MX355388B - Composiciones farmaceuticas y metodos terapeuticos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto. - Google Patents
Composiciones farmaceuticas y metodos terapeuticos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto.Info
- Publication number
- MX355388B MX355388B MX2015013425A MX2015013425A MX355388B MX 355388 B MX355388 B MX 355388B MX 2015013425 A MX2015013425 A MX 2015013425A MX 2015013425 A MX2015013425 A MX 2015013425A MX 355388 B MX355388 B MX 355388B
- Authority
- MX
- Mexico
- Prior art keywords
- manganese complex
- compound
- combination
- pharmaceutical compositions
- therapeutic methods
- Prior art date
Links
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 title abstract 4
- 229910052748 manganese Inorganic materials 0.000 title abstract 4
- 239000011572 manganese Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 230000001575 pathological effect Effects 0.000 abstract 3
- 239000000969 carrier Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una composición farmacéutica para el tratamiento de una condición patológica en un paciente comprende, como un primer componente, un complejo de manganeso de la Fórmula (I), y, como un segundo componente, un compuesto complejo no de manganeso de la fórmula (I), opcionalmente junto con uno o más portadores y/o excipientes fisiológicamente aceptables, en donde X, R, R, R y R son como se definen en la presente. Métodos para el tratamiento de una condición patológica en un paciente, por ejemplo, una condición patológica causada por la presencia de radicales libres derivados de oxígeno, comprende administrar al paciente el primer componente y el segundo componente.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22320409P | 2009-07-06 | 2009-07-06 | |
| US30634810P | 2010-02-19 | 2010-02-19 | |
| PCT/IB2010/053097 WO2011004325A1 (en) | 2009-07-06 | 2010-07-06 | Pharmaceutical compositions and therapeutic methods employing a combination of a manganese complex compound and a non-manganese complex form of the compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX355388B true MX355388B (es) | 2018-04-17 |
Family
ID=42734866
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012000303A MX336359B (es) | 2009-07-06 | 2010-07-06 | Composiciones farmaceuticas y metodos teraputicos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto. |
| MX2015013425A MX355388B (es) | 2009-07-06 | 2010-07-06 | Composiciones farmaceuticas y metodos terapeuticos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012000303A MX336359B (es) | 2009-07-06 | 2010-07-06 | Composiciones farmaceuticas y metodos teraputicos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10688087B2 (es) |
| EP (1) | EP2451457B1 (es) |
| JP (2) | JP5868852B2 (es) |
| KR (2) | KR101939207B1 (es) |
| CN (2) | CN102481295A (es) |
| AU (1) | AU2010269849B2 (es) |
| BR (1) | BR112012000262A2 (es) |
| CA (1) | CA2767339C (es) |
| ES (1) | ES2665305T3 (es) |
| IL (1) | IL217143A (es) |
| MX (2) | MX336359B (es) |
| RU (1) | RU2563825C2 (es) |
| WO (1) | WO2011004325A1 (es) |
| ZA (1) | ZA201200092B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2451457B1 (en) * | 2009-07-06 | 2018-03-07 | Pledpharma AB | Pharmaceutical compositions and therapeutic methods employing a combination of a manganese complex compound and a non-manganese complex form of the compound |
| CA2862736C (en) | 2012-01-05 | 2020-09-08 | Pledpharma Ab | Mixed metal complexes and methods |
| JP6133250B2 (ja) | 2014-09-18 | 2017-05-24 | 本田技研工業株式会社 | 繊維強化樹脂成形品の成形方法及びその装置 |
| CA3010915C (en) * | 2016-01-11 | 2024-06-04 | Pledpharma Ab | Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions |
| CN110139673B (zh) * | 2016-11-14 | 2022-03-22 | 卡尔森图纳投资公司 | 使用非过渡金属配位的二吡哆基化合物以预防和治疗化疗诱发的psn |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9613182D0 (en) * | 1996-06-24 | 1996-08-28 | Nycomed Imaging As | Method |
| GB9727224D0 (en) | 1997-12-23 | 1998-02-25 | Nycomed Imaging As | Method |
| JP2001527072A (ja) | 1997-12-23 | 2001-12-25 | ニユコメド・イメージング・アクシエセルカペト | 一酸化窒素を放出するキレート化剤およびその治療上の使用 |
| FR2823977B1 (fr) * | 2001-04-26 | 2006-12-01 | Univ Rene Descartes | Utilisation du mangafodipir dans le traitement des effets d'un stress oxydatif |
| US20070148154A1 (en) | 2004-12-17 | 2007-06-28 | Universite Rene Descartes (Paris V) | Use of superoxide dismutase mimetics and reductase gultatione in the form of anticancer drugs |
| WO2009078794A1 (en) * | 2007-12-14 | 2009-06-25 | Pledpharma Ab | Compounds for use in the treatment of cancer |
| EP2451457B1 (en) * | 2009-07-06 | 2018-03-07 | Pledpharma AB | Pharmaceutical compositions and therapeutic methods employing a combination of a manganese complex compound and a non-manganese complex form of the compound |
-
2010
- 2010-07-06 EP EP10740006.1A patent/EP2451457B1/en active Active
- 2010-07-06 ES ES10740006.1T patent/ES2665305T3/es active Active
- 2010-07-06 KR KR1020177027735A patent/KR101939207B1/ko active Active
- 2010-07-06 BR BR112012000262A patent/BR112012000262A2/pt active IP Right Grant
- 2010-07-06 CN CN2010800345628A patent/CN102481295A/zh active Pending
- 2010-07-06 MX MX2012000303A patent/MX336359B/es unknown
- 2010-07-06 JP JP2012519105A patent/JP5868852B2/ja active Active
- 2010-07-06 CA CA2767339A patent/CA2767339C/en active Active
- 2010-07-06 US US13/379,468 patent/US10688087B2/en active Active
- 2010-07-06 WO PCT/IB2010/053097 patent/WO2011004325A1/en not_active Ceased
- 2010-07-06 CN CN201610030809.8A patent/CN105688215A/zh active Pending
- 2010-07-06 KR KR1020127003035A patent/KR101785600B1/ko active Active
- 2010-07-06 AU AU2010269849A patent/AU2010269849B2/en not_active Ceased
- 2010-07-06 RU RU2012103889/15A patent/RU2563825C2/ru active
- 2010-07-06 MX MX2015013425A patent/MX355388B/es unknown
-
2011
- 2011-12-22 IL IL217143A patent/IL217143A/en active IP Right Grant
-
2012
- 2012-01-05 ZA ZA2012/00092A patent/ZA201200092B/en unknown
-
2015
- 2015-09-17 JP JP2015183914A patent/JP6204428B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010269849A1 (en) | 2012-01-19 |
| RU2563825C2 (ru) | 2015-09-20 |
| MX336359B (es) | 2016-01-15 |
| CA2767339A1 (en) | 2011-01-13 |
| AU2010269849B2 (en) | 2015-07-23 |
| CN105688215A (zh) | 2016-06-22 |
| ES2665305T3 (es) | 2018-04-25 |
| JP5868852B2 (ja) | 2016-02-24 |
| ZA201200092B (en) | 2012-09-26 |
| JP6204428B2 (ja) | 2017-09-27 |
| RU2012103889A (ru) | 2013-08-20 |
| JP2016040266A (ja) | 2016-03-24 |
| KR20120052278A (ko) | 2012-05-23 |
| BR112012000262A2 (pt) | 2016-02-16 |
| JP2012532189A (ja) | 2012-12-13 |
| WO2011004325A1 (en) | 2011-01-13 |
| US20120101066A1 (en) | 2012-04-26 |
| KR101785600B1 (ko) | 2017-10-16 |
| EP2451457A1 (en) | 2012-05-16 |
| KR20170117211A (ko) | 2017-10-20 |
| CA2767339C (en) | 2016-05-24 |
| EP2451457B1 (en) | 2018-03-07 |
| US10688087B2 (en) | 2020-06-23 |
| IL217143A (en) | 2016-11-30 |
| CN102481295A (zh) | 2012-05-30 |
| MX2012000303A (es) | 2012-06-01 |
| IL217143A0 (en) | 2012-02-29 |
| KR101939207B1 (ko) | 2019-01-16 |
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