MX362991B - Prediccion de la toxicidad de productos farmaceuticos en el desarrollo humano utilizando celulas similares a celulas madre humanas y relaciones metabolomicas. - Google Patents
Prediccion de la toxicidad de productos farmaceuticos en el desarrollo humano utilizando celulas similares a celulas madre humanas y relaciones metabolomicas.Info
- Publication number
- MX362991B MX362991B MX2015005476A MX2015005476A MX362991B MX 362991 B MX362991 B MX 362991B MX 2015005476 A MX2015005476 A MX 2015005476A MX 2015005476 A MX2015005476 A MX 2015005476A MX 362991 B MX362991 B MX 362991B
- Authority
- MX
- Mexico
- Prior art keywords
- human
- developmental toxicity
- metabolomic
- pharmaceuticals
- ratios
- Prior art date
Links
- 231100000415 developmental toxicity Toxicity 0.000 title abstract 2
- 230000007673 developmental toxicity Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 238000002705 metabolomic analysis Methods 0.000 title 1
- 230000001431 metabolomic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 2
- 229960003067 cystine Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229960003104 ornithine Drugs 0.000 abstract 2
- 238000012360 testing method Methods 0.000 abstract 2
- 206010043275 Teratogenicity Diseases 0.000 abstract 1
- 239000000090 biomarker Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 231100000101 reproductive and developmental toxicity testing Toxicity 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 231100000211 teratogenicity Toxicity 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
- G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
- G01N23/225—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material using electron or ion
- G01N23/2255—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material using electron or ion using incident ion beams, e.g. proton beams
- G01N23/2258—Measuring secondary ion emission, e.g. secondary ion mass spectrometry [SIMS]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Developmental Biology & Embryology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261721746P | 2012-11-02 | 2012-11-02 | |
| US201361827407P | 2013-05-24 | 2013-05-24 | |
| PCT/US2013/067980 WO2014071137A1 (en) | 2012-11-02 | 2013-11-01 | Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomic ratios |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015005476A MX2015005476A (es) | 2015-10-29 |
| MX362991B true MX362991B (es) | 2019-03-01 |
Family
ID=50628081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015005476A MX362991B (es) | 2012-11-02 | 2013-11-01 | Prediccion de la toxicidad de productos farmaceuticos en el desarrollo humano utilizando celulas similares a celulas madre humanas y relaciones metabolomicas. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20150301025A1 (enExample) |
| EP (1) | EP2914748B1 (enExample) |
| JP (2) | JP6339581B2 (enExample) |
| CN (1) | CN104822843B (enExample) |
| CA (1) | CA2888064C (enExample) |
| DK (1) | DK2914748T3 (enExample) |
| HU (1) | HUE043604T2 (enExample) |
| MX (1) | MX362991B (enExample) |
| WO (1) | WO2014071137A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2016000293A (es) * | 2013-07-09 | 2016-06-21 | Stemina Biomarker Discovery Inc | Biomarcadores del trastrono del espectro autista. |
| FI126398B (en) | 2014-12-18 | 2016-11-15 | Upm Kymmene Corp | Method for chemical testing |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| CN109207551B (zh) * | 2017-07-07 | 2023-05-26 | 上海睿智化学研究有限公司 | 一种筛选叶酸代谢相关药物的方法 |
| WO2019173671A1 (en) * | 2018-03-09 | 2019-09-12 | Stemina Biomarker Discovery, Inc. | In vitro assay to predict cardiotoxicity |
| JP7791189B2 (ja) * | 2020-11-30 | 2025-12-23 | サノフイ | 用量－反応グラフの画像の分類 |
| CN119667130B (zh) * | 2025-02-13 | 2025-05-09 | 生态环境部华南环境科学研究所(生态环境部生态环境应急研究所) | 一种基于血清组氨酸/犬尿氨酸快速评估双酚类物质暴露毒性效应的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US7329489B2 (en) | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| JP2008540575A (ja) * | 2005-05-13 | 2008-11-20 | レキシコン・ファーマシューティカルズ・インコーポレーテッド | 多環系化合物とその使用の方法 |
| EP2013619B1 (en) | 2006-04-10 | 2017-10-11 | Wisconsin Alumni Research Foundation | Methods for using human embryonic stem cells to evaluate toxicity of pharmaceutical compounds & other chemicals |
| US8703424B2 (en) * | 2010-03-22 | 2014-04-22 | Stemina Biomarker Discovery, Inc. | Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics |
| WO2011143609A1 (en) * | 2010-05-14 | 2011-11-17 | Deseret Biologicals, Inc. | Formulations of diluted genetic material and methods for making same |
| US9447506B2 (en) | 2012-07-30 | 2016-09-20 | David Whitmore | Cathodic protection of a concrete structure |
-
2013
- 2013-11-01 EP EP13850210.9A patent/EP2914748B1/en active Active
- 2013-11-01 US US14/439,723 patent/US20150301025A1/en not_active Abandoned
- 2013-11-01 HU HUE13850210A patent/HUE043604T2/hu unknown
- 2013-11-01 MX MX2015005476A patent/MX362991B/es unknown
- 2013-11-01 CA CA2888064A patent/CA2888064C/en active Active
- 2013-11-01 CN CN201380057328.0A patent/CN104822843B/zh active Active
- 2013-11-01 WO PCT/US2013/067980 patent/WO2014071137A1/en not_active Ceased
- 2013-11-01 JP JP2015540802A patent/JP6339581B2/ja active Active
- 2013-11-01 DK DK13850210.9T patent/DK2914748T3/da active
-
2017
- 2017-12-20 US US15/848,188 patent/US10209240B2/en active Active
-
2018
- 2018-05-10 JP JP2018091559A patent/JP6581244B2/ja active Active
- 2018-12-18 US US16/224,150 patent/US20190128872A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK2914748T3 (da) | 2019-06-11 |
| EP2914748A1 (en) | 2015-09-09 |
| JP2018157823A (ja) | 2018-10-11 |
| CN104822843A (zh) | 2015-08-05 |
| JP6581244B2 (ja) | 2019-09-25 |
| US20150301025A1 (en) | 2015-10-22 |
| CA2888064C (en) | 2023-05-30 |
| US20180128814A1 (en) | 2018-05-10 |
| MX2015005476A (es) | 2015-10-29 |
| CN104822843B (zh) | 2020-01-21 |
| EP2914748B1 (en) | 2019-03-13 |
| JP2016501516A (ja) | 2016-01-21 |
| EP2914748A4 (en) | 2016-06-01 |
| US20190128872A1 (en) | 2019-05-02 |
| JP6339581B2 (ja) | 2018-06-06 |
| CA2888064A1 (en) | 2014-05-08 |
| US10209240B2 (en) | 2019-02-19 |
| WO2014071137A1 (en) | 2014-05-08 |
| HUE043604T2 (hu) | 2019-08-28 |
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