MX389993B - Determinación de modificaciones de bases de ácidos nucleicos - Google Patents

Determinación de modificaciones de bases de ácidos nucleicos

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Publication number
MX389993B
MX389993B MX2021000931A MX2021000931A MX389993B MX 389993 B MX389993 B MX 389993B MX 2021000931 A MX2021000931 A MX 2021000931A MX 2021000931 A MX2021000931 A MX 2021000931A MX 389993 B MX389993 B MX 389993B
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Mexico
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nucleic acid
bases
determination
modifications
modification
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MX2021000931A
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English (en)
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MX2021000931A (es
Inventor
Kwan Chee Chan
On Yee Tse
Peiyong Jiang
Rossa Wai Kwun Chiu
Suk Hang Cheng
Wenlei Peng
Yuk- Ming Dennis Lo
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Univ Hong Kong Chinese
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Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of MX2021000931A publication Critical patent/MX2021000931A/es
Publication of MX389993B publication Critical patent/MX389993B/es

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Abstract

La presente invención se refiere a sistemas y métodos para usar la determinación de la modificación de bases para analizar moléculas de ácido nucleico y adquirir datos para el análisis de moléculas de ácido nucleico. Las modificaciones de bases pueden incluir metilaciones. Los métodos para determinar las modificaciones de bases pueden incluir el uso de características derivadas de la secuenciación. Estas características pueden incluir el ancho del pulso de una señal óptica a partir de la secuenciación de bases, la duración entre pulsos de las bases y la identidad de las bases. Los modelos de aprendizaje automático pueden entrenarse para detectar las modificaciones de bases mediante el uso de estas características. Los niveles de modificación o metilación relativos entre haplotipos pueden indicar un trastorno. También pueden usarse estados de modificación o metilación para detectar moléculas quiméricas.
MX2021000931A 2019-08-16 2020-08-17 Determinación de modificaciones de bases de ácidos nucleicos MX389993B (es)

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Application Number Priority Date Filing Date Title
US201962887987P 2019-08-16 2019-08-16
US202062970586P 2020-02-05 2020-02-05
US202062991891P 2020-03-19 2020-03-19
US202063019790P 2020-05-04 2020-05-04
US202063051210P 2020-07-13 2020-07-13
PCT/CN2020/109602 WO2021032060A1 (en) 2019-08-16 2020-08-17 Determination of base modifications of nucleic acids

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MX2021000931A MX2021000931A (es) 2022-02-10
MX389993B true MX389993B (es) 2025-03-20

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MX2021000931A MX389993B (es) 2019-08-16 2020-08-17 Determinación de modificaciones de bases de ácidos nucleicos
MX2022001470A MX2022001470A (es) 2019-08-16 2021-01-22 Determinacion de modificaciones de bases de acidos nucleicos.
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EP (3) EP4357461A3 (es)
JP (4) JP7264534B2 (es)
KR (4) KR102658592B1 (es)
CN (5) CN116875669A (es)
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BR (1) BR122021009560B1 (es)
CA (1) CA3110884A1 (es)
DK (2) DK4365307T3 (es)
ES (2) ES3003866T3 (es)
GB (13) GB2590573B (es)
IL (3) IL294153B2 (es)
MX (3) MX389993B (es)
NZ (4) NZ784999A (es)
PH (1) PH12021550223A1 (es)
SG (1) SG11202101070QA (es)
TW (5) TWI783820B (es)
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CN112752853A (zh) 2021-05-04
AU2020323958B2 (en) 2022-02-03
NZ784999A (en) 2022-08-26
MX2022001469A (es) 2022-02-22
CN116855595A (zh) 2023-10-10
GB2590854B (en) 2022-03-30
NZ788335A (en) 2023-02-24
GB2608713B (en) 2023-09-06
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