MX9206294A - Inhibidores de proteasa de vih - Google Patents

Inhibidores de proteasa de vih

Info

Publication number
MX9206294A
MX9206294A MX9206294A MX9206294A MX9206294A MX 9206294 A MX9206294 A MX 9206294A MX 9206294 A MX9206294 A MX 9206294A MX 9206294 A MX9206294 A MX 9206294A MX 9206294 A MX9206294 A MX 9206294A
Authority
MX
Mexico
Prior art keywords
protease inhibitors
hiv protease
formula
hiv
isoster
Prior art date
Application number
MX9206294A
Other languages
English (en)
Inventor
John Gerald Gleason
Robert Thomas Lum
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MX9206294A publication Critical patent/MX9206294A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de la fórmula I (ver fórmula I) en donde R1 y A son grupos terminales amino; Z es O o N-R2, M es un isoestero de dipéptido; y D1 y D2 están opcionalmente ausentes o son aminoácidos y sales farmacéuticamente aceptables de los mismos; son potentes inhibidores de la proteasa de VIH-1 y son útiles en el tratamiento de enfermedades virales tales como el Síndrome de Inmunodeficiencia Adquirida (SIDA).
MX9206294A 1991-11-01 1992-10-30 Inhibidores de proteasa de vih MX9206294A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78643591A 1991-11-01 1991-11-01

Publications (1)

Publication Number Publication Date
MX9206294A true MX9206294A (es) 1993-08-01

Family

ID=25138568

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9206294A MX9206294A (es) 1991-11-01 1992-10-30 Inhibidores de proteasa de vih

Country Status (7)

Country Link
EP (1) EP0610431A1 (es)
JP (1) JPH07501056A (es)
AU (1) AU3069192A (es)
MX (1) MX9206294A (es)
PT (1) PT101026A (es)
WO (1) WO1993009132A1 (es)
ZA (1) ZA928396B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430150A (en) * 1992-12-16 1995-07-04 American Cyanamid Company Retroviral protease inhibitors
US5455351A (en) * 1993-12-13 1995-10-03 Abbott Laboratories Retroviral protease inhibiting piperazine compounds
AUPM623994A0 (en) * 1994-06-15 1994-07-07 Biomolecular Research Institute Limited Antiviral dendrimers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3809145A1 (de) * 1988-03-18 1989-09-28 Merck Patent Gmbh Aminosaeurederivate
DE3812328A1 (de) * 1988-04-14 1989-10-26 Merck Patent Gmbh Aminosaeurederivate
IL91307A0 (en) * 1988-08-24 1990-03-19 Merck & Co Inc Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them

Also Published As

Publication number Publication date
ZA928396B (en) 1993-05-12
EP0610431A1 (en) 1994-08-17
WO1993009132A1 (en) 1993-05-13
JPH07501056A (ja) 1995-02-02
PT101026A (pt) 1994-05-31
AU3069192A (en) 1993-06-07

Similar Documents

Publication Publication Date Title
NO893400D0 (no) Hiv protease inhibitorer egnet for behandling av aids.
FI883739A0 (fi) Menetelmä terapeuttisesti aktiivisten fenoksi-indaanimetyyliamiinijohdannaisten valmistamiseksi
CY1107626T1 (el) Παραγωγα πυραζολιου για την θεραπεια του hiv
NO974899L (no) Analogifremgangsmåte for fremstilling av en terapeutisk aktiv aprotinin-analog
DK0951474T3 (da) Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf
MX9403380A (es) Inhibidores de proteasa de vih utiles para el tratamiento de sida.
NO911854D0 (no) Fremgangsmaate for fremstilling av peptid-derivater.
DK0528312T3 (da) Cykliske peptider og anvendelse deraf
NO905428D0 (no) Fremgangsmaate for fremstilling av hiv-proteaseinhibitorerfor behandling av aids.
NO170585C (no) Fremgangsmaate for fremstilling av difluorketonpeptidderivater
DK524788D0 (da) Anvendelse af morphin-antagonister til fremstilling af laegemidler med immunomodulerende og antiviral effekt, isaer til behandling af erhvervede immundefekt-tilstande
LV11985A (lv) Noteiktu cistina atvasinajumu farmakologiska izmantosana
ATE157988T1 (de) Neuartige prolyl-endopeptidase-inhibitoren sna- 115 und sna-115t, ihre herstellung, und hierbei verwendete stämme
DE68917837T2 (de) Peptid-Verbindungen.
MX9206294A (es) Inhibidores de proteasa de vih
MX9302327A (es) Aminoacidos ciclicos novedosos y derivados de los mismos.
DK482185D0 (da) Peptider, deres fremstilling og anvendelse som laegemidler
HK1040237A1 (en) Fused polycyclic amino acids as pharmaceutical agents.
AP2002002584A0 (en) Protease Inhibitors And Thier Pharmaceutical Uses.
ES2118131T3 (es) Polipeptidos derivados de la proteina endonucleasa del virus de la inmunodeficiencia adquirida humana.
ATE80553T1 (de) Behandlung von viraler infektion.
ES2095899T3 (es) Peptidos de la proteina gag de vih, su preparacion y uso.
ES2071038T3 (es) Peptidos asociados al hiv.
ES2065951T3 (es) Uso de un inhibidor de prolilendopeptidasa para el tratamiento del sida.
FI972389A (fi) Uusi menetelmä ranitidiinin valmistamiseksi