MX9206114A - Derivados de urea y proceso para su preparacion - Google Patents

Derivados de urea y proceso para su preparacion

Info

Publication number
MX9206114A
MX9206114A MX9206114A MX9206114A MX9206114A MX 9206114 A MX9206114 A MX 9206114A MX 9206114 A MX9206114 A MX 9206114A MX 9206114 A MX9206114 A MX 9206114A MX 9206114 A MX9206114 A MX 9206114A
Authority
MX
Mexico
Prior art keywords
carbon atoms
urea
derivatives
preparation
cycloalkyl
Prior art date
Application number
MX9206114A
Other languages
English (en)
Inventor
Robin Arthur Ellis Carr
Martin Pass
Pritom Shah
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919122591A external-priority patent/GB9122591D0/en
Priority claimed from GB919122540A external-priority patent/GB9122540D0/en
Priority claimed from GB919122551A external-priority patent/GB9122551D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MX9206114A publication Critical patent/MX9206114A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invención describe compuestos de fórmula general (I) en donde R1 representa un grupo seleccionado de CH2CONR4R5, XYR6, fenilo, cicloalquilo de 3 a 7 átomos de carbono o alquilo de 1 a 6 átomos de carbono, substituido opcionalmente por un grupo hidroxi, fenilo, alcoxicarbonilo de 1 a 6 átomos de carbono, cicloalquilo de 3 a 7 átomos de carbono, o adamantilo.
MX9206114A 1991-10-24 1992-10-23 Derivados de urea y proceso para su preparacion MX9206114A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919122591A GB9122591D0 (en) 1991-10-24 1991-10-24 Chemical compounds
GB919122540A GB9122540D0 (en) 1991-10-24 1991-10-24 Chemical compounds
GB919122551A GB9122551D0 (en) 1991-10-24 1991-10-24 Chemical compounds

Publications (1)

Publication Number Publication Date
MX9206114A true MX9206114A (es) 1993-08-01

Family

ID=27265902

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9206114A MX9206114A (es) 1991-10-24 1992-10-23 Derivados de urea y proceso para su preparacion

Country Status (5)

Country Link
EP (1) EP0538945A1 (es)
AU (1) AU2759692A (es)
IL (1) IL103529A0 (es)
MX (1) MX9206114A (es)
WO (1) WO1993008175A1 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
GB9316722D0 (en) * 1993-08-12 1993-09-29 Black James Foundation Bicyclo (2.2.2)octane derivatives
GB2264492B (en) * 1992-02-27 1996-09-25 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
RU94046297A (ru) * 1992-06-24 1996-11-27 Яманоути Фармасьютикал Ко. Новое бензодиазепиновое производное, способ его получения фармкомпозиция
GB9308431D0 (en) * 1993-04-23 1993-06-09 Glaxo Spa Chemical compounds
GB2282595A (en) * 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
GB2282594A (en) * 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
WO1996005827A1 (en) * 1994-08-18 1996-02-29 Merck & Co., Inc. N-2,3-dihydro-1-(2-propyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines
US5426185A (en) * 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5438055A (en) * 1993-11-22 1995-08-01 Merck & Co., Inc. Antiarrhythmic benzodiazepines
EP0730581B1 (en) * 1993-11-22 2001-10-04 Merck & Co. Inc. 3-acylaminobenzazepines
US5428157A (en) * 1993-11-22 1995-06-27 Merck & Co., Inc. 3-acylaminobenzodiazepines
EP0755394A1 (en) * 1994-04-15 1997-01-29 Glaxo Wellcome Inc. A method of inducing cholecystokinin agonist activity using 1,4-benzodiazepine compounds
HU220635B1 (hu) * 1994-08-18 2002-03-28 Merck & Co. Inc. 2,3-Dihidro-1-(2,2,2-trifluor-etil)-2-oxo-5-fenil-1H-1,4-benzodiazepin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
WO1996040656A1 (en) * 1995-06-07 1996-12-19 Merck & Co., Inc. Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3yl)-3-amides
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
WO1998000406A1 (en) * 1996-07-02 1998-01-08 Merck & Co., Inc. Method for the treatment of preterm labor
US5929071A (en) * 1996-07-02 1999-07-27 Merck & Co., Inc. Method for the treatment of preterm labor
FR2782997A1 (fr) * 1998-09-08 2000-03-10 Hoechst Marion Roussel Inc Nouveaux derives de la benzodiazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicaments et compositions pharmaceutiques les renfermant
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives
RS63653B1 (sr) 2015-07-22 2022-11-30 Enanta Pharm Inc Benzodiazepinski derivati kao inhibitori rsv
GB201513979D0 (en) * 2015-08-07 2015-09-23 Trio Medicines Ltd Synthesis of benzodiazepine derivatives
EP3402799B1 (en) 2016-01-15 2022-05-04 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
EP3582784B1 (en) 2017-02-16 2022-06-08 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
US10752598B2 (en) 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
EP3687543B1 (en) 2017-09-29 2024-03-20 Enanta Pharmaceuticals, Inc. Combinations of pharmaceutical agents as rsv inhibitors
CN111343990B (zh) 2017-11-13 2023-08-04 英安塔制药有限公司 苯并二氮杂䓬-2-酮和苯并氮杂䓬-2-酮衍生物的拆分方法
US10647711B2 (en) 2017-11-13 2020-05-12 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as RSV inhibitors
WO2019199908A1 (en) 2018-04-11 2019-10-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
CA3133300A1 (en) 2019-03-18 2020-09-24 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as rsv inhibitors
WO2020210246A1 (en) 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Heterocyclic compounds as rsv inhibitors
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
WO2021066922A1 (en) 2019-10-04 2021-04-08 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2032226A1 (en) * 1989-12-18 1991-06-19 Mark G. Bock Benzodiazepine analogs
IL96613A0 (en) * 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
AU656754B2 (en) * 1990-12-25 1995-02-16 Yamanouchi Pharmaceutical Co., Ltd. Novel benzodiazepine derivative
IL101514A (en) * 1991-04-10 1996-01-31 Merck & Co Inc History of benzodiazepines and anticoagulants containing cholecystokinin containing them
US5218115A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists

Also Published As

Publication number Publication date
AU2759692A (en) 1993-05-21
EP0538945A1 (en) 1993-04-28
WO1993008175A1 (en) 1993-04-29
IL103529A0 (en) 1993-03-15

Similar Documents

Publication Publication Date Title
MX9206114A (es) Derivados de urea y proceso para su preparacion
SE8804609D0 (sv) Adenosine derivatives
LV10608A (lv) N-acetonilbenzamidi un to pielietojums par fungicidiem
NO992549L (no) Sukkerforbindelse, geleringsmiddel og fremgangsmåte for fremstilling derav
MX9200817A (es) Derivados de piranil cianoguanidina y proceso para su preparacion.
UA27220C2 (uk) Спосіб одержання похідних 1-фенілімідазолін-2,5-діону
ES2063852T3 (es) Supresion de la sintesis y secrecion de la hormona paratiroide con derivados de vitamina d3.
MX9300875A (es) Procedimiento para la preparacion de compuestos azabiciclicos.
PT947504E (pt) Derivados de vitamina d 16-eno
DK0600950T3 (da) Tetrazolamider som inhibitorer af ACAT
SE9001269L (sv) 2-substituerade n,n'-ditrimetoxbensoylpiperaziner, en framstaellningsmetod foer dessa samt terapeutiska kompositioner som innehaaller dem
SE7903687L (sv) Cyklohexylkarboxylsyraderivat och sett att framstella desamma
ATE157968T1 (de) 4-methyl-3-phenyl-2-oxo-3-pyrrolinderivate, verfahren zu ihrer herstellung und diese enthaltende herbizide
ES2061564T3 (es) Nuevo procedimiento para la preparacion de derivados de 6,7-diacil-7-desacetilforscolina.
MX9304249A (es) Derivados de n-acildihidroquinolina, metodo para su produccion y composiciones herbicidas que los contienen.
BR9006967A (pt) Derivados de sulfamidos sulfonilureia e herbicidas
MY106898A (en) Aromatic compounds, their production processes and their compositions for the control of insect pests
DE59003834D1 (de) 1-Halogenvinyl-azole und diese enthaltende Fungizide und Wachstumsregulatoren.
EA199800931A1 (ru) Способ получения ингибиторов фосфодиэстеразы iv
ES2061864T3 (es) Sustancia antitumoral, procedimiento para su preparacion, y agente anticanceroso que la contiene.
DE69017763D1 (de) Angolamycin-Derivate.
YU90192A (sh) LANOSTA-7,9-DIEN-3β, 32-DIOL I POSTUPAK ZA NJEGOVO DOBIJANJE,9-DIEN-3BETA, 32-DIOL I POSTUPAK ZA NJEGOVU SINTEZU