MX388361B - Nebulizacion de inmunoglobulina. - Google Patents

Nebulizacion de inmunoglobulina.

Info

Publication number
MX388361B
MX388361B MX2016012022A MX2016012022A MX388361B MX 388361 B MX388361 B MX 388361B MX 2016012022 A MX2016012022 A MX 2016012022A MX 2016012022 A MX2016012022 A MX 2016012022A MX 388361 B MX388361 B MX 388361B
Authority
MX
Mexico
Prior art keywords
nebulization
immunoglobulin
aerosol
generating
composition
Prior art date
Application number
MX2016012022A
Other languages
English (en)
Other versions
MX2016012022A (es
Inventor
Cédric Pierre Vonarburg
Karin Steinführer
Ulrich Baumann
Original Assignee
Csl Behring Ag
Medizinische Hochschule Hannover
Pari Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Csl Behring Ag, Medizinische Hochschule Hannover, Pari Pharma Gmbh filed Critical Csl Behring Ag
Publication of MX2016012022A publication Critical patent/MX2016012022A/es
Publication of MX388361B publication Critical patent/MX388361B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
    • B05B17/0646—Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un método para generar un aerosol, caracterizado porque comprende las etapas de: (a) proporciona una composición acuosa líquida que comprende una inmunoglobulina policlonal (Ig), en donde la concentración de Ig se encuentra en el margen de 40 a 200 mg por mL; (b) proporcionar un nebulizador de membrana que tiene un depósito en el cual se llena la compasión; y (c) nebulizar la composición utilizando el nebulizador para obtener un aerosol, en donde la composición de inmunoglobulina tiene una viscosidad de 1 a 17 mPa s.
MX2016012022A 2014-04-03 2015-04-02 Nebulizacion de inmunoglobulina. MX388361B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14163399 2014-04-03
PCT/EP2015/057285 WO2015150510A1 (en) 2014-04-03 2015-04-02 Nebulization of immunoglobulin

Publications (2)

Publication Number Publication Date
MX2016012022A MX2016012022A (es) 2017-04-13
MX388361B true MX388361B (es) 2025-03-19

Family

ID=50397058

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012022A MX388361B (es) 2014-04-03 2015-04-02 Nebulizacion de inmunoglobulina.

Country Status (16)

Country Link
US (1) US11471617B2 (es)
EP (1) EP3125942B8 (es)
JP (2) JP7224092B2 (es)
KR (1) KR102337927B1 (es)
CN (2) CN106132398A (es)
AU (2) AU2015239145B2 (es)
CA (1) CA2943376C (es)
DK (1) DK3125942T3 (es)
ES (1) ES2902689T3 (es)
IL (1) IL247954B2 (es)
MX (1) MX388361B (es)
NZ (1) NZ725681A (es)
RU (1) RU2729546C2 (es)
SG (1) SG11201607688YA (es)
TW (1) TWI750108B (es)
WO (1) WO2015150510A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3048285B1 (fr) * 2016-02-25 2020-07-31 Hopitaux Paris Assist Publique Procede de nebulisation de proteines pour la generation de reactions immunochimiques, dispositif, utilisation
FR3064485A1 (fr) * 2017-03-31 2018-10-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Traitement d'une infection par le virus respiratoire syncytial
EP3818354B1 (en) * 2018-07-04 2024-05-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device and method for determining an aerosol delivery
EP3603617A1 (de) * 2018-07-30 2020-02-05 Sterna Biologicals GmbH & Co. KG Aerosolerzeugungseinrichtung zur inhalativen verabreichung einer antisense-molekül-haltigen zusammensetzung
MX2021006212A (es) * 2018-11-30 2021-08-11 Csl Behring Ag Metodos y composiciones para prevenir o tratar exacerbaciones agudas con inmunoglobulina policlonal.
EP4038194A1 (en) 2019-10-04 2022-08-10 Ultragenyx Pharmaceutical Inc. Methods for improved therapeutic use of recombinant aav
US20230034625A1 (en) * 2019-12-17 2023-02-02 Philip Morris Products S.A. Aerosol-forming substrate with nitrogen-containing nucleophilic compound
EP4249022A1 (en) * 2022-03-21 2023-09-27 PARI Pharma GmbH Drug-device combination
WO2025186423A1 (en) 2024-03-07 2025-09-12 Csl Behring Ag Immunoglobulin composition and method of generating an aerosol

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812854A (en) * 1972-10-20 1974-05-28 A Michaels Ultrasonic nebulizer
US4994269A (en) * 1989-03-17 1991-02-19 Miles Inc. Topical use of antibodies for prevention or treatment of pseudomonas infections
ES2129028T3 (es) 1990-07-19 1999-06-01 Us Commerce Procedimiento inmunoterapeutico mejorado para la prevencion o el tratamiento de las enfermedades virales de las vias respiratorias.
FR2708467B1 (fr) 1993-07-30 1995-10-20 Pasteur Merieux Serums Vacc Préparations d'immunoglobulines stabilisées et procédé pour leur préparation.
DE19953317C1 (de) 1999-11-05 2001-02-01 Pari Gmbh Inhalationsvernebler
US6585957B1 (en) 2000-01-25 2003-07-01 Aeropharm Technology Incorporated Medicinal aerosol formulation
MXPA02007187A (es) * 2000-01-25 2002-12-09 Aeropharm Technology Inc Fromulacion medicinal en aerosol.
DE10102846B4 (de) * 2001-01-23 2012-04-12 Pari Pharma Gmbh Aerosolgenerator
US6932967B2 (en) 2001-03-22 2005-08-23 Michael R. Simon Human medical treatment by aerosol inhalation of immunoglobulin A
EP1474196B1 (en) 2002-01-15 2016-08-17 Novartis AG Methods and systems for operating an aerosol generator
AU2003232081B2 (en) 2002-07-03 2009-02-05 Brandeis University Central airway administration for systemic delivery of therapeutics
US20050271660A1 (en) 2002-09-06 2005-12-08 Alexion Pharmaceuticals, Inc. Nebulization of monoclonal antibodies for treating pulmonary diseases
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US20050147664A1 (en) * 2003-11-13 2005-07-07 Elan Pharma International Ltd. Compositions comprising antibodies and methods of using the same for targeting nanoparticulate active agent delivery
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
DE102005038619A1 (de) 2005-08-16 2007-02-22 Pari GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments
EP1927373B1 (en) 2006-11-30 2012-08-22 PARI Pharma GmbH Inhalation nebulizer
US20080128527A1 (en) * 2006-12-05 2008-06-05 The Hong Kong Polytechnic University Liquid dispensing apparatus based on piezoelectrically driven hollow horn
JP5513130B2 (ja) 2007-02-23 2014-06-04 イェダ リサーチ アンド デベロップメント カンパニー リミテッド 金属タンパク質の活性を阻害するために有用な抗体および該抗体を含有する医薬組成物
EP2030644A1 (en) 2007-08-31 2009-03-04 PARI Pharma GmbH Aerosols for sinunasal drug delivery
US20100260853A1 (en) * 2007-12-13 2010-10-14 Amrik Basran Compositions for pulmonary delivery
US20120016818A1 (en) 2008-10-31 2012-01-19 Mark Hackett Classification of Biological Samples Using Spectroscopic Analysis
DE102008054431B3 (de) 2008-12-09 2010-06-17 Pari Pharma Gmbh Aerosoltherapievorrichtung
CA2743768A1 (en) 2008-12-10 2010-06-17 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Inhibition of inter-alpha trypsin inhibitor for the treatment of airway disease
CA2753645C (en) 2009-02-27 2016-07-26 Pari Pharma Gmbh Method for operating an aerosol inhalation device and aerosol inhalation device
DK2531218T3 (en) * 2010-02-04 2019-04-01 Csl Behring Ag immunoglobulin
ES2931330T3 (es) 2010-02-11 2022-12-28 Ablynx Nv Métodos y composiciones para la preparación de aerosoles
EP2380618A1 (en) 2010-04-26 2011-10-26 PARI Pharma GmbH Operating method for an aerosol delivery device and aerosol delivery device
LU91716B1 (en) * 2010-08-06 2012-02-07 Wurth Paul Sa Distribution chute
EP2457609A1 (en) * 2010-11-24 2012-05-30 PARI Pharma GmbH Aerosol generator
ES2832329T3 (es) * 2011-06-08 2021-06-10 Pari Pharma Gmbh Generador de aerosol
WO2013132052A1 (en) 2012-03-09 2013-09-12 Csl Behring Ag Compositions comprising secretory - like immunoglobulins

Also Published As

Publication number Publication date
CN115177588A (zh) 2022-10-14
NZ725681A (en) 2023-03-31
IL247954B1 (en) 2023-05-01
IL247954A0 (en) 2016-11-30
US11471617B2 (en) 2022-10-18
AU2015239145A1 (en) 2016-11-17
BR112016021296A8 (pt) 2021-07-20
CA2943376A1 (en) 2015-10-08
JP7256161B2 (ja) 2023-04-11
AU2019246787A1 (en) 2019-10-31
TWI750108B (zh) 2021-12-21
KR20160141832A (ko) 2016-12-09
CA2943376C (en) 2022-06-14
SG11201607688YA (en) 2016-10-28
AU2015239145B2 (en) 2019-07-11
JP2017511337A (ja) 2017-04-20
MX2016012022A (es) 2017-04-13
RU2016142612A (ru) 2018-05-03
ES2902689T3 (es) 2022-03-29
IL247954B2 (en) 2023-09-01
RU2016142612A3 (es) 2018-11-12
BR112016021296A2 (pt) 2017-08-15
KR102337927B1 (ko) 2021-12-14
CN106132398A (zh) 2016-11-16
JP2021050210A (ja) 2021-04-01
RU2729546C2 (ru) 2020-08-07
EP3125942A1 (en) 2017-02-08
US20170021114A1 (en) 2017-01-26
WO2015150510A1 (en) 2015-10-08
EP3125942B1 (en) 2021-10-13
JP7224092B2 (ja) 2023-02-17
DK3125942T3 (da) 2021-12-20
EP3125942B8 (en) 2021-12-01
TW201601755A (zh) 2016-01-16

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