ES2163986B1 - ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II. - Google Patents
ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II.Info
- Publication number
- ES2163986B1 ES2163986B1 ES9901628A ES9901628A ES2163986B1 ES 2163986 B1 ES2163986 B1 ES 2163986B1 ES 9901628 A ES9901628 A ES 9901628A ES 9901628 A ES9901628 A ES 9901628A ES 2163986 B1 ES2163986 B1 ES 2163986B1
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- cyclooxygenase
- compounds
- present
- cyclloxygenasa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
Ácidos {al}-arilpropiónicos y arilacéticos como inhibidores de la ciclooxigenasa-II. La presente invención se refiere a compuestos de fórmula general I, **FORMULA** inhibidores selectivos de la ciclooxigenasa-II, a sus sales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contienen. Los compuestos de la presente invención son útiles en el tratamiento de la inflamación, dolor y fiebre, así como de aquellas otras afecciones que recientemente se han asociado con las ciclooxigenasas, especialmente con la ciclooxigenasa-II, como, por ejemplo, el cáncer colorectal y la enfermedad de Alzheimer. De igual modo, la presente invención se refiere a un procedimiento para la preparación de los compuestos, así como a su utilización terapéutica.{Al} -arylpropionic and arylacetic acids as inhibitors of cyclooxygenase-II. The present invention relates to compounds of general formula I, ** FORMULA ** selective inhibitors of cyclooxygenase-II, their pharmaceutically acceptable salts and solvates, and the pharmaceutical compositions containing them. The compounds of the present invention are useful in the treatment of inflammation, pain and fever, as well as those other conditions that have recently been associated with cyclooxygenases, especially with cyclooxygenase-II, such as, for example, colorectal cancer and Alzheimer's disease. Similarly, the present invention relates to a process for the preparation of the compounds, as well as to their therapeutic use.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9901628A ES2163986B1 (en) | 1999-07-13 | 1999-07-13 | ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9901628A ES2163986B1 (en) | 1999-07-13 | 1999-07-13 | ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2163986A1 ES2163986A1 (en) | 2002-02-01 |
ES2163986B1 true ES2163986B1 (en) | 2003-02-16 |
Family
ID=8309292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9901628A Expired - Fee Related ES2163986B1 (en) | 1999-07-13 | 1999-07-13 | ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2163986B1 (en) |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS183613B2 (en) * | 1968-12-20 | 1978-07-31 | Daniel Farge | Method for producing derivatives of 3-benzoylphenyl acetic acid |
GB1307284A (en) * | 1970-03-16 | 1973-02-14 | Boots Co Ltd | 2-substituted phenyl propionic acids |
OA04219A (en) * | 1971-12-03 | 1979-12-31 | Rhone Poulenc Sa | Novel process for the preparation of (3-benzol-phenyl) -2 propionic acid and the like. |
CA1041531A (en) * | 1973-10-29 | 1978-10-31 | Eisai Co. Ltd. | M-phenoxyphenyl propionic acid derivatives and preparation thereof |
YU39566B (en) * | 1978-04-07 | 1984-12-31 | Lek Tovarna Farmacevtskih | Process of preparing 2-(3-benzoyl-phenyl)-propionic acid |
CA1195691A (en) * | 1980-01-28 | 1985-10-22 | Ikuo Ueda | Phenyl-alkanoic acid derivative and preparation thereof |
JPS57212137A (en) * | 1981-06-22 | 1982-12-27 | Fujisawa Pharmaceut Co Ltd | Preparation of phenyl aliphtic acid derivative |
SE8400239D0 (en) * | 1984-01-19 | 1984-01-19 | Pharmacia Ab | NEW ARYLETIC ACID DERIVATIVES |
US6160018A (en) * | 1995-03-13 | 2000-12-12 | Loma Linda University Medical Center | Prophylactic composition and method for alzheimer's Disease |
DE69832695T2 (en) * | 1997-03-10 | 2006-09-14 | Loma Linda University Medical Center, Loma Linda | USE OF R-ENANTIOMER NON-TEROIDAL INFLAMMATORY INHIBITION FOR THE PREVENTION OF ALZHEIMER'S DISEASE |
-
1999
- 1999-07-13 ES ES9901628A patent/ES2163986B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2163986A1 (en) | 2002-02-01 |
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