MX9303799A - DERIVATIVES OF THE VITAMIN D SERIES WITH MODIFICATIONS IN POSITION 20, PROCEDURE FOR ITS PREPARATION, INTERMEDIATE PRODUCTS FOR THIS PROCEDURE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS WELL AS THEIR USE FOR THE PROD. - Google Patents
DERIVATIVES OF THE VITAMIN D SERIES WITH MODIFICATIONS IN POSITION 20, PROCEDURE FOR ITS PREPARATION, INTERMEDIATE PRODUCTS FOR THIS PROCEDURE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS WELL AS THEIR USE FOR THE PROD.Info
- Publication number
- MX9303799A MX9303799A MX9303799A MX9303799A MX9303799A MX 9303799 A MX9303799 A MX 9303799A MX 9303799 A MX9303799 A MX 9303799A MX 9303799 A MX9303799 A MX 9303799A MX 9303799 A MX9303799 A MX 9303799A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- procedure
- vitamin
- well
- prod
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000013067 intermediate product Substances 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
- C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to vitamin D derivatives, modified in 20-position, of general formula I <IMAGE> I in which X, Y, Z, R1, R2 as well as R3 have the meaning indicated in the description, process for their production and their use as agents for treatment of hyperproliferative diseases of the skin.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4220757A DE4220757A1 (en) | 1992-06-24 | 1992-06-24 | Derivatives in the vitamin D series with modifications in the 20-position, process for their preparation, intermediates for this process, pharmaceutical preparations containing these derivatives and their use in the manufacture of medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9303799A true MX9303799A (en) | 1994-07-29 |
Family
ID=6461752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9303799A MX9303799A (en) | 1992-06-24 | 1993-06-24 | DERIVATIVES OF THE VITAMIN D SERIES WITH MODIFICATIONS IN POSITION 20, PROCEDURE FOR ITS PREPARATION, INTERMEDIATE PRODUCTS FOR THIS PROCEDURE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS WELL AS THEIR USE FOR THE PROD. |
Country Status (24)
Country | Link |
---|---|
US (2) | US5585368A (en) |
EP (1) | EP0647219B1 (en) |
JP (1) | JPH08501531A (en) |
KR (1) | KR100300274B1 (en) |
CN (2) | CN1055921C (en) |
AT (1) | ATE140918T1 (en) |
AU (1) | AU679685B2 (en) |
CA (1) | CA2138989A1 (en) |
CZ (1) | CZ282151B6 (en) |
DE (2) | DE4220757A1 (en) |
DK (1) | DK0647219T3 (en) |
ES (1) | ES2093440T3 (en) |
FI (1) | FI111720B (en) |
GR (1) | GR3020974T3 (en) |
HU (1) | HUT70563A (en) |
IL (1) | IL106128A0 (en) |
MX (1) | MX9303799A (en) |
NO (1) | NO306614B1 (en) |
NZ (1) | NZ253698A (en) |
PL (1) | PL174024B1 (en) |
SK (1) | SK281244B6 (en) |
TW (1) | TW255883B (en) |
WO (1) | WO1994000428A1 (en) |
ZA (1) | ZA934550B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5830885A (en) * | 1992-03-12 | 1998-11-03 | The Johns Hopkins University | Antiproliferative vitamin D3 hybrids |
AU666563B2 (en) * | 1992-08-07 | 1996-02-15 | Wisconsin Alumni Research Foundation | Preparation of 19-nor-vitamin D compounds |
US5449668A (en) * | 1993-06-04 | 1995-09-12 | Duphar International Research B.V. | Vitamin D compounds and method of preparing these compounds |
IL112759A0 (en) * | 1994-02-25 | 1995-05-26 | Khepri Pharmaceuticals Inc | Novel cysteine protease inhibitors |
ES2150560T3 (en) * | 1994-04-11 | 2000-12-01 | Chugai Pharmaceutical Co Ltd | DERIVED FROM 22-TIAVITAMINE D3. |
EP0717034B1 (en) * | 1994-12-14 | 1999-04-07 | Duphar International Research B.V | Vitamin D compounds and method of preparing these compounds |
US6242434B1 (en) | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
IL118156A (en) * | 1995-05-09 | 2001-08-26 | Duphar Int Res | Vitamin d compounds, their preparation and pharmaceutical compositions containing them |
DE19619036A1 (en) | 1996-04-30 | 1997-11-13 | Schering Ag | New vitamin D derivatives with carbo- or heterocyclic substituents at C-25, process for their preparation and their use in the manufacture of medicinal products |
SG70010A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Fluorinated vitamin d3 analogs |
AU743399B2 (en) * | 1997-06-25 | 2002-01-24 | Teijin Limited | Vitamin d3 derivatives and remedies for inflammatory respiratory diseases prepared from the same |
ATE238986T1 (en) | 1997-09-08 | 2003-05-15 | Hoffmann La Roche | 1,3-DIHYDROXY-20,20-DIALKYL VITAMIN D3 ANALOGUE |
DE19744127B4 (en) * | 1997-10-01 | 2006-10-05 | Schering Ag | New vitamin D derivatives with side-chain cyclopropyl rings, processes and intermediates for their preparation and their use in the manufacture of medicaments |
US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
DE19935771A1 (en) * | 1999-07-23 | 2001-02-01 | Schering Ag | New vitamin D derivatives with cyclic substructures in the side chains, processes and intermediates for their manufacture and their use in the manufacture of pharmaceuticals |
EP1314427A4 (en) * | 2000-08-17 | 2006-05-03 | Chugai Pharmaceutical Co Ltd | Remedial agent for osteoporosis |
US7491711B2 (en) * | 2001-09-21 | 2009-02-17 | Roche Palo Alto Llc | Methods of treatment using 3-desoxy vitamin D3 analogs |
EP1458678A1 (en) * | 2002-11-18 | 2004-09-22 | Teva Pharmaceutical Industries Limited | A crystallization method for purification of calcipotriene |
US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
US20090298800A1 (en) * | 2005-09-23 | 2009-12-03 | Bioxell S.P.A. | 1,25-dihydroxy, 20-cyclopropyl,26-27-deuteroalkyl vitamin d3 compounds and methods of use thereof |
EP2043682B1 (en) | 2006-07-17 | 2014-04-02 | GlaxoSmithKline Biologicals S.A. | Influenza vaccine |
US7888339B2 (en) | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
SG173119A1 (en) | 2009-01-27 | 2011-08-29 | Berg Biosystems Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
CN106265695B (en) | 2009-08-14 | 2021-05-07 | 博格有限责任公司 | Vitamin D3 and analogs thereof for the treatment of alopecia |
CN103073607B (en) * | 2013-02-26 | 2014-09-03 | 昆明理工大学 | 12[beta]-hydroxyandrostane-4,6,8(9),13(14)-tetraene-3,11,16-triketone and application thereof |
CN103073608B (en) * | 2013-02-26 | 2014-09-03 | 昆明理工大学 | Androstane-4, 6, 8 (9), 13 (14)-tetraene-3, 11, 16-triketone and application thereof |
SG10201709894RA (en) | 2013-05-29 | 2018-01-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
US10548908B2 (en) * | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4617297A (en) * | 1982-02-12 | 1986-10-14 | Hoffmann-La Roche Inc. | Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol |
US4594432A (en) * | 1983-01-28 | 1986-06-10 | Hoffman-La Roche Inc. | Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol |
US4719205A (en) * | 1984-01-30 | 1988-01-12 | Wisconsin Alumini Research Foundation | Side-chain unsaturated 1-hydroxyvitamin D compounds |
JPS6144860A (en) * | 1984-08-10 | 1986-03-04 | Taisho Pharmaceut Co Ltd | 1alpha, 25-dihydroxy-26,27-dimethylvitamin d3 |
CA1332841C (en) * | 1984-11-27 | 1994-11-01 | Noboru Kubodera | Vitamin d derivatives and process for producing the same |
US4612308A (en) * | 1984-11-29 | 1986-09-16 | Hoffmann-La Roche Inc. | 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers |
EP0205285B1 (en) * | 1985-05-30 | 1989-08-09 | Taisho Pharmaceutical Co. Ltd | Vitamin d3 derivatives |
WO1987003282A1 (en) * | 1985-11-21 | 1987-06-04 | Taisho Pharmaceutical Co., Ltd. | Vitamin d3 derivative |
US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
US4851401A (en) * | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
US4970203A (en) * | 1988-12-09 | 1990-11-13 | Deluca Hector F | Method for improving reproductive functions in mammals |
NZ232734A (en) * | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
GB8915770D0 (en) * | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
DE4011682A1 (en) * | 1990-04-06 | 1991-10-10 | Schering Ag | 24-OXA DERIVATIVES IN THE VITAMIN D SERIES |
DE69213844T2 (en) * | 1991-07-05 | 1997-04-10 | Duphar Int Res | Vitamin D derivative, process for its production and intermediates therefor |
DE4141746A1 (en) * | 1991-12-13 | 1993-06-17 | Schering Ag | 20-METHYL-SUBSTITUTED VITAMIN D DERIVATIVES |
US5200536A (en) * | 1992-02-10 | 1993-04-06 | Daikin Industries Ltd. | Fluorine-containing vitamin D3 analogues |
US5194431A (en) * | 1992-07-08 | 1993-03-16 | Wisconsin Alumni Research Foundation | 24-cyclopropane vitamin D derivatives |
IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
-
1992
- 1992-06-24 DE DE4220757A patent/DE4220757A1/en not_active Withdrawn
-
1993
- 1993-06-23 CN CN93107406A patent/CN1055921C/en not_active Expired - Fee Related
- 1993-06-24 US US08/080,841 patent/US5585368A/en not_active Expired - Fee Related
- 1993-06-24 SK SK1584-94A patent/SK281244B6/en unknown
- 1993-06-24 DK DK93914720.3T patent/DK0647219T3/en active
- 1993-06-24 PL PL93306813A patent/PL174024B1/en not_active IP Right Cessation
- 1993-06-24 HU HU9403771A patent/HUT70563A/en unknown
- 1993-06-24 EP EP93914720A patent/EP0647219B1/en not_active Expired - Lifetime
- 1993-06-24 KR KR1019940704723A patent/KR100300274B1/en not_active IP Right Cessation
- 1993-06-24 JP JP6502048A patent/JPH08501531A/en active Pending
- 1993-06-24 CZ CZ943276A patent/CZ282151B6/en not_active IP Right Cessation
- 1993-06-24 CA CA002138989A patent/CA2138989A1/en not_active Abandoned
- 1993-06-24 ZA ZA934550A patent/ZA934550B/en unknown
- 1993-06-24 IL IL106128A patent/IL106128A0/en unknown
- 1993-06-24 NZ NZ253698A patent/NZ253698A/en unknown
- 1993-06-24 AT AT93914720T patent/ATE140918T1/en not_active IP Right Cessation
- 1993-06-24 ES ES93914720T patent/ES2093440T3/en not_active Expired - Lifetime
- 1993-06-24 WO PCT/EP1993/001620 patent/WO1994000428A1/en active IP Right Grant
- 1993-06-24 MX MX9303799A patent/MX9303799A/en not_active IP Right Cessation
- 1993-06-24 DE DE59303365T patent/DE59303365D1/en not_active Expired - Lifetime
- 1993-06-24 AU AU45007/93A patent/AU679685B2/en not_active Ceased
- 1993-08-12 TW TW082106461A patent/TW255883B/zh not_active IP Right Cessation
-
1994
- 1994-12-23 NO NO945034A patent/NO306614B1/en unknown
- 1994-12-23 FI FI946073A patent/FI111720B/en not_active IP Right Cessation
-
1996
- 1996-06-14 US US08/664,121 patent/US5700791A/en not_active Expired - Fee Related
- 1996-09-06 GR GR960402337T patent/GR3020974T3/en unknown
-
1999
- 1999-12-23 CN CNB991264738A patent/CN1173909C/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
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FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |