MX346361B - Nanoparticulas que comprenden esteres de poli(metil vinil eter-co-anhidrido maleico) y los usos de las mismas. - Google Patents

Nanoparticulas que comprenden esteres de poli(metil vinil eter-co-anhidrido maleico) y los usos de las mismas.

Info

Publication number
MX346361B
MX346361B MX2013011959A MX2013011959A MX346361B MX 346361 B MX346361 B MX 346361B MX 2013011959 A MX2013011959 A MX 2013011959A MX 2013011959 A MX2013011959 A MX 2013011959A MX 346361 B MX346361 B MX 346361B
Authority
MX
Mexico
Prior art keywords
nanoparticles
poly
maleic anhydride
vinyl ether
methyl vinyl
Prior art date
Application number
MX2013011959A
Other languages
English (en)
Other versions
MX2013011959A (es
Inventor
H A Salman Hesham
Goñi Azcarate Izaskun
Original Assignee
Bionanoplus S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionanoplus S L filed Critical Bionanoplus S L
Publication of MX2013011959A publication Critical patent/MX2013011959A/es
Publication of MX346361B publication Critical patent/MX346361B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5138Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11Encapsulated compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8164Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F265/00Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
    • C08F265/04Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00 on to polymers of esters
    • C08F265/06Polymerisation of acrylate or methacrylate esters on to polymers thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/07Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media from polymer solutions
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/12Powdering or granulating
    • C08J3/126Polymer particles coated by polymer, e.g. core shell structures
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/12Powdering or granulating
    • C08J3/14Powdering or granulating by precipitation from solutions
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04Homopolymers or copolymers of esters
    • C08L33/06Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • C08L33/062Copolymers with monomers not covered by C08L33/06
    • C08L33/064Copolymers with monomers not covered by C08L33/06 containing anhydride, COOH or COOM groups, with M being metal or onium-cation
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10General cosmetic use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/412Microsized, i.e. having sizes between 0.1 and 100 microns
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/12Preparations containing hair conditioners
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2329/00Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
    • C08J2329/10Homopolymers or copolymers of unsaturated ethers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2335/00Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Derivatives of such polymers
    • C08J2335/08Copolymers with vinyl ethers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

Abstract

La presente invención se refiere a nanopartículas para encapsular compuestos, la preparación y los usos de las mismas, basándose dichas nanopartículas en semiésteres de alquilo (C1-C4) de copolímeros de poli (metil vinil éter y anhídrido maleico) (PVM/MA). Dichas nanopartículas pueden encapsular o incorporar un producto de interés para su uso en los sectores agrícola, cosmético, alimentario o farmacéutico.
MX2013011959A 2011-04-15 2012-04-16 Nanoparticulas que comprenden esteres de poli(metil vinil eter-co-anhidrido maleico) y los usos de las mismas. MX346361B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11382115A EP2510930A1 (en) 2011-04-15 2011-04-15 Nanoparticles comprising half esters of poly (methyl vinyl ether-co-maleic anhydride) and uses thereof
PCT/EP2012/056900 WO2012140252A1 (en) 2011-04-15 2012-04-16 Nanoparticles comprising esters of poly (methyl vinyl ether-co-maleic anhydride) and uses thereof

Publications (2)

Publication Number Publication Date
MX2013011959A MX2013011959A (es) 2014-08-29
MX346361B true MX346361B (es) 2017-03-15

Family

ID=44537577

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013011959A MX346361B (es) 2011-04-15 2012-04-16 Nanoparticulas que comprenden esteres de poli(metil vinil eter-co-anhidrido maleico) y los usos de las mismas.

Country Status (11)

Country Link
US (1) US9351940B2 (es)
EP (2) EP2510930A1 (es)
JP (1) JP6001640B2 (es)
CN (1) CN103619918A (es)
AR (1) AR087149A1 (es)
AU (1) AU2012241758B2 (es)
CA (1) CA2833188A1 (es)
ES (1) ES2730119T3 (es)
MX (1) MX346361B (es)
PT (1) PT2699625T (es)
WO (1) WO2012140252A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6275707B2 (ja) 2012-06-20 2018-02-07 フランク・グー 粘膜付着性ナノ粒子送達系
US9878000B2 (en) 2012-06-20 2018-01-30 University Of Waterloo Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof
WO2014164418A1 (en) * 2013-03-11 2014-10-09 North Carolina State University Functionalized environmentally benign nanoparticles
NZ732075A (en) 2014-10-29 2022-09-30 Samson Clinical Pty Ltd Detection and treatment of excessive hair shedding
WO2016071365A1 (en) * 2014-11-03 2016-05-12 Spherium Biomed, S.L. Topical pharmaceutical compositions of paclitaxel
PT3233126T (pt) * 2014-12-01 2019-05-27 Innoup Farma S L Nanopartículas para encapsular compostos, sua preparação e utilizações
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9375478B1 (en) 2015-01-30 2016-06-28 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
CN105343031B (zh) * 2015-11-24 2018-06-15 南京农业大学 一种伊维菌素固体脂质纳米粒及其制备方法
RU2618449C1 (ru) * 2016-01-12 2017-05-03 Александр Александрович Кролевец Способ получения нанокапсул витаминов группы В в каппа-каррагинане
CN107028894B (zh) * 2016-02-03 2020-11-06 三捷生物科技(北京)有限公司 一种载药微球及其制备方法和应用
US10039801B2 (en) 2016-02-16 2018-08-07 Strongbridge Ireland Limited Pharmaceutical compositions of water soluble peptides with poor solubility in isotonic conditions and methods for their use
ES2949140T3 (es) * 2016-03-03 2023-09-25 Boai Nky Medical Holdings Ltd Copolímeros finos y uniformes de sales de metil vinil éter-ácido maleico y su uso en aplicaciones farmacéuticas y para el cuidado bucal
EP3222270A1 (en) 2016-03-23 2017-09-27 Bionanoplus, S.L. Compositions for mucosal adhesion and uses thereof
CN106035397A (zh) * 2016-06-20 2016-10-26 河南中天恒信生物化学科技有限公司 一种生物除草剂及其制备方法
RU2646474C1 (ru) * 2016-09-13 2018-03-05 Александр Александрович Кролевец Способ получения нанокапсул витаминов группы В
WO2019002362A1 (en) * 2017-06-28 2019-01-03 Spherium Biomed, S.L. TOPICAL COMPOSITIONS OF CYCLOSPORIN A
EP3651769B1 (en) * 2017-07-12 2022-01-05 Samson Clinical Pty Ltd. Promoting hair growth and treatment of hair loss or excessive hair shedding
KR101947315B1 (ko) * 2018-05-10 2019-02-12 서울과학기술대학교 산학협력단 티로졸을 함유하는 폴리옥살레이트 나노입자
US11839605B2 (en) * 2018-10-11 2023-12-12 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
WO2021064608A1 (en) * 2019-09-30 2021-04-08 Centitvc - Centro De Nanotecnologia E Materiais Técnicos Funcionais E Inteligentes Capsule for functionalizing a product, method and uses thereof
CN111138786B (zh) * 2020-01-13 2022-07-12 上海应用技术大学 一种壳聚糖plga纳米香精的制备方法与应用
CN111617092A (zh) * 2020-04-20 2020-09-04 牡丹江医学院 一种用于治疗肺癌的药物及其制备方法
CN111777775B (zh) * 2020-07-01 2023-03-31 宁波艾捷康宁生物科技有限公司 一种酰胺型交联聚合物及其制备方法和其在生物蛋白质沉淀中的用途
US11285148B1 (en) 2021-07-23 2022-03-29 King Abdulaziz University Ketoconazole ophthalmic preparations containing trans-ethosomal drug nanoparticles
CN114053229B (zh) * 2022-01-17 2022-04-22 山东国邦药业有限公司 一种盐酸沙拉沙星水溶性颗粒剂及其制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3461461A (en) 1965-11-01 1969-08-12 Upjohn Co 6-amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidines
BE717133A (es) 1968-08-05 1968-12-27
US4139619A (en) 1976-05-24 1979-02-13 The Upjohn Company 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
US4596812A (en) 1976-05-24 1986-06-24 The Upjohn Company Methods and solutions for treating male pattern alopecia
US4164562A (en) * 1977-10-21 1979-08-14 American Cyanamid Company Aerosol hair spray containing an ethyl or butyl monoester of a copolymer of maleic acid and a vinyl monomer
LU83349A1 (fr) 1981-05-08 1983-03-24 Oreal Composition sous forme de mousse aerosol a base de polymere cationique et de polymere anionique
AU629316B2 (en) 1990-04-11 1992-10-01 Flora Inc. Periodontal disease treatment system
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
DE4327063A1 (de) 1993-08-12 1995-02-16 Kirsten Dr Westesen Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften
FR2732595A1 (fr) 1995-04-07 1996-10-11 Oreal Utilisation de polymeres pour reduire l'effet irritant des actifs dans une composition cosmetique et/ou dermatologique
WO1998007410A1 (en) 1996-08-19 1998-02-26 Vivorx Pharmaceuticals, Inc. Methods for the production of protein particles useful for delivery of pharmacological agents
CA2294332C (en) 1997-06-30 2008-08-26 Monsanto Company Microparticles containing agricultural active ingredients
US6149898A (en) * 1998-06-22 2000-11-21 The Procter & Gamble Company Hair styling compositions containing silicone microemulsions and cationic non-polymeric liquids
FR2787729B1 (fr) * 1998-12-29 2001-01-26 Oreal Nanocapsules a base de polymeres anioniques hydrodispersibles, leur procede de preparation et compositions cosmetiques ou dermatologiques les contenant
US20050037374A1 (en) * 1999-11-08 2005-02-17 Melker Richard J. Combined nanotechnology and sensor technologies for simultaneous diagnosis and treatment
JP5527787B2 (ja) 2000-04-07 2014-06-25 大正製薬株式会社 育毛組成物
US7442369B1 (en) 2000-08-09 2008-10-28 Mcneil Ab Compositions of minoxidil
ES2178961B1 (es) 2001-03-06 2004-07-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Fabricacion de nanoparticulas a base del copolimero de metil vinil eter y anhidrido maleico para la administracion de farmacos de naturaleza hidrofilica, en particular de bases puricas y pirimidinicas.
EP1656099B1 (en) * 2003-08-07 2008-04-09 The Procter & Gamble Company Emulsions with a concentrated internal oil phase
US7834210B2 (en) * 2006-08-04 2010-11-16 Bioderm Research Hair loss prevention by natural amino acid and peptide complexes
ES2246694B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
ES2246695B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
DE202004012607U1 (de) 2004-08-12 2004-11-04 Wella Ag Haarbehandlungsmittel mit Gehalt an fluoreszierenden Nanokompositpartikeln
CA2964111A1 (en) 2005-03-29 2006-10-05 The Trustees Of The University Of Pennsylvania Methods for generating new hair folicles, treating baldness, and hair removal
WO2006119960A1 (en) * 2005-05-06 2006-11-16 Unilever Plc Cosmetic composition comprising a micellar, shell cross-linked copolymer
EP1959929A4 (en) 2005-12-14 2012-08-15 Zars Pharma Inc COMPOSITIONS AND METHODS FOR TREATING DERMATOLOGICAL SUFFERING
ES2286951B1 (es) 2006-05-26 2008-10-01 Instituto Cientifico Y Tecnologico De Navarra, S.A Nanoparticulas bioadhesivas para la administracion de moleculas biologicamente activas.
ES2310122B1 (es) 2007-04-20 2009-10-30 Instituto Cientifico Y Tecnologico De Navarra, S.A Nanoparticulas que comprenden una ciclodextrina y una molecula biologicamente activa y sus aplicaciones.
ES2358493B1 (es) 2008-04-05 2012-06-13 Instituto Cientifico Y Tecnologico De Navarra, S.A Nanopartículas pegiladas que comprenden una molécula biológicamente activa y sus aplicaciones.
US8815818B2 (en) 2008-07-18 2014-08-26 Rxi Pharmaceuticals Corporation Phagocytic cell delivery of RNAI
CA2824333A1 (en) 2011-02-10 2012-08-16 Moberg Pharma Ab Novel formulations for dermal, transdermal and mucosal use 1

Also Published As

Publication number Publication date
CA2833188A1 (en) 2012-10-18
MX2013011959A (es) 2014-08-29
AU2012241758A1 (en) 2013-11-14
EP2699625B1 (en) 2019-03-20
PT2699625T (pt) 2019-06-24
US20140161892A1 (en) 2014-06-12
US9351940B2 (en) 2016-05-31
JP2014513082A (ja) 2014-05-29
CN103619918A (zh) 2014-03-05
JP6001640B2 (ja) 2016-10-05
AU2012241758B2 (en) 2016-05-19
EP2510930A1 (en) 2012-10-17
EP2699625A1 (en) 2014-02-26
WO2012140252A1 (en) 2012-10-18
ES2730119T3 (es) 2019-11-08
AR087149A1 (es) 2014-02-26

Similar Documents

Publication Publication Date Title
MX346361B (es) Nanoparticulas que comprenden esteres de poli(metil vinil eter-co-anhidrido maleico) y los usos de las mismas.
HK1209599A1 (en) Products including capsules, uses and preparation thereof
IL234815A0 (en) Heat-manufactured unbreakable pharmaceutical dosage form containing zinc
MX353216B (es) Productos antitranspirantes con proteinas y sales antitranspirantes.
LT3412676T (lt) Cikliniai borono rūgšties dariniai, jų gamybos būdas ir terapinis panaudojimas
UA111542C2 (uk) Похідне складного ефіру 2-амінонікотинової кислоти та бактерицид, що містить зазначене похідне як активний інгредієнт
SG11201406141UA (en) Immortalized stem cells and medicinal composition and medicinal preparation comprising product thereof as active ingredient
WO2012104275A3 (en) Nanoparticles delivery systems, preparation and uses thereof
EA201590161A1 (ru) Составы этанерцепта, отличающиеся заметным уменьшением содержания частиц довидимого диапазона
EP3109307A3 (en) Perfume systems
PL2578596T3 (pl) Lewokarymycyna, kompozycje farmaceutyczne, sposoby otrzymywania i jej zastosowania
MX347734B (es) Anticuerpos anti-s100a4 y usos aplicaciones terapéuticas.
IN2014DN10037A (es)
EP2562172A4 (en) SPHAELACTON DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR THE PRODUCTION AND THEIR USE
IN2015DN03984A (es)
EP3808378A8 (en) Therapeutic proteins with increased half-life and methods of preparing same
TN2012000488A1 (en) Pharmaceutical compositions comprising hydromorphone and naloxone
PL3210990T3 (pl) Lewoizowalerylospiramycyna III i jej preparaty, sposoby wytwarzania i zastosowania
BR112015003917A2 (pt) composição de poliolefina, método de preparo de uma composição de poliolefina, produto de consumo e filme agrícola
MX2014012164A (es) Composiciones a base de probioticos y un complejo de polen de abejas/arcilla, su preparacion y sus usos en nutricion y en terapeutica.
MX2013013691A (es) Composicion de liberacion sostenida que contiene peptidos como ingredientes activos.
WO2011107866A3 (en) Silyl-derivatives of polysaccharides
EP2551266A4 (en) NON-NUCLEOSIDE 2 ', 2-DITHIAZOLE COMPOUNDS, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS AND USES AS HEPATITIS VIRUS INHIBITORS
IT1399398B1 (it) Composizione farmaceutica a base di glicirrizina e polimero eg56 per la preparazione di prodotti ad azione flogolitica.
HK1203061A1 (en) 1,3-diphenylpropane derivatives, preparations and uses thereof 13-

Legal Events

Date Code Title Description
FG Grant or registration