ES2163986B1 - ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II. - Google Patents

ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II.

Info

Publication number
ES2163986B1
ES2163986B1 ES9901628A ES9901628A ES2163986B1 ES 2163986 B1 ES2163986 B1 ES 2163986B1 ES 9901628 A ES9901628 A ES 9901628A ES 9901628 A ES9901628 A ES 9901628A ES 2163986 B1 ES2163986 B1 ES 2163986B1
Authority
ES
Spain
Prior art keywords
inhibitors
cyclooxygenase
compounds
present
cyclloxygenasa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9901628A
Other languages
Spanish (es)
Other versions
ES2163986A1 (en
Inventor
Casellas David Mauleon
Avellana Jaime Pascual
Perez Maria Luisa Garcia
Benet Albert Palomer
Calahorra Francisco Lopez
Via Josep Marti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES9901628A priority Critical patent/ES2163986B1/en
Publication of ES2163986A1 publication Critical patent/ES2163986A1/en
Application granted granted Critical
Publication of ES2163986B1 publication Critical patent/ES2163986B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

Ácidos {al}-arilpropiónicos y arilacéticos como inhibidores de la ciclooxigenasa-II. La presente invención se refiere a compuestos de fórmula general I, **FORMULA** inhibidores selectivos de la ciclooxigenasa-II, a sus sales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contienen. Los compuestos de la presente invención son útiles en el tratamiento de la inflamación, dolor y fiebre, así como de aquellas otras afecciones que recientemente se han asociado con las ciclooxigenasas, especialmente con la ciclooxigenasa-II, como, por ejemplo, el cáncer colorectal y la enfermedad de Alzheimer. De igual modo, la presente invención se refiere a un procedimiento para la preparación de los compuestos, así como a su utilización terapéutica.{Al} -arylpropionic and arylacetic acids as inhibitors of cyclooxygenase-II. The present invention relates to compounds of general formula I, ** FORMULA ** selective inhibitors of cyclooxygenase-II, their pharmaceutically acceptable salts and solvates, and the pharmaceutical compositions containing them. The compounds of the present invention are useful in the treatment of inflammation, pain and fever, as well as those other conditions that have recently been associated with cyclooxygenases, especially with cyclooxygenase-II, such as, for example, colorectal cancer and Alzheimer's disease. Similarly, the present invention relates to a process for the preparation of the compounds, as well as to their therapeutic use.

ES9901628A 1999-07-13 1999-07-13 ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II. Expired - Fee Related ES2163986B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9901628A ES2163986B1 (en) 1999-07-13 1999-07-13 ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9901628A ES2163986B1 (en) 1999-07-13 1999-07-13 ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II.

Publications (2)

Publication Number Publication Date
ES2163986A1 ES2163986A1 (en) 2002-02-01
ES2163986B1 true ES2163986B1 (en) 2003-02-16

Family

ID=8309292

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9901628A Expired - Fee Related ES2163986B1 (en) 1999-07-13 1999-07-13 ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II.

Country Status (1)

Country Link
ES (1) ES2163986B1 (en)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS183613B2 (en) * 1968-12-20 1978-07-31 Daniel Farge Method for producing derivatives of 3-benzoylphenyl acetic acid
GB1307284A (en) * 1970-03-16 1973-02-14 Boots Co Ltd 2-substituted phenyl propionic acids
OA04219A (en) * 1971-12-03 1979-12-31 Rhone Poulenc Sa Novel process for the preparation of (3-benzol-phenyl) -2 propionic acid and the like.
CA1041531A (en) * 1973-10-29 1978-10-31 Eisai Co. Ltd. M-phenoxyphenyl propionic acid derivatives and preparation thereof
YU39566B (en) * 1978-04-07 1984-12-31 Lek Tovarna Farmacevtskih Process of preparing 2-(3-benzoyl-phenyl)-propionic acid
CA1195691A (en) * 1980-01-28 1985-10-22 Ikuo Ueda Phenyl-alkanoic acid derivative and preparation thereof
JPS57212137A (en) * 1981-06-22 1982-12-27 Fujisawa Pharmaceut Co Ltd Preparation of phenyl aliphtic acid derivative
SE8400239D0 (en) * 1984-01-19 1984-01-19 Pharmacia Ab NEW ARYLETIC ACID DERIVATIVES
US6160018A (en) * 1995-03-13 2000-12-12 Loma Linda University Medical Center Prophylactic composition and method for alzheimer's Disease
DE69832695T2 (en) * 1997-03-10 2006-09-14 Loma Linda University Medical Center, Loma Linda USE OF R-ENANTIOMER NON-TEROIDAL INFLAMMATORY INHIBITION FOR THE PREVENTION OF ALZHEIMER'S DISEASE

Also Published As

Publication number Publication date
ES2163986A1 (en) 2002-02-01

Similar Documents

Publication Publication Date Title
AR029174A1 (en) DERIVATIVES OF ESPIROOXINDOL, PROCESS FOR PREPARATION, PHARMACEUTICAL FORMULATION, AND USE OF DERIVATIVES IN THE MANUFACTURE OF MEDICINES
AR029175A1 (en) 2-AMINO-PHENYLPURINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM, AND THE USE OF THEM FOR THE PREPARATION OF A MEDICINAL PRODUCT
AR037517A1 (en) DERIVATIVES OF NAFTIRIDINES, A PROCESS FOR THE PREPARATION, PHARMACEUTICAL COMPOSITION AND THE USE OF THEM FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF AN INFLAMMATORY DISEASE
AR021844A1 (en) ARIL-SUBSTITUTED PROPANOLAMINE DERIVATIVES, PROCEDURES FOR PREPARATION, MEDICATIONS CONTAINING THESE COMPOUNDS AND THEIR USE
AR003220A1 (en) ACILATED MELATONIN DERIVATIVES; PHARMACEUTICAL AND COSMETIC COMPOSITION AND THE USE OF THE SAME FOR THE PREPARATION OF A MEDICINAL PRODUCT.
DE69912606D1 (en) 2- (purin-9-yl) -tetrahydro-3,4-DIOL DERIVATIVES
PA8432901A1 (en) PIRIDILPIRROL COMPOUNDS
PA8442001A1 (en) DERIVATIVES OF CONDENSED BICYCLIC PIRIMIDINE
ES2167377T3 (en) DERIVATIVES OF PIRIDINA PHARMACOLOGICALLY ACTIVE AND PROCEDURES FOR THE PREPARATION OF THE SAME.
ES2186015T3 (en) DERIVATIVES OF 2- (PURIN-9-IL) -TETRAHIDROFURAN-3,4-DIOL.
CO5180642A1 (en) PIPERIDINE REPLACED COMPOUNDS, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE
CY1107391T1 (en) ARYL-FUSED AZAPOLYCYCLIC COMPOUNDS
BG104729A (en) 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
ES2077199T3 (en) NEW PIPERACINES 1,4-DISSTITUTED, ITS PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
AR029383A1 (en) SMALL MOLECULES, THE INTERMEDIARIES FOR THEIR SYNTHESIS, THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE TO PREPARE A MEDICINAL PRODUCT INTENDED FOR TREATMENT OR PROPHYLAXIS OF INFLAMMATORY DISEASES OR MEDIATIONED BY IMMUNE CELLS
AR020662A1 (en) POLYCYCLIC DIHYDROTIAZOL COMPOUNDS, PROCEDURES FOR THE PREPARATION, MEDICATION, PROCEDURE FOR THE PREPARATION OF SUCH MEDICINAL PRODUCT AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF A MEDICINAL PRODUCT.
AR003427A1 (en) PEPTIDES RELATED TO DOLASTATIN, PROCEDURE FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE USE OF THE SAME FOR THE PREPARATION OF SUCH PHARMACEUTICAL COMPOSITIONS.
AR019853A1 (en) DERIVED FROM THE 3-ARIL-2-HYDROXIPROPIONIC ACID, PROCESS AND INTERMEDIARY FOR THEIR PREPARATION, PHARMACEUTICAL FORMULATIONS, USE OF SUCH COMPOUND IN THE PREPARATION OF A MEDICINAL PRODUCT, METHOD FOR THE PROPHYLAXIS AND / OR TREATMENT OF CLINIC ASSOCIATED RESISTANCES AND FORMULATION
HUP0402422A2 (en) Deuterated substituted pyrazolylbenzylsulfonamides pharmaceutical compositions containing them and use thereof
SE9900961D0 (en) Novel compounds
PA8485601A1 (en) AZALIDAS OF 13 MEMBERS AND THEIR USE AS ANTIBIOTIC AGENTS.
AR021843A1 (en) DERIVATIVES OF PROPANOLAMINE SUBSTITUTED WITH HETEROCICLES, PROCEDURE FOR THEIR PREPARATION, AND ITS USE.
AR025046A1 (en) IL-5 NON-STEROID INHIBITORS, PROCEDURES AND INTERMEDIARIES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE SUCH INHIBITORS
UY28535A1 (en) DERIVATIVES OF BENCIMIDAZOL, COMPOSITIONS THAT CONTAIN THEM, PREPARATION AND USES OF THE SAME.
ECSP056190A (en) USEFUL COMPOUNDS IN ALZHEIMER'S DISEASE THERAPY AND FORMULATIONS CONTAINING THEM

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20020201

Kind code of ref document: A1

Effective date: 20020201

FG2A Definitive protection

Ref document number: 2163986B1

Country of ref document: ES

FD1A Patent lapsed

Effective date: 20100312