MX393754B - Metodos y composiciones para inhibir cnksr1 - Google Patents
Metodos y composiciones para inhibir cnksr1Info
- Publication number
- MX393754B MX393754B MX2019015648A MX2019015648A MX393754B MX 393754 B MX393754 B MX 393754B MX 2019015648 A MX2019015648 A MX 2019015648A MX 2019015648 A MX2019015648 A MX 2019015648A MX 393754 B MX393754 B MX 393754B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compositions
- cnksr1
- inhibiting
- inhibiting cnksr1
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 102100040450 Connector enhancer of kinase suppressor of ras 1 Human genes 0.000 abstract 2
- 101000749825 Homo sapiens Connector enhancer of kinase suppressor of ras 1 Proteins 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261737658P | 2012-12-14 | 2012-12-14 | |
| PCT/US2013/075505 WO2014093988A2 (en) | 2012-12-14 | 2013-12-16 | Methods and compositions for inhibiting cnksr1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX393754B true MX393754B (es) | 2025-03-24 |
Family
ID=50935099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019015648A MX393754B (es) | 2012-12-14 | 2013-12-16 | Metodos y composiciones para inhibir cnksr1 |
| MX2015007608A MX372739B (es) | 2012-12-14 | 2013-12-16 | Metodos y composiciones para inhibir cnksr1. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015007608A MX372739B (es) | 2012-12-14 | 2013-12-16 | Metodos y composiciones para inhibir cnksr1. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9340532B2 (enExample) |
| EP (1) | EP2931280B1 (enExample) |
| JP (1) | JP6357292B2 (enExample) |
| AU (1) | AU2013358876B2 (enExample) |
| CA (1) | CA2895162C (enExample) |
| MX (2) | MX393754B (enExample) |
| WO (1) | WO2014093988A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2895162C (en) | 2012-12-14 | 2021-03-09 | D. Lynn Kirkpatrick | Methods and compositions for inhibiting cnksr1 |
| US10227356B2 (en) | 2015-04-20 | 2019-03-12 | Phusis Therapeutics, Inc. | Compounds, compositions and methods for inhibiting CNKSR1 |
| WO2018125983A1 (en) | 2016-12-30 | 2018-07-05 | Mitobridge, Inc. | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (acmsd) inhibitors |
| CN110698411B (zh) * | 2018-07-09 | 2023-05-09 | 四川大学 | 一类4-(胺烷基)酞嗪-1-酮类化合物、其制备方法和用途 |
| US20230312482A1 (en) * | 2020-07-28 | 2023-10-05 | Mirati Therapeutics, Inc. | Sos1 inhibitors |
| WO2022187804A1 (en) * | 2021-03-02 | 2022-09-09 | Icahn School Of Medicine At Mount Sinai | Benzoxazolone inhibitors of inflammasomes |
| WO2024192873A1 (zh) * | 2023-03-20 | 2024-09-26 | 杭州天玑济世生物科技有限公司 | 一类具有萘胺结构的小分子化合物的用途 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA775563A (en) | 1968-01-09 | Frank W. Horner Limited | Hypoglycemic thiadiazoles | |
| GB828963A (en) | 1956-08-03 | 1960-02-24 | Rhone Poulenc Sa | Pharmaceutical compositions containing 2-p-aminobenzenesulphonamido-5-t-butyl-1, 3, 4-thiadiazole |
| US3821222A (en) | 1971-11-22 | 1974-06-28 | Chevron Res | Hydrocarbyl sulfenylmercapto pyrimidines |
| US4017489A (en) | 1975-07-10 | 1977-04-12 | The Goodyear Tire & Rubber Company | Process of preparing unsymmetrical disulfides |
| DE2556011A1 (de) | 1975-12-12 | 1977-06-23 | Merck Patent Gmbh | Disulfide |
| IE47592B1 (en) * | 1977-12-29 | 1984-05-02 | Ici Ltd | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture |
| GB2152497B (en) | 1983-11-28 | 1987-08-05 | Otsuka Kagaku Kk | Process for the preparation of azetidinone derivatives |
| FR2573077B1 (fr) | 1984-11-13 | 1987-02-13 | Sanofi Sa | Nouveaux derives thiosulfonates, leur procede de preparation ainsi que les compositions pharmaceutiques les contenant |
| US4939140A (en) * | 1985-11-07 | 1990-07-03 | Pfizer Inc. | Heterocyclic oxophthalazinyl acetic acids |
| US4990523A (en) | 1989-06-19 | 1991-02-05 | A. H. Robins Company, Incorporated | Treatment of chronic inflammatory joint disease with arylsulfonamides |
| GB9507415D0 (en) * | 1994-06-08 | 1995-05-31 | Zylepsis Ltd | Production and uses of caffeic acid and derivatives thereof |
| US6139875A (en) | 1998-09-29 | 2000-10-31 | Eastman Chemical Company | Aqueous enteric coating composition and low gastric permeability enteric coating |
| FR2815032B1 (fr) | 2000-10-10 | 2003-08-08 | Pf Medicament | Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations |
| WO2002083064A2 (en) | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | A method of treating cancer |
| NZ531245A (en) * | 2001-08-15 | 2005-09-30 | Icos Corp | 2H-phthalazin-1-ones and methods for use thereof |
| GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| US20060142178A1 (en) | 2002-04-08 | 2006-06-29 | Barnett Stanley F | Method of treating cancer |
| GB0215823D0 (en) * | 2002-07-09 | 2002-08-14 | Astrazeneca Ab | Quinazoline derivatives |
| US20040102360A1 (en) | 2002-10-30 | 2004-05-27 | Barnett Stanley F. | Combination therapy |
| JP4787155B2 (ja) | 2003-06-24 | 2011-10-05 | イシス イノベーション リミテッド | タンパク質のジスルフィド結合形成およびグリコシル化の方法とそれに用いられる試薬 |
| BRPI0412380A (pt) | 2003-07-08 | 2006-09-19 | Novartis Ag | compostos de benzenossulfonilamino e composições farmacêuticas que contêm esses compostos |
| CA2559579A1 (en) | 2004-03-19 | 2005-09-29 | The Tapemark Company | Thermoplastic films and methods for making |
| JP2007530589A (ja) | 2004-03-26 | 2007-11-01 | アンフォラ ディスカバリー コーポレーション | 特定のトリアゾールを基礎とする化合物、組成物、およびそれらの使用 |
| SE0402635D0 (sv) | 2004-10-29 | 2004-10-29 | Astrazeneca Ab | Chemical compounds |
| DE102005011822A1 (de) * | 2005-03-15 | 2006-09-21 | Merck Patent Gmbh | Phthalazinone |
| ATE487706T1 (de) | 2005-10-06 | 2010-11-15 | Sanofi Aventis | Cyclische n-ä1,3,4ü-thiadiazol-2-yl- benzsulfonamide, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| WO2007106391A1 (en) | 2006-03-10 | 2007-09-20 | Lymphosign Inc. | Compounds for modulating cell proliferation, compositions and methods related thereto |
| KR20090017498A (ko) | 2006-04-04 | 2009-02-18 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | Ｐｉ３ 키나제 길항물질 |
| CA2674078C (en) | 2006-12-26 | 2012-03-20 | Femmepharma Holding Company, Inc. | Topical administration of danazol |
| CA2721371C (en) | 2008-04-14 | 2016-07-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of the pleckstrin homology domain and methods for using same |
| WO2010085968A1 (en) * | 2008-12-30 | 2010-08-05 | European Molecular Biology Laboratory (Embl) | Toluidine sulfonamides and their use as hif-inhibitors |
| CN102448951B (zh) * | 2009-04-06 | 2017-05-10 | 安吉奥斯医药品有限公司 | 丙酮酸激酶m2调节剂、治疗组合物和相关使用方法 |
| CA2773561A1 (en) | 2009-09-14 | 2011-03-17 | Phusis Therapeutics Inc. | Pharmaceutical compositions and formulations including inhibitors of the pleckstrin homology domain and methods for using same |
| KR20140027974A (ko) * | 2011-04-05 | 2014-03-07 | 버텍스 파마슈티칼스 인코포레이티드 | Ｔｒａ 키나제의 억제제로서 유용한 아미노피라진 화합물 |
| CA2895162C (en) | 2012-12-14 | 2021-03-09 | D. Lynn Kirkpatrick | Methods and compositions for inhibiting cnksr1 |
-
2013
- 2013-12-16 CA CA2895162A patent/CA2895162C/en active Active
- 2013-12-16 MX MX2019015648A patent/MX393754B/es unknown
- 2013-12-16 EP EP13863280.7A patent/EP2931280B1/en active Active
- 2013-12-16 JP JP2015548050A patent/JP6357292B2/ja active Active
- 2013-12-16 AU AU2013358876A patent/AU2013358876B2/en active Active
- 2013-12-16 MX MX2015007608A patent/MX372739B/es active IP Right Grant
- 2013-12-16 US US14/649,349 patent/US9340532B2/en active Active
- 2013-12-16 WO PCT/US2013/075505 patent/WO2014093988A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US9340532B2 (en) | 2016-05-17 |
| WO2014093988A2 (en) | 2014-06-19 |
| US20150307482A1 (en) | 2015-10-29 |
| JP2016508969A (ja) | 2016-03-24 |
| MX372739B (es) | 2020-05-06 |
| AU2013358876B2 (en) | 2018-05-10 |
| WO2014093988A3 (en) | 2014-08-07 |
| EP2931280B1 (en) | 2018-02-14 |
| CA2895162A1 (en) | 2014-06-19 |
| CA2895162C (en) | 2021-03-09 |
| AU2013358876A1 (en) | 2014-06-19 |
| MX2015007608A (es) | 2016-04-13 |
| EP2931280A2 (en) | 2015-10-21 |
| EP2931280A4 (en) | 2016-06-01 |
| JP6357292B2 (ja) | 2018-07-11 |
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