MX355388B - Composiciones farmaceuticas y metodos terapeuticos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto. - Google Patents
Composiciones farmaceuticas y metodos terapeuticos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto.Info
- Publication number
- MX355388B MX355388B MX2015013425A MX2015013425A MX355388B MX 355388 B MX355388 B MX 355388B MX 2015013425 A MX2015013425 A MX 2015013425A MX 2015013425 A MX2015013425 A MX 2015013425A MX 355388 B MX355388 B MX 355388B
- Authority
- MX
- Mexico
- Prior art keywords
- manganese complex
- compound
- combination
- pharmaceutical compositions
- therapeutic methods
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Abstract
Una composición farmacéutica para el tratamiento de una condición patológica en un paciente comprende, como un primer componente, un complejo de manganeso de la Fórmula (I), y, como un segundo componente, un compuesto complejo no de manganeso de la fórmula (I), opcionalmente junto con uno o más portadores y/o excipientes fisiológicamente aceptables, en donde X, R, R, R y R son como se definen en la presente. Métodos para el tratamiento de una condición patológica en un paciente, por ejemplo, una condición patológica causada por la presencia de radicales libres derivados de oxígeno, comprende administrar al paciente el primer componente y el segundo componente.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22320409P | 2009-07-06 | 2009-07-06 | |
| US30634810P | 2010-02-19 | 2010-02-19 | |
| PCT/IB2010/053097 WO2011004325A1 (en) | 2009-07-06 | 2010-07-06 | Pharmaceutical compositions and therapeutic methods employing a combination of a manganese complex compound and a non-manganese complex form of the compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX355388B true MX355388B (es) | 2018-04-17 |
Family
ID=42734866
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012000303A MX336359B (es) | 2009-07-06 | 2010-07-06 | Composiciones farmaceuticas y metodos teraputicos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto. |
| MX2015013425A MX355388B (es) | 2009-07-06 | 2010-07-06 | Composiciones farmaceuticas y metodos terapeuticos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012000303A MX336359B (es) | 2009-07-06 | 2010-07-06 | Composiciones farmaceuticas y metodos teraputicos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10688087B2 (es) |
| EP (1) | EP2451457B1 (es) |
| JP (2) | JP5868852B2 (es) |
| KR (2) | KR101939207B1 (es) |
| CN (2) | CN102481295A (es) |
| AU (1) | AU2010269849B2 (es) |
| BR (1) | BR112012000262A2 (es) |
| CA (1) | CA2767339C (es) |
| ES (1) | ES2665305T3 (es) |
| IL (1) | IL217143A (es) |
| MX (2) | MX336359B (es) |
| RU (1) | RU2563825C2 (es) |
| WO (1) | WO2011004325A1 (es) |
| ZA (1) | ZA201200092B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX336359B (es) * | 2009-07-06 | 2016-01-15 | Pledpharma Ab | Composiciones farmaceuticas y metodos teraputicos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto. |
| WO2013102806A1 (en) | 2012-01-05 | 2013-07-11 | Pledpharma Ab | Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment |
| JP6133250B2 (ja) | 2014-09-18 | 2017-05-24 | 本田技研工業株式会社 | 繊維強化樹脂成形品の成形方法及びその装置 |
| JP7311267B2 (ja) * | 2016-01-11 | 2023-07-19 | エゲティス・セラピューティクス・アーベー | 急性肝不全及び他の肝毒性状態を治療及び／又はこれらから保護するための方法及び製剤 |
| EP3538155B1 (en) * | 2016-11-14 | 2020-09-16 | Karlsson-Tuner Invest AS | Use of non-transition metal coordinated dipyridoxyl compounds to prevent and treat chemotherapy-induced psn |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9613182D0 (en) * | 1996-06-24 | 1996-08-28 | Nycomed Imaging As | Method |
| GB9727224D0 (en) | 1997-12-23 | 1998-02-25 | Nycomed Imaging As | Method |
| ATE277038T1 (de) | 1997-12-23 | 2004-10-15 | Amersham Health As | Stickstoffoxid freisetzende chelatbildner und ihre therapeutische verwendung |
| FR2823977B1 (fr) * | 2001-04-26 | 2006-12-01 | Univ Rene Descartes | Utilisation du mangafodipir dans le traitement des effets d'un stress oxydatif |
| US20070148154A1 (en) | 2004-12-17 | 2007-06-28 | Universite Rene Descartes (Paris V) | Use of superoxide dismutase mimetics and reductase gultatione in the form of anticancer drugs |
| CN101917993B (zh) * | 2007-12-14 | 2013-08-21 | 普莱制药公司 | 用于治疗癌症的化合物 |
| MX336359B (es) * | 2009-07-06 | 2016-01-15 | Pledpharma Ab | Composiciones farmaceuticas y metodos teraputicos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto. |
-
2010
- 2010-07-06 MX MX2012000303A patent/MX336359B/es unknown
- 2010-07-06 ES ES10740006.1T patent/ES2665305T3/es active Active
- 2010-07-06 EP EP10740006.1A patent/EP2451457B1/en active Active
- 2010-07-06 WO PCT/IB2010/053097 patent/WO2011004325A1/en active Application Filing
- 2010-07-06 MX MX2015013425A patent/MX355388B/es unknown
- 2010-07-06 RU RU2012103889/15A patent/RU2563825C2/ru active
- 2010-07-06 KR KR1020177027735A patent/KR101939207B1/ko active IP Right Grant
- 2010-07-06 CN CN2010800345628A patent/CN102481295A/zh active Pending
- 2010-07-06 KR KR1020127003035A patent/KR101785600B1/ko active IP Right Grant
- 2010-07-06 CA CA2767339A patent/CA2767339C/en active Active
- 2010-07-06 CN CN201610030809.8A patent/CN105688215A/zh active Pending
- 2010-07-06 BR BR112012000262A patent/BR112012000262A2/pt not_active Application Discontinuation
- 2010-07-06 US US13/379,468 patent/US10688087B2/en active Active
- 2010-07-06 AU AU2010269849A patent/AU2010269849B2/en active Active
- 2010-07-06 JP JP2012519105A patent/JP5868852B2/ja active Active
-
2011
- 2011-12-22 IL IL217143A patent/IL217143A/en active IP Right Grant
-
2012
- 2012-01-05 ZA ZA2012/00092A patent/ZA201200092B/en unknown
-
2015
- 2015-09-17 JP JP2015183914A patent/JP6204428B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2665305T3 (es) | 2018-04-25 |
| JP6204428B2 (ja) | 2017-09-27 |
| MX2012000303A (es) | 2012-06-01 |
| CN102481295A (zh) | 2012-05-30 |
| EP2451457A1 (en) | 2012-05-16 |
| KR101939207B1 (ko) | 2019-01-16 |
| CN105688215A (zh) | 2016-06-22 |
| AU2010269849A1 (en) | 2012-01-19 |
| AU2010269849B2 (en) | 2015-07-23 |
| RU2012103889A (ru) | 2013-08-20 |
| MX336359B (es) | 2016-01-15 |
| KR20170117211A (ko) | 2017-10-20 |
| IL217143A (en) | 2016-11-30 |
| JP5868852B2 (ja) | 2016-02-24 |
| JP2016040266A (ja) | 2016-03-24 |
| BR112012000262A2 (pt) | 2016-02-16 |
| JP2012532189A (ja) | 2012-12-13 |
| ZA201200092B (en) | 2012-09-26 |
| WO2011004325A1 (en) | 2011-01-13 |
| KR101785600B1 (ko) | 2017-10-16 |
| CA2767339C (en) | 2016-05-24 |
| US20120101066A1 (en) | 2012-04-26 |
| CA2767339A1 (en) | 2011-01-13 |
| KR20120052278A (ko) | 2012-05-23 |
| EP2451457B1 (en) | 2018-03-07 |
| RU2563825C2 (ru) | 2015-09-20 |
| IL217143A0 (en) | 2012-02-29 |
| US10688087B2 (en) | 2020-06-23 |
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