Patents
Tetracyclic compounds, processes and intermediates for their preparation and their use as antitumor agents Download PDFInfo
- Publication number
- FI950229A FI950229A FI950229A FI950229A FI950229A FI 950229 A FI950229 A FI 950229A FI 950229 A FI950229 A FI 950229A FI 950229 A FI950229 A FI 950229A FI 950229 A FI950229 A FI 950229A
- Authority
- FI
- Finland
- Prior art keywords
- intermediates
- processes
- preparation
- antitumor agents
- tetracyclic compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929215361A GB9215361D0 (en) | 1992-07-20 | 1992-07-20 | Heterocyclic compounds |
| PCT/GB1993/001512 WO1994002483A1 (en) | 1992-07-20 | 1993-07-19 | Tetracyclic compounds process and intermediates for their preparation and their use as antitumour agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI950229A0 FI950229A0 (en) | 1995-01-19 |
| FI950229A true FI950229A (en) | 1995-03-10 |
Family
ID=10718981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI950229A FI950229A (en) | 1992-07-20 | 1995-01-19 | Tetracyclic compounds, processes and intermediates for their preparation and their use as antitumor agents |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0651750A1 (en) |
| JP (1) | JPH08502037A (en) |
| KR (1) | KR950702563A (en) |
| CN (1) | CN1088209A (en) |
| AU (1) | AU4579593A (en) |
| BG (1) | BG99359A (en) |
| CA (1) | CA2140662A1 (en) |
| CZ (1) | CZ14995A3 (en) |
| FI (1) | FI950229A (en) |
| GB (1) | GB9215361D0 (en) |
| HR (1) | HRP931066A2 (en) |
| HU (1) | HUT76787A (en) |
| IL (1) | IL106385A0 (en) |
| MX (1) | MX9304355A (en) |
| NO (1) | NO950202D0 (en) |
| NZ (1) | NZ254207A (en) |
| PL (1) | PL307169A1 (en) |
| RU (1) | RU95104939A (en) |
| SI (1) | SI9300390A (en) |
| SK (1) | SK7595A3 (en) |
| WO (1) | WO1994002483A1 (en) |
| YU (1) | YU50293A (en) |
| ZA (1) | ZA935213B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9401921D0 (en) * | 1994-02-01 | 1994-03-30 | Wellcome Found | Heterocyclic compounds |
| GB9413758D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Heterocyclic compounds |
| GB9804343D0 (en) * | 1998-02-27 | 1998-04-22 | Univ Cardiff | Chemical compounds |
| US7419992B2 (en) | 2001-02-14 | 2008-09-02 | Wisconsin Alumni Research Foundation | Use of aryl hydrocarbon receptor ligand as a therapeutic intervention in angiogenesis-implicated disorders |
| ATE431823T1 (en) * | 2001-02-14 | 2009-06-15 | Wisconsin Alumni Res Found | PREPARATIONS AND USE OF AH RECEPTOR LIGAND, 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID METHYL ESTER |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| WO2008051523A2 (en) * | 2006-10-23 | 2008-05-02 | Georgetown University | Carbazole derivatives useful as medicaments in cancer therapy |
| CA2734225A1 (en) | 2008-08-15 | 2010-02-18 | Georgetown University | Fluorescent regulators of rassf1a expression and human cancer cell proliferation |
| JP2012051804A (en) * | 2008-12-26 | 2012-03-15 | Kyoto Univ | Eg5 INHIBITOR |
| KR20160066490A (en) | 2014-12-02 | 2016-06-10 | 주식회사 씨앤드씨신약연구소 | Heterocyclic derivatives and use thereof |
| US11053255B2 (en) | 2015-06-22 | 2021-07-06 | Georgetown University | Synthesis of mahanine and related compounds |
| CN109776550B (en) * | 2019-01-17 | 2021-08-10 | 广东轻工职业技术学院 | Alkaloid compound derived from marine fungi and application thereof in preparation of food preservative |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0300688A1 (en) * | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them |
| GB2239013B (en) * | 1989-11-01 | 1993-06-02 | Toyama Chemical Co Ltd | Novel isoindole derivatives and salts thereof,processes for producing the same and antitumor agent comprising the same |
| WO1991014688A1 (en) * | 1990-03-20 | 1991-10-03 | The Wellcome Foundation Limited | Hetero polycyclic biocidal compounds and their use in medecine |
-
1992
- 1992-07-20 GB GB929215361A patent/GB9215361D0/en active Pending
-
1993
- 1993-07-19 WO PCT/GB1993/001512 patent/WO1994002483A1/en not_active Application Discontinuation
- 1993-07-19 RU RU95104939/04A patent/RU95104939A/en unknown
- 1993-07-19 SI SI9300390A patent/SI9300390A/en unknown
- 1993-07-19 JP JP6504272A patent/JPH08502037A/en active Pending
- 1993-07-19 ZA ZA935213A patent/ZA935213B/en unknown
- 1993-07-19 KR KR1019950700226A patent/KR950702563A/en not_active Application Discontinuation
- 1993-07-19 EP EP93916105A patent/EP0651750A1/en not_active Withdrawn
- 1993-07-19 SK SK75-95A patent/SK7595A3/en unknown
- 1993-07-19 PL PL93307169A patent/PL307169A1/en unknown
- 1993-07-19 CZ CZ95149A patent/CZ14995A3/en unknown
- 1993-07-19 MX MX9304355A patent/MX9304355A/en not_active IP Right Cessation
- 1993-07-19 IL IL106385A patent/IL106385A0/en unknown
- 1993-07-19 CA CA002140662A patent/CA2140662A1/en not_active Abandoned
- 1993-07-19 AU AU45795/93A patent/AU4579593A/en not_active Abandoned
- 1993-07-19 CN CN93116598A patent/CN1088209A/en active Pending
- 1993-07-19 HR HR931066A patent/HRP931066A2/en not_active Application Discontinuation
- 1993-07-19 NZ NZ254207A patent/NZ254207A/en unknown
- 1993-07-19 HU HU9500171A patent/HUT76787A/en unknown
- 1993-07-20 YU YU50293A patent/YU50293A/en unknown
-
1995
- 1995-01-18 BG BG99359A patent/BG99359A/en unknown
- 1995-01-19 NO NO950202A patent/NO950202D0/en unknown
- 1995-01-19 FI FI950229A patent/FI950229A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP931066A2 (en) | 1995-12-31 |
| NO950202L (en) | 1995-01-19 |
| CA2140662A1 (en) | 1994-02-03 |
| ZA935213B (en) | 1995-01-19 |
| HUT76787A (en) | 1997-11-28 |
| KR950702563A (en) | 1995-07-29 |
| MX9304355A (en) | 1994-04-29 |
| YU50293A (en) | 1997-01-08 |
| AU4579593A (en) | 1994-02-14 |
| JPH08502037A (en) | 1996-03-05 |
| NO950202D0 (en) | 1995-01-19 |
| FI950229A0 (en) | 1995-01-19 |
| CZ14995A3 (en) | 1995-10-18 |
| WO1994002483A1 (en) | 1994-02-03 |
| HU9500171D0 (en) | 1995-03-28 |
| SI9300390A (en) | 1994-03-31 |
| CN1088209A (en) | 1994-06-22 |
| PL307169A1 (en) | 1995-05-15 |
| RU95104939A (en) | 1996-10-27 |
| EP0651750A1 (en) | 1995-05-10 |
| NZ254207A (en) | 1997-03-24 |
| GB9215361D0 (en) | 1992-09-02 |
| IL106385A0 (en) | 1993-11-15 |
| BG99359A (en) | 1995-11-30 |
| SK7595A3 (en) | 1995-07-11 |
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