MX9303799A - DERIVATIVES OF THE VITAMIN D SERIES WITH MODIFICATIONS IN POSITION 20, PROCEDURE FOR ITS PREPARATION, INTERMEDIATE PRODUCTS FOR THIS PROCEDURE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS WELL AS THEIR USE FOR THE PROD. - Google Patents

DERIVATIVES OF THE VITAMIN D SERIES WITH MODIFICATIONS IN POSITION 20, PROCEDURE FOR ITS PREPARATION, INTERMEDIATE PRODUCTS FOR THIS PROCEDURE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS WELL AS THEIR USE FOR THE PROD.

Info

Publication number
MX9303799A
MX9303799A MX9303799A MX9303799A MX9303799A MX 9303799 A MX9303799 A MX 9303799A MX 9303799 A MX9303799 A MX 9303799A MX 9303799 A MX9303799 A MX 9303799A MX 9303799 A MX9303799 A MX 9303799A
Authority
MX
Mexico
Prior art keywords
derivatives
procedure
vitamin
well
prod
Prior art date
Application number
MX9303799A
Other languages
Spanish (es)
Inventor
Katica Schwarz
Ruth Thieroff
Herbert Wiesinger
Martin Haberey
Andreas Steinmeyer
Guenter Neef
Gerald Kirsch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MX9303799A publication Critical patent/MX9303799A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to vitamin D derivatives, modified in 20-position, of general formula I <IMAGE> I in which X, Y, Z, R1, R2 as well as R3 have the meaning indicated in the description, process for their production and their use as agents for treatment of hyperproliferative diseases of the skin.
MX9303799A 1992-06-24 1993-06-24 DERIVATIVES OF THE VITAMIN D SERIES WITH MODIFICATIONS IN POSITION 20, PROCEDURE FOR ITS PREPARATION, INTERMEDIATE PRODUCTS FOR THIS PROCEDURE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS WELL AS THEIR USE FOR THE PROD. MX9303799A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4220757A DE4220757A1 (en) 1992-06-24 1992-06-24 Derivatives in the vitamin D series with modifications in the 20-position, process for their preparation, intermediates for this process, pharmaceutical preparations containing these derivatives and their use in the manufacture of medicaments

Publications (1)

Publication Number Publication Date
MX9303799A true MX9303799A (en) 1994-07-29

Family

ID=6461752

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9303799A MX9303799A (en) 1992-06-24 1993-06-24 DERIVATIVES OF THE VITAMIN D SERIES WITH MODIFICATIONS IN POSITION 20, PROCEDURE FOR ITS PREPARATION, INTERMEDIATE PRODUCTS FOR THIS PROCEDURE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS WELL AS THEIR USE FOR THE PROD.

Country Status (24)

Country Link
US (2) US5585368A (en)
EP (1) EP0647219B1 (en)
JP (1) JPH08501531A (en)
KR (1) KR100300274B1 (en)
CN (2) CN1055921C (en)
AT (1) ATE140918T1 (en)
AU (1) AU679685B2 (en)
CA (1) CA2138989A1 (en)
CZ (1) CZ282151B6 (en)
DE (2) DE4220757A1 (en)
DK (1) DK0647219T3 (en)
ES (1) ES2093440T3 (en)
FI (1) FI111720B (en)
GR (1) GR3020974T3 (en)
HU (1) HUT70563A (en)
IL (1) IL106128A0 (en)
MX (1) MX9303799A (en)
NO (1) NO306614B1 (en)
NZ (1) NZ253698A (en)
PL (1) PL174024B1 (en)
SK (1) SK281244B6 (en)
TW (1) TW255883B (en)
WO (1) WO1994000428A1 (en)
ZA (1) ZA934550B (en)

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US5830885A (en) * 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
IL112759A0 (en) * 1994-02-25 1995-05-26 Khepri Pharmaceuticals Inc Novel cysteine protease inhibitors
ES2150560T3 (en) * 1994-04-11 2000-12-01 Chugai Pharmaceutical Co Ltd DERIVED FROM 22-TIAVITAMINE D3.
EP0717034B1 (en) * 1994-12-14 1999-04-07 Duphar International Research B.V Vitamin D compounds and method of preparing these compounds
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them
DE19619036A1 (en) 1996-04-30 1997-11-13 Schering Ag New vitamin D derivatives with carbo- or heterocyclic substituents at C-25, process for their preparation and their use in the manufacture of medicinal products
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
AU743399B2 (en) * 1997-06-25 2002-01-24 Teijin Limited Vitamin d3 derivatives and remedies for inflammatory respiratory diseases prepared from the same
ATE238986T1 (en) 1997-09-08 2003-05-15 Hoffmann La Roche 1,3-DIHYDROXY-20,20-DIALKYL VITAMIN D3 ANALOGUE
DE19744127B4 (en) * 1997-10-01 2006-10-05 Schering Ag New vitamin D derivatives with side-chain cyclopropyl rings, processes and intermediates for their preparation and their use in the manufacture of medicaments
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
DE19935771A1 (en) * 1999-07-23 2001-02-01 Schering Ag New vitamin D derivatives with cyclic substructures in the side chains, processes and intermediates for their manufacture and their use in the manufacture of pharmaceuticals
EP1314427A4 (en) * 2000-08-17 2006-05-03 Chugai Pharmaceutical Co Ltd Remedial agent for osteoporosis
US7491711B2 (en) * 2001-09-21 2009-02-17 Roche Palo Alto Llc Methods of treatment using 3-desoxy vitamin D3 analogs
EP1458678A1 (en) * 2002-11-18 2004-09-22 Teva Pharmaceutical Industries Limited A crystallization method for purification of calcipotriene
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20090298800A1 (en) * 2005-09-23 2009-12-03 Bioxell S.P.A. 1,25-dihydroxy, 20-cyclopropyl,26-27-deuteroalkyl vitamin d3 compounds and methods of use thereof
EP2043682B1 (en) 2006-07-17 2014-04-02 GlaxoSmithKline Biologicals S.A. Influenza vaccine
US7888339B2 (en) 2008-07-10 2011-02-15 Wisconsin Alumni Research Foundation 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
SG173119A1 (en) 2009-01-27 2011-08-29 Berg Biosystems Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN106265695B (en) 2009-08-14 2021-05-07 博格有限责任公司 Vitamin D3 and analogs thereof for the treatment of alopecia
CN103073607B (en) * 2013-02-26 2014-09-03 昆明理工大学 12[beta]-hydroxyandrostane-4,6,8(9),13(14)-tetraene-3,11,16-triketone and application thereof
CN103073608B (en) * 2013-02-26 2014-09-03 昆明理工大学 Androstane-4, 6, 8 (9), 13 (14)-tetraene-3, 11, 16-triketone and application thereof
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

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US4617297A (en) * 1982-02-12 1986-10-14 Hoffmann-La Roche Inc. Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol
US4594432A (en) * 1983-01-28 1986-06-10 Hoffman-La Roche Inc. Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (en) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd 1alpha, 25-dihydroxy-26,27-dimethylvitamin d3
CA1332841C (en) * 1984-11-27 1994-11-01 Noboru Kubodera Vitamin d derivatives and process for producing the same
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
EP0205285B1 (en) * 1985-05-30 1989-08-09 Taisho Pharmaceutical Co. Ltd Vitamin d3 derivatives
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US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
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Also Published As

Publication number Publication date
EP0647219B1 (en) 1996-07-31
HU9403771D0 (en) 1995-02-28
SK158494A3 (en) 1995-07-11
CN1173909C (en) 2004-11-03
SK281244B6 (en) 2001-01-18
GR3020974T3 (en) 1996-12-31
WO1994000428A1 (en) 1994-01-06
PL174024B1 (en) 1998-06-30
EP0647219A1 (en) 1995-04-12
AU679685B2 (en) 1997-07-10
KR950702181A (en) 1995-06-19
CN1262267A (en) 2000-08-09
TW255883B (en) 1995-09-01
US5700791A (en) 1997-12-23
CN1055921C (en) 2000-08-30
NZ253698A (en) 1996-11-26
FI946073A0 (en) 1994-12-23
DE59303365D1 (en) 1996-09-05
CZ327694A3 (en) 1995-06-14
KR100300274B1 (en) 2001-11-22
CN1089599A (en) 1994-07-20
NO945034D0 (en) 1994-12-23
IL106128A0 (en) 1993-10-20
CA2138989A1 (en) 1994-01-06
FI946073A (en) 1994-12-23
DE4220757A1 (en) 1994-01-05
DK0647219T3 (en) 1996-12-09
FI111720B (en) 2003-09-15
NO945034L (en) 1995-02-24
HUT70563A (en) 1995-10-30
NO306614B1 (en) 1999-11-29
ZA934550B (en) 1994-01-27
JPH08501531A (en) 1996-02-20
US5585368A (en) 1996-12-17
ATE140918T1 (en) 1996-08-15
AU4500793A (en) 1994-01-24
ES2093440T3 (en) 1996-12-16
CZ282151B6 (en) 1997-05-14

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