MX9302549A - Proteina receptora especifica para la region csvt cg de la trombospondina y metodo para su purificacion y caracterizacion. - Google Patents

Proteina receptora especifica para la region csvt cg de la trombospondina y metodo para su purificacion y caracterizacion.

Info

Publication number
MX9302549A
MX9302549A MX9302549A MX9302549A MX9302549A MX 9302549 A MX9302549 A MX 9302549A MX 9302549 A MX9302549 A MX 9302549A MX 9302549 A MX9302549 A MX 9302549A MX 9302549 A MX9302549 A MX 9302549A
Authority
MX
Mexico
Prior art keywords
thrombospondin
purification
region
csvt
characterization
Prior art date
Application number
MX9302549A
Other languages
English (en)
Inventor
George Paul Tuszynski
Jacob Eyal
Bruce King Hamilton
Original Assignee
W R Grace & Co Conn Y
Pennsylvania Med College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by W R Grace & Co Conn Y, Pennsylvania Med College filed Critical W R Grace & Co Conn Y
Publication of MX9302549A publication Critical patent/MX9302549A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona un receptor de matriz celular específico para la región CSVTCG de la trombospondina. También proporciona los métodos de purificación, clonación y expresión. Los anticuerpos dirigidos contra la proteína receptora son útiles en numerosas áreas de diagnóstico, profilácticas y terapéuticas.
MX9302549A 1992-05-14 1993-04-30 Proteina receptora especifica para la region csvt cg de la trombospondina y metodo para su purificacion y caracterizacion. MX9302549A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/883,659 US5367059A (en) 1992-05-14 1992-05-14 Cys-Ser-Val-Thr-Cys-Gly specific tumor cell adhesion receptor

Publications (1)

Publication Number Publication Date
MX9302549A true MX9302549A (es) 1994-07-29

Family

ID=25383057

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9302549A MX9302549A (es) 1992-05-14 1993-04-30 Proteina receptora especifica para la region csvt cg de la trombospondina y metodo para su purificacion y caracterizacion.

Country Status (5)

Country Link
US (1) US5367059A (es)
EP (1) EP0578342A3 (es)
JP (1) JPH07138296A (es)
CA (1) CA2095404A1 (es)
MX (1) MX9302549A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627265A (en) * 1993-03-05 1997-05-06 Washington University Receptor for cell-binding domain of thrombospondins
EP0730466A4 (en) * 1993-09-10 1999-04-14 Univ New York COMPOSITIONS AND METHOD FOR INHIBITING THE INVASION OF HEPATOCYTES BY MALARIASPOROZOITES
GB9509957D0 (en) * 1995-05-17 1995-07-12 Khalil Nasreen Post-translational activation of tgf-›1 involving the tsp-1 receptor cd36
US6716963B1 (en) 1998-05-22 2004-04-06 Abbott Laboratories Peptide antiangiogenic drugs
WO2000078359A2 (en) * 1999-06-21 2000-12-28 George Tuszynski Compositions for treating chemotherapy-resistant tumor cells
US6380161B1 (en) 1999-06-21 2002-04-30 Inkine Pharmaceutical Company, Inc. Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions
AU5627000A (en) * 1999-06-21 2001-02-05 Inkine Pharmaceutical Company, Inc. Angiocidin: a CYS-SER-VAL-THR-CYS-GLY specific tumor cell adhesion receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192744A (en) * 1990-01-12 1993-03-09 Northwestern University Method of inhibiting angiogenesis of tumors
US5190920A (en) * 1990-09-24 1993-03-02 W. R. Grace & Co.-Conn. Method for using synthetic analogs of thrombospondin for inhibiting metastasis activity
AU2795892A (en) * 1991-10-03 1993-05-03 Center For Blood Research, The Cd36 immunoadhesins and their use in selectively killing (plasmodium falciparum) infected erythrocytes
CA2134655A1 (en) * 1992-04-30 1993-11-11 Russell J. Howard Modulation of thrombospondin-cd36 interactions

Also Published As

Publication number Publication date
CA2095404A1 (en) 1993-11-15
US5367059A (en) 1994-11-22
EP0578342A3 (en) 1994-06-29
JPH07138296A (ja) 1995-05-30
EP0578342A2 (en) 1994-01-12

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