MX364849B - Proceso para la preparacion de 5-fluorotriptofol. - Google Patents

Proceso para la preparacion de 5-fluorotriptofol.

Info

Publication number
MX364849B
MX364849B MX2016011007A MX2016011007A MX364849B MX 364849 B MX364849 B MX 364849B MX 2016011007 A MX2016011007 A MX 2016011007A MX 2016011007 A MX2016011007 A MX 2016011007A MX 364849 B MX364849 B MX 364849B
Authority
MX
Mexico
Prior art keywords
fluorotryptophol
preparation
pyrano
indol
spiro
Prior art date
Application number
MX2016011007A
Other languages
English (en)
Other versions
MX2016011007A (es
Inventor
Prühs Stefan
Schäfer Olaf
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2016011007A publication Critical patent/MX2016011007A/es
Publication of MX364849B publication Critical patent/MX364849B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se relaciona con un proceso para la preparación de 5-fluorotriptofol así como con un proceso para la preparación de (1r,4r)-6´-fluoro-N,N-dimetil-4-fenil-4´,9´-dihidro -3´H-spiro[ciclohexan-1,1´-piran-[3,4b]-indol]-4-amina utilizando el 5-fluorotriptofol obtenido mediante el primer proceso. El proceso de conformidad con la invención proporciona 5-fluorotriptofol en rendimiento y pureza mejorados sin la necesidad de purificación cromatográfica del producto.
MX2016011007A 2014-02-27 2015-02-26 Proceso para la preparacion de 5-fluorotriptofol. MX364849B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14000696 2014-02-27
PCT/EP2015/000441 WO2015128088A1 (en) 2014-02-27 2015-02-26 Process for the preparation of 5-fluorotryptophol

Publications (2)

Publication Number Publication Date
MX2016011007A MX2016011007A (es) 2016-10-28
MX364849B true MX364849B (es) 2019-05-09

Family

ID=50189481

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011007A MX364849B (es) 2014-02-27 2015-02-26 Proceso para la preparacion de 5-fluorotriptofol.

Country Status (11)

Country Link
US (1) US10323040B2 (es)
EP (1) EP3110797B1 (es)
CN (1) CN106255680B (es)
ES (1) ES2689447T3 (es)
HU (1) HUE040039T2 (es)
IL (1) IL247443B (es)
MX (1) MX364849B (es)
PL (1) PL3110797T3 (es)
PT (1) PT3110797T (es)
SI (1) SI3110797T1 (es)
WO (1) WO2015128088A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
WO2024173714A1 (en) 2023-02-15 2024-08-22 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200400963A (en) 2002-05-21 2004-01-16 Wyeth Corp R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US20060166947A1 (en) 2004-10-01 2006-07-27 Anderson Kenneth C Multiple myeloma treatments
DE102006019597A1 (de) 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033109A1 (de) 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
DE102007009235A1 (de) 2007-02-22 2008-09-18 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate

Also Published As

Publication number Publication date
CN106255680A (zh) 2016-12-21
WO2015128088A1 (en) 2015-09-03
ES2689447T3 (es) 2018-11-14
CN106255680B (zh) 2019-10-22
HUE040039T2 (hu) 2019-02-28
US20160362417A1 (en) 2016-12-15
PT3110797T (pt) 2018-10-29
IL247443B (en) 2019-03-31
MX2016011007A (es) 2016-10-28
US10323040B2 (en) 2019-06-18
SI3110797T1 (sl) 2018-11-30
EP3110797A1 (en) 2017-01-04
EP3110797B1 (en) 2018-08-29
PL3110797T3 (pl) 2019-11-29

Similar Documents

Publication Publication Date Title
ZA201802657B (en) Crystal forms of beta-nicotinamide mononucleotide
PH12015502839A1 (en) Antiviral compounds
WO2014178078A3 (en) Novel cloning, expression & purification method for the preparation of ranibizumab
EA201790916A1 (ru) Новые лиганды rig-i и способы их получения
EP3331825A4 (en) SILICA FOR METHOD FOR THE PRODUCTION OF HIGH-PURITY SILICON
MX2014002996A (es) Anticuerpos anti - egfr/anti - igf-1r bisespecificos.
AU2012283449A8 (en) Crystalline (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
WO2014057498A3 (en) Process for the preparation of cobicistat intermediates
MX2015006915A (es) Preparacion de una bebida estable.
WO2016105172A3 (en) A method for preparing gadobutrol
AU2013212209A8 (en) (1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof
MX2015012809A (es) Procedimiento para la elaboracion de gadofosveset trisodico monohidratado.
WO2015063795A3 (en) Novel process for preparation of optically pure norephedrine and its derivatives
IN2014KN02722A (es)
MY171770A (en) An apparatus for continuous separation of valine and a method for continuous separation of valine using the same
MX355303B (es) Compuestos novedosos.
MX2013013436A (es) Derivados de indol sustituidos para el tratamiento de transtornos inmunologicos.
PH12018500872A1 (en) Innovative preparation and crystallization of iosimenol
MX364849B (es) Proceso para la preparacion de 5-fluorotriptofol.
WO2014118606A3 (en) A novel process for the preparation of silodosin
WO2015087343A3 (en) An improved process for the preparation of nilotinib and pharmaceutically acceptable salts thereof
WO2014178064A3 (en) "an improved process for the preparation of fluvoxamine maleate"
WO2014102759A3 (en) Process for the preparation of dasatinib and its intermediates
MX353331B (es) Formas solidas de clorhidrato de (1r,4r)-6´-fluoro-n,n-dimetil-4-f enil-4´,9´-dihidro-3´h-espiro-[ciclohexano-1,1´-pirano[3,4,b]indo l]-4-amina.
SI2797925T1 (sl) Postopek za pripravo (1r,4r)-6'-fluoro(N,N-dimetil- in N-metil)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano-(3,4,b) indol)-4-amina

Legal Events

Date Code Title Description
FG Grant or registration