MX362129B - Modulacion del crecimiento de bifidobacterias mediante el uso de una combinacion de oligosacaridos que se encuentran en la leche humana. - Google Patents
Modulacion del crecimiento de bifidobacterias mediante el uso de una combinacion de oligosacaridos que se encuentran en la leche humana.Info
- Publication number
- MX362129B MX362129B MX2014008513A MX2014008513A MX362129B MX 362129 B MX362129 B MX 362129B MX 2014008513 A MX2014008513 A MX 2014008513A MX 2014008513 A MX2014008513 A MX 2014008513A MX 362129 B MX362129 B MX 362129B
- Authority
- MX
- Mexico
- Prior art keywords
- bifidobacteria
- growth
- modulation
- combination
- human milk
- Prior art date
Links
- 241000186000 Bifidobacterium Species 0.000 title abstract 2
- 210000004251 human milk Anatomy 0.000 title 1
- 235000020256 human milk Nutrition 0.000 title 1
- 229920001542 oligosaccharide Polymers 0.000 title 1
- 150000002482 oligosaccharides Chemical class 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- TYALNJQZQRNQNQ-UHFFFAOYSA-N #alpha;2,6-sialyllactose Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OCC1C(O)C(O)C(O)C(OC2C(C(O)C(O)OC2CO)O)O1 TYALNJQZQRNQNQ-UHFFFAOYSA-N 0.000 abstract 1
- CILYIEBUXJIHCO-UHFFFAOYSA-N 102778-91-6 Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OC1C(O)C(OC2C(C(O)C(O)OC2CO)O)OC(CO)C1O CILYIEBUXJIHCO-UHFFFAOYSA-N 0.000 abstract 1
- 229940062827 2'-fucosyllactose Drugs 0.000 abstract 1
- HWHQUWQCBPAQQH-UHFFFAOYSA-N 2-O-alpha-L-Fucosyl-lactose Natural products OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(CO)OC1OC(C(O)CO)C(O)C(O)C=O HWHQUWQCBPAQQH-UHFFFAOYSA-N 0.000 abstract 1
- HWHQUWQCBPAQQH-BWRPKUOHSA-N 2-fucosyllactose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O HWHQUWQCBPAQQH-BWRPKUOHSA-N 0.000 abstract 1
- DVGKRPYUFRZAQW-UHFFFAOYSA-N 3 prime Natural products CC(=O)NC1OC(CC(O)C1C(O)C(O)CO)(OC2C(O)C(CO)OC(OC3C(O)C(O)C(O)OC3CO)C2O)C(=O)O DVGKRPYUFRZAQW-UHFFFAOYSA-N 0.000 abstract 1
- CILYIEBUXJIHCO-UITFWXMXSA-N N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)O[C@@H]2CO)O)O[C@H](CO)[C@@H]1O CILYIEBUXJIHCO-UITFWXMXSA-N 0.000 abstract 1
- OIZGSVFYNBZVIK-UHFFFAOYSA-N N-acetylneuraminosyl-D-lactose Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1O OIZGSVFYNBZVIK-UHFFFAOYSA-N 0.000 abstract 1
- SNFSYLYCDAVZGP-UHFFFAOYSA-N UNPD26986 Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(OC(O)C(O)C2O)CO)OC(CO)C(O)C1O SNFSYLYCDAVZGP-UHFFFAOYSA-N 0.000 abstract 1
- TYALNJQZQRNQNQ-JLYOMPFMSA-N alpha-Neup5Ac-(2->6)-beta-D-Galp-(1->4)-beta-D-Glcp Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)O[C@@H]2CO)O)O1 TYALNJQZQRNQNQ-JLYOMPFMSA-N 0.000 abstract 1
- 235000013350 formula milk Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000013406 prebiotics Nutrition 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
La presente invención se refiere a una formulación líquida o seca de prebióticos para la administración oral a un humano, caracterizad porque comprende a) 0.5-2 mg/ml de 2´-fucosilactosa, 1-4 mg/ml de 3´-sialilactosa y 0.5-2 mg/ml de 6´-sialilactosa, cuando dicho formulación es líquida, o b) al menos 0.4% del peso de 6´-sialilactosa, cuando dicha formulación es un polvo seco.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161441451P | 2011-02-10 | 2011-02-10 | |
PCT/IB2012/050511 WO2012107865A2 (en) | 2011-02-10 | 2012-02-03 | Modulation of growth of bifidobacteria using a combination of oligosaccharides found in human milk |
Publications (1)
Publication Number | Publication Date |
---|---|
MX362129B true MX362129B (es) | 2019-01-07 |
Family
ID=45809349
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014008513A MX362129B (es) | 2011-02-10 | 2012-02-03 | Modulacion del crecimiento de bifidobacterias mediante el uso de una combinacion de oligosacaridos que se encuentran en la leche humana. |
MX2013009087A MX345413B (es) | 2011-02-10 | 2012-02-03 | Modulacion del crecimiento de bifidobacterias mediante el uso de una combinacion de oligosacaridos que se encuentran en la leche humana. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013009087A MX345413B (es) | 2011-02-10 | 2012-02-03 | Modulacion del crecimiento de bifidobacterias mediante el uso de una combinacion de oligosacaridos que se encuentran en la leche humana. |
Country Status (18)
Country | Link |
---|---|
US (3) | US20140371173A1 (es) |
EP (2) | EP2672844B2 (es) |
CN (2) | CN103347405A (es) |
AU (1) | AU2012215042B2 (es) |
BR (1) | BR112013020108A2 (es) |
CA (1) | CA2825697A1 (es) |
CL (1) | CL2013002210A1 (es) |
ES (2) | ES2692533T3 (es) |
IL (1) | IL227487A (es) |
MX (2) | MX362129B (es) |
MY (1) | MY161034A (es) |
PL (1) | PL2672844T3 (es) |
PT (1) | PT2672844E (es) |
RU (1) | RU2586928C2 (es) |
SG (1) | SG192095A1 (es) |
TW (1) | TW201244640A (es) |
WO (1) | WO2012107865A2 (es) |
ZA (1) | ZA201306751B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140371173A1 (en) | 2011-02-10 | 2014-12-18 | Nestec S.A. | Modulation of growth of bifidobacteria using a combination of oligosaccharides found in human milk |
WO2012177556A2 (en) | 2011-06-20 | 2012-12-27 | H.J. Heinz Company | Probiotic compositions and methods |
JP2015512936A (ja) * | 2012-04-13 | 2015-04-30 | トラスティーズ オブ ボストン カレッジ | プレバイオティクス組成物およびその使用方法 |
DK2708145T3 (en) | 2012-09-14 | 2016-07-18 | Abbott Lab | Nutritional Compositions for Use in Methods to Modulate Corticosterone Levels in Psychologically Stressed Individuals |
SG11201608248YA (en) | 2014-04-08 | 2016-10-28 | Abbott Lab | Methods for enhancing mucosal innate immune responses to and/or detection of pathogens using human milk oligosaccharides |
CN107249611A (zh) * | 2014-10-24 | 2017-10-13 | 进化生物系统股份有限公司 | 活化的双歧杆菌及其应用方法 |
EP3223826A1 (en) * | 2014-11-26 | 2017-10-04 | Abbott Laboratories | Infant formula with rrr-alpha-tocopherol, 2'-fucosyllactose, and a probiotic |
WO2016086157A1 (en) * | 2014-11-26 | 2016-06-02 | Abbott Laboratories | Infant formula comprising human milk oligosaccharides, polyunsaturated fatty acids, nucleotides, and lutein |
US10987368B2 (en) | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
CN107106584A (zh) | 2014-12-08 | 2017-08-29 | 格礼卡姆股份公司 | 用于治疗代谢障碍的合成组合物 |
US10881674B2 (en) | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
MX2017010923A (es) * | 2015-03-05 | 2018-01-16 | Nestec Sa | Composiciones para usar en el mejoramiento de la consistencia o la frecuencia de las heces en infantes o niños pequeños. |
ES2950489T3 (es) | 2015-10-28 | 2023-10-10 | Glycom As | Composición sintética y método para modular los trastornos de la emoción y del ánimo |
ES2927009T3 (es) | 2015-10-28 | 2022-10-31 | Glycom As | Composición sintética y método para modular la función cerebral y la conducta |
MY186217A (en) * | 2015-12-15 | 2021-06-30 | Nestle Sa | Mixture of hmos |
SG10202100843TA (en) * | 2016-07-28 | 2021-03-30 | Fonterra Cooperative Group Ltd | Dairy product and process |
WO2018237149A1 (en) * | 2017-06-21 | 2018-12-27 | Abbott Laboratories | METHODS FOR INCREASING THE GROWTH OF BENEFICIAL BACTERIA IN THE GASTROINTESTINAL TRACT |
US20220241354A1 (en) * | 2019-06-05 | 2022-08-04 | Morinaga Milk Industry Co., Ltd. | Composition |
JP7474596B2 (ja) * | 2020-01-20 | 2024-04-25 | 森永乳業株式会社 | 新規ビフィドバクテリウム属細菌、および当該細菌を含む組成物、並びに当該細菌の増殖促進用の組成物 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260280A (en) | 1989-02-07 | 1993-11-09 | Snow Brand Milk Products Co., Ltd. | Bacterial toxin neutralizer |
TWI265008B (en) | 2000-02-17 | 2006-11-01 | Wyeth Corp | Nutritional formulation comprising oligofructose and sialyllactose |
US20010034477A1 (en) * | 2000-02-18 | 2001-10-25 | James Mansfield | Multivariate analysis of green to ultraviolet spectra of cell and tissue samples |
US6913778B2 (en) | 2001-12-21 | 2005-07-05 | Wyeth | Infant formula compositions comprising increased amounts of alpha-lactalbumin |
US7867541B2 (en) * | 2003-04-14 | 2011-01-11 | Mead Johnson Nutrition Company | Compositions and methods of formulation for enteral formulas containing sialic acid |
CN1863463B (zh) | 2003-06-23 | 2011-05-04 | 雀巢技术公司 | 用于促进肠道屏障成熟的营养组合物 |
CA2548140A1 (en) † | 2003-12-05 | 2005-06-23 | University Of Massachusetts | Oligosaccharide compositions and use thereof in the treatment of infection |
WO2007051475A1 (en) | 2005-11-04 | 2007-05-10 | Arla Foods Amba | A concentrate derived from a milk product enriched in naturally occurring sialyllactose and a process for preparation thereof |
WO2007114683A1 (en) * | 2006-03-30 | 2007-10-11 | N.V. Nutricia | Milk oligosaccharides for stimulating the immune system |
EP2060257A1 (en) * | 2007-11-08 | 2009-05-20 | Nestec S.A. | Prevention and treatment of secondary infections following viral infection |
EP2072052A1 (en) * | 2007-12-17 | 2009-06-24 | Nestec S.A. | Prevention of opportunistic infections in immune-compromised subjects |
NL2001377C2 (nl) | 2008-03-14 | 2009-09-15 | Friesland Brands Bv | Werkwijze voor het isoleren van siaalzuur bevattende oligosachariden, alsmede de hiermee verkrijgbare siaalzuur bevattende oligosachariden bevatttende samenstellingen. |
RU2012107695A (ru) * | 2009-07-31 | 2013-09-10 | Нестек С.А. | Питательная композиция для вскармливаемых грудью детей или домашних животных с пробиотиками и подобранными питательными веществами |
NL2004200C2 (en) * | 2010-02-05 | 2011-08-08 | Friesland Brands Bv | Use of sialyl oligosaccharides in weight management. |
EP2563165A1 (en) * | 2010-04-27 | 2013-03-06 | N.V. Nutricia | Use of 6'-sialyl lactose in infant and toddler nutrition |
CA2822660C (en) * | 2010-12-31 | 2021-09-07 | Abbott Laboratories | Synbiotic combination of probiotic and human milk oligosaccharides |
US20140371173A1 (en) | 2011-02-10 | 2014-12-18 | Nestec S.A. | Modulation of growth of bifidobacteria using a combination of oligosaccharides found in human milk |
-
2012
- 2012-02-03 US US13/984,362 patent/US20140371173A1/en not_active Abandoned
- 2012-02-03 CN CN2012800083041A patent/CN103347405A/zh active Pending
- 2012-02-03 CN CN201410384571.XA patent/CN104126749A/zh active Pending
- 2012-02-03 BR BR112013020108A patent/BR112013020108A2/pt not_active Application Discontinuation
- 2012-02-03 SG SG2013056064A patent/SG192095A1/en unknown
- 2012-02-03 PL PL12707135T patent/PL2672844T3/pl unknown
- 2012-02-03 MY MYPI2013701285A patent/MY161034A/en unknown
- 2012-02-03 WO PCT/IB2012/050511 patent/WO2012107865A2/en active Application Filing
- 2012-02-03 AU AU2012215042A patent/AU2012215042B2/en active Active
- 2012-02-03 RU RU2013141449/13A patent/RU2586928C2/ru active
- 2012-02-03 PT PT127071355T patent/PT2672844E/pt unknown
- 2012-02-03 EP EP12707135.5A patent/EP2672844B2/en active Active
- 2012-02-03 ES ES14177597.3T patent/ES2692533T3/es active Active
- 2012-02-03 ES ES12707135T patent/ES2527200T5/es active Active
- 2012-02-03 MX MX2014008513A patent/MX362129B/es unknown
- 2012-02-03 CA CA2825697A patent/CA2825697A1/en not_active Abandoned
- 2012-02-03 MX MX2013009087A patent/MX345413B/es active IP Right Grant
- 2012-02-03 EP EP14177597.3A patent/EP2792252B1/en active Active
- 2012-02-08 TW TW101104099A patent/TW201244640A/zh unknown
- 2012-02-09 US US13/369,619 patent/US20120208782A1/en not_active Abandoned
-
2013
- 2013-07-15 IL IL227487A patent/IL227487A/en not_active IP Right Cessation
- 2013-08-01 CL CL2013002210A patent/CL2013002210A1/es unknown
- 2013-09-09 ZA ZA2013/06751A patent/ZA201306751B/en unknown
-
2015
- 2015-01-26 US US14/604,951 patent/US20150141367A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2672844B1 (en) | 2014-11-19 |
ZA201306751B (en) | 2015-05-27 |
CN104126749A (zh) | 2014-11-05 |
ES2692533T3 (es) | 2018-12-04 |
EP2672844A2 (en) | 2013-12-18 |
CA2825697A1 (en) | 2012-08-16 |
CL2013002210A1 (es) | 2014-01-10 |
RU2013141449A (ru) | 2015-03-20 |
EP2792252A2 (en) | 2014-10-22 |
IL227487A0 (en) | 2013-09-30 |
EP2792252A3 (en) | 2015-03-25 |
TW201244640A (en) | 2012-11-16 |
SG192095A1 (en) | 2013-08-30 |
EP2672844B2 (en) | 2022-10-05 |
US20120208782A1 (en) | 2012-08-16 |
US20150141367A1 (en) | 2015-05-21 |
MX345413B (es) | 2017-01-27 |
IL227487A (en) | 2015-10-29 |
ES2527200T3 (es) | 2015-01-21 |
CN103347405A (zh) | 2013-10-09 |
ES2527200T5 (es) | 2022-12-29 |
PT2672844E (pt) | 2015-02-04 |
EP2792252B1 (en) | 2018-09-12 |
BR112013020108A2 (pt) | 2017-06-13 |
US20140371173A1 (en) | 2014-12-18 |
WO2012107865A2 (en) | 2012-08-16 |
PL2672844T3 (pl) | 2015-04-30 |
RU2586928C2 (ru) | 2016-06-10 |
AU2012215042B2 (en) | 2016-01-14 |
MY161034A (en) | 2017-04-14 |
WO2012107865A3 (en) | 2012-11-01 |
MX2013009087A (es) | 2013-09-13 |
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