MX391445B - Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato. - Google Patents

Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.

Info

Publication number
MX391445B
MX391445B MX2018010998A MX2018010998A MX391445B MX 391445 B MX391445 B MX 391445B MX 2018010998 A MX2018010998 A MX 2018010998A MX 2018010998 A MX2018010998 A MX 2018010998A MX 391445 B MX391445 B MX 391445B
Authority
MX
Mexico
Prior art keywords
methyl
ylethynyl
pyridazin
methylpiperazin
imidazo
Prior art date
Application number
MX2018010998A
Other languages
English (en)
Spanish (es)
Inventor
Christopher K Murray
John J Chaber
Leonard W Rozamus
Pradeep Sharma
Original Assignee
Ariad Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50929140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX391445(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ariad Pharma Inc filed Critical Ariad Pharma Inc
Publication of MX391445B publication Critical patent/MX391445B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MX2018010998A 2012-12-12 2013-12-12 Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato. MX391445B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261736543P 2012-12-12 2012-12-12
US201261737007P 2012-12-13 2012-12-13
US201361788208P 2013-03-15 2013-03-15
PCT/US2013/074571 WO2014093579A2 (en) 2012-12-12 2013-12-12 Crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl)benzamide and its mono hydrochloride salt

Publications (1)

Publication Number Publication Date
MX391445B true MX391445B (es) 2025-03-21

Family

ID=50929140

Family Applications (11)

Application Number Title Priority Date Filing Date
MX2018010998A MX391445B (es) 2012-12-12 2013-12-12 Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2015007578A MX359147B (es) 2012-12-12 2013-12-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3-iletinil)-4-me til-n-(4-[ (4-metilpiperazin-1-il) metil]-3-(trifluorometil) fenil) benzamida y su sal de monoclorhidrato.
MX2021002255A MX2021002255A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002253A MX2021002253A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002264A MX2021002264A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002257A MX2021002257A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002254A MX2021002254A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002258A MX2021002258A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002256A MX2021002256A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002261A MX2021002261A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002259A MX2021002259A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.

Family Applications After (10)

Application Number Title Priority Date Filing Date
MX2015007578A MX359147B (es) 2012-12-12 2013-12-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3-iletinil)-4-me til-n-(4-[ (4-metilpiperazin-1-il) metil]-3-(trifluorometil) fenil) benzamida y su sal de monoclorhidrato.
MX2021002255A MX2021002255A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002253A MX2021002253A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002264A MX2021002264A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002257A MX2021002257A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002254A MX2021002254A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002258A MX2021002258A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002256A MX2021002256A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002261A MX2021002261A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002259A MX2021002259A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.

Country Status (9)

Country Link
US (9) US9493470B2 (OSRAM)
JP (4) JP6447508B2 (OSRAM)
CN (2) CN115043843A (OSRAM)
CA (3) CA3167093A1 (OSRAM)
CL (1) CL2015001643A1 (OSRAM)
HK (1) HK1218878A1 (OSRAM)
MX (11) MX391445B (OSRAM)
NZ (1) NZ709648A (OSRAM)
WO (2) WO2014093579A2 (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1973545B1 (en) 2005-12-23 2013-01-30 Ariad Pharmaceuticals, Inc. Bicyclic heteroaryl compounds
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
CA3167093A1 (en) 2012-12-12 2014-06-12 Ariad Pharmaceuticals, Inc. Crystalline form c of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
EP3016954B1 (en) * 2013-07-04 2018-10-31 Sandoz AG Crystalline forms of ponatinib hydrochloride
CN104496994B (zh) * 2014-01-06 2016-12-07 广东东阳光药业有限公司 一种炔类杂芳基化合物的新晶型
MA53150A (fr) * 2016-12-15 2021-05-26 Ariad Pharma Inc Composés de benzimidazole en tant qu'inhibiteurs de c-kit
US10221184B2 (en) 2017-01-20 2019-03-05 Apicore Us Llc Polymorphs of ponatinib hydrochloride
CA3067271A1 (en) * 2017-06-20 2018-12-27 Apotex Inc. Crystalline forms of ponatinib hydrochloride
CA3095869C (en) * 2018-04-02 2025-10-21 Stealth Biotherapeutics Corp Crystalline dipeptides useful in the synthesis of elamipretide
WO2019246479A1 (en) 2018-06-22 2019-12-26 Johnson Matthey Public Limited Company Form of ponatinib
BR112021008516A2 (pt) 2018-11-01 2021-09-14 Syros Pharmaceuticals, Inc. Inibidores de quinase 7 dependente de ciclina (cdk 7)
WO2020223235A1 (en) 2019-04-29 2020-11-05 Incyte Corporation Mini-tablet dosage forms of ponatinib
CN111004240B (zh) * 2019-12-13 2020-12-01 山东铂源药业有限公司 一种泊那替尼中间体3-乙炔基咪唑并[1,2-b]哒嗪的合成方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5099067A (en) 1988-08-05 1992-03-24 Northwestern University Use of ammonium formate as a hydrogen transfer reagent for reduction of chiral nitro compounds with retention of configuration
DE60020988T2 (de) 1999-11-08 2006-04-27 Schering Corp. Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperazin
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
DE10021246A1 (de) 2000-04-25 2001-10-31 Schering Ag Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel
IL159811A0 (en) 2001-07-13 2004-06-20 Neurogen Corp Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands
AR041992A1 (es) 2002-11-06 2005-06-08 Smithkline Beecham Corp Compuesto de piridinil benzoheterociclico, composicion farmaceutica que lo comprende y su uso para prepararla
GB0230089D0 (en) 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
BRPI0416935A (pt) 2003-11-28 2007-01-16 Novartis Ag derivados de diaril ureia no tratamento de doenças dependentes de quìnase de proteìna
EP1694691A1 (en) 2003-12-05 2006-08-30 Biovitrum Ab Improved synthesis of 2-substituted adenosines
JP2007517007A (ja) 2003-12-24 2007-06-28 アストラゼネカ アクチボラグ Ｔｉｅ２（ＴＥＫ）活性を持つピリミジン
ATE402705T1 (de) 2003-12-24 2008-08-15 Astrazeneca Ab Pyrimidine mit tie2 (tek) aktivität
US7947851B2 (en) 2004-04-07 2011-05-24 Merck Serono Sa 1,1′-(1,2-ethynediyl)bis-benzene derivatives as PTP 1-B inhibitors
EA200700243A1 (ru) 2004-07-14 2007-08-31 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы лечения гепатита с
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
GB0502418D0 (en) 2005-02-05 2005-03-16 Astrazeneca Ab Compounds
US20080194552A1 (en) 2005-03-31 2008-08-14 Astrazeneca Ab Aminopyrimidine Derivatives With Tie2 Inhibiting Activity
WO2007013673A1 (en) 2005-07-29 2007-02-01 Astellas Pharma Inc. Fused heterocycles as lck inhibitors
EP1940843A4 (en) 2005-08-11 2010-09-15 Ariad Pharma Inc UNSATURATED HETEROCYCLIC DERIVATIVES
CN101389338B (zh) * 2005-12-23 2013-06-26 阿里亚德医药股份有限公司 双环杂芳基化合物
EP1973545B1 (en) 2005-12-23 2013-01-30 Ariad Pharmaceuticals, Inc. Bicyclic heteroaryl compounds
JP5273038B2 (ja) 2006-05-08 2013-08-28 アリアド・ファーマシューティカルズ・インコーポレイテッド 単環式ヘテロアリール化合物
MX2008014289A (es) 2006-05-08 2008-11-26 Ariad Pharma Inc Compuestos heteroarilicos acetilenicos.
EP2107054A1 (en) 2008-04-01 2009-10-07 Università Degli Studi Di Milano - Bicocca Antiproliferative compounds and therapeutic uses thereof
US20100273772A1 (en) * 2009-04-23 2010-10-28 Wyeth Llc Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5)
US8329724B2 (en) * 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
US20120316137A1 (en) * 2009-10-30 2012-12-13 Ariad Pharmaceuticals, Inc. Methods and Compositions for Treating Cancer
KR20140022063A (ko) 2011-04-07 2014-02-21 어리어드 파마슈티칼스, 인코포레이티드 신경 변성 질환을 치료하기 위한 방법 및 조성물
EA201391486A1 (ru) 2011-04-07 2014-09-30 Ариад Фармасьютикалз, Инк. Способы и композиции для лечения болезни паркинсона
EP2841062A4 (en) 2012-04-25 2015-11-25 Ariad Pharma Inc METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATED BY RAF KINASE
CA3167093A1 (en) * 2012-12-12 2014-06-12 Ariad Pharmaceuticals, Inc. Crystalline form c of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride

Also Published As

Publication number Publication date
US20210340149A1 (en) 2021-11-04
MX2021002259A (es) 2021-05-27
CN115043843A (zh) 2022-09-13
US10662197B2 (en) 2020-05-26
CN105188701A (zh) 2015-12-23
JP2018168191A (ja) 2018-11-01
CL2015001643A1 (es) 2015-10-02
US20210277011A1 (en) 2021-09-09
US20170190707A1 (en) 2017-07-06
WO2014093583A2 (en) 2014-06-19
HK1218878A1 (zh) 2017-03-17
NZ709648A (en) 2020-05-29
US11192895B2 (en) 2021-12-07
JP2022037122A (ja) 2022-03-08
MX2021002255A (es) 2021-05-27
WO2014093579A3 (en) 2014-07-10
US10125136B2 (en) 2018-11-13
MX2021002253A (es) 2021-05-27
US11192896B2 (en) 2021-12-07
MX359147B (es) 2018-09-17
CA3022250A1 (en) 2014-06-12
US20210024527A1 (en) 2021-01-28
US20210277012A1 (en) 2021-09-09
CA2815506A1 (en) 2014-06-12
US9493470B2 (en) 2016-11-15
CA3167093A1 (en) 2014-06-12
US20150315194A1 (en) 2015-11-05
WO2014093579A2 (en) 2014-06-19
JP6447508B2 (ja) 2019-01-09
JP2016503010A (ja) 2016-02-01
JP7042175B2 (ja) 2022-03-25
MX2021002261A (es) 2021-05-27
JP7352841B2 (ja) 2023-09-29
US20240083902A1 (en) 2024-03-14
US11192897B2 (en) 2021-12-07
US20190169196A1 (en) 2019-06-06
MX2021002258A (es) 2021-05-27
CA2815506C (en) 2018-12-11
US20210277010A1 (en) 2021-09-09
JP2023179498A (ja) 2023-12-19
MX2021002256A (es) 2021-05-27
US11384086B2 (en) 2022-07-12
MX2021002254A (es) 2021-05-27
MX2021002257A (es) 2021-05-27
MX2021002264A (es) 2021-05-27
WO2014093583A3 (en) 2014-08-07
MX2015007578A (es) 2016-03-21
US11279705B2 (en) 2022-03-22

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