MX340263B - Disposicion de camaras de interaccion y contrapresion para la microfluidizacion. - Google Patents
Disposicion de camaras de interaccion y contrapresion para la microfluidizacion.Info
- Publication number
- MX340263B MX340263B MX2012006214A MX2012006214A MX340263B MX 340263 B MX340263 B MX 340263B MX 2012006214 A MX2012006214 A MX 2012006214A MX 2012006214 A MX2012006214 A MX 2012006214A MX 340263 B MX340263 B MX 340263B
- Authority
- MX
- Mexico
- Prior art keywords
- back pressure
- microfluidization
- pressure chambers
- arranging
- interaction
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
- B01F25/4323—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
- B01F25/52—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle with a rotary stirrer in the recirculation tube
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
- B01F27/2711—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
- B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/82—Combinations of dissimilar mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/82—Combinations of dissimilar mixers
- B01F33/821—Combinations of dissimilar mixers with consecutive receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/82—Combinations of dissimilar mixers
- B01F33/821—Combinations of dissimilar mixers with consecutive receptacles
- B01F33/8212—Combinations of dissimilar mixers with consecutive receptacles with moving and non-moving stirring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0418—Geometrical information
- B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/045—Numerical flow-rate values
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0468—Numerical pressure values
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0472—Numerical temperature values
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0477—Numerical time values
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0481—Numerical speed values
Abstract
La presente invención se refiere a un método mejorado para la manufactura de una emulsión de aceite en agua que comprende utilizar un dispositivo de microfluidización cuya cámara de interacción comprende una pluralidad de canales tipo Z corriente arriba de una cámara de contrapresión.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28354809P | 2009-12-03 | 2009-12-03 | |
PCT/IB2010/003390 WO2011067672A2 (en) | 2009-12-03 | 2010-12-03 | Arranging interaction and back pressure chambers for microfluidization |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012006214A MX2012006214A (es) | 2012-06-19 |
MX340263B true MX340263B (es) | 2016-07-04 |
Family
ID=43927822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012006214A MX340263B (es) | 2009-12-03 | 2010-12-03 | Disposicion de camaras de interaccion y contrapresion para la microfluidizacion. |
Country Status (24)
Country | Link |
---|---|
US (1) | US20130189311A1 (es) |
EP (2) | EP2506833B1 (es) |
JP (2) | JP5751678B2 (es) |
KR (2) | KR101643918B1 (es) |
CN (2) | CN102740832B (es) |
AU (1) | AU2010325751B2 (es) |
BR (1) | BR112012013426B8 (es) |
CA (1) | CA2782650C (es) |
CL (1) | CL2012001398A1 (es) |
DK (1) | DK2380558T4 (es) |
EA (1) | EA031593B1 (es) |
ES (2) | ES2393182T5 (es) |
HK (1) | HK1163505A1 (es) |
HR (1) | HRP20120965T1 (es) |
IL (1) | IL220082B (es) |
MX (1) | MX340263B (es) |
NZ (1) | NZ600254A (es) |
PL (1) | PL2380558T5 (es) |
PT (1) | PT2380558E (es) |
RS (1) | RS52565B (es) |
SG (1) | SG10201501613SA (es) |
SI (2) | SI2506833T1 (es) |
SM (1) | SMT201300026B (es) |
WO (1) | WO2011067672A2 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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DE102007054233B4 (de) * | 2007-11-12 | 2010-06-10 | Ika-Werke Gmbh & Co. Kg | Vorrichtung zum Dispergieren oder Homogenisieren |
CL2012001399A1 (es) | 2009-12-03 | 2013-03-08 | Novartis Ag | Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion. |
EP2506833B1 (en) * | 2009-12-03 | 2014-04-16 | Novartis AG | Arranging interaction and back pressure chambers for microfluidization |
CN105055311A (zh) | 2009-12-03 | 2015-11-18 | 诺华股份有限公司 | 乳液微流化和/或均化期间的组分循环 |
DE102009056884B4 (de) | 2009-12-03 | 2021-03-18 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
MX2012005598A (es) | 2009-12-03 | 2012-05-29 | Novartis Ag | Filtracion hidrofilica durante la fabricacion de adyuvantes de vacuna. |
DE102009056883B4 (de) | 2009-12-03 | 2012-08-16 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
FR2981581B1 (fr) * | 2011-10-20 | 2013-11-29 | Jean-Claude Epiphani | Procede de fabrication d'une emulsion aqueuse d'une substance active huileuse pour application cosmetique, alimentaire ou pharmaceutique |
RU2014140521A (ru) | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
AU2013311702A1 (en) | 2012-09-06 | 2015-02-19 | Novartis Ag | Combination vaccines with serogroup B meningococcus and D/T/P |
EP2906239A1 (en) | 2012-10-12 | 2015-08-19 | GlaxoSmithKline Biologicals SA | Non-cross-linked acellular pertussis antigens for use in combination vaccines |
CN105007935A (zh) | 2012-12-18 | 2015-10-28 | 葛兰素史密丝克莱恩生物有限公司 | 用于保护免于白喉和/或破伤风的缀合物 |
EP3708143A1 (fr) * | 2012-12-27 | 2020-09-16 | Jean-Claude Epiphani | Procédé de fabrication d'une émulsion aqueuse d'une substance active huileuse pour application cosmétique, alimentaire ou pharmaceutique |
EP3148684A4 (en) * | 2014-05-30 | 2018-06-27 | Microfluidics International Corporation | Interaction chambers with reduced cavitation |
EP4144369A1 (en) | 2014-09-26 | 2023-03-08 | Seqirus UK Limited | Vaccination of immunocompromised subjects |
KR20170063750A (ko) | 2014-09-26 | 2017-06-08 | 세퀴러스 유케이 리미티드 | 면역손상된 대상체의 백신 접종 |
EP3226904B1 (en) | 2014-12-02 | 2019-03-06 | Novartis AG | Manufacture of surfactant-containing compositions |
KR102079141B1 (ko) | 2016-05-11 | 2020-02-19 | 주식회사 엘지화학 | 고압 균질화 장치 및 이를 이용한 그래핀의 제조방법 |
JP2019163345A (ja) * | 2016-08-02 | 2019-09-26 | 京都プラント工業株式会社 | バイオ燃料の製造方法 |
JP2019528728A (ja) * | 2016-09-29 | 2019-10-17 | 高雄醫學大學Kaohsiung Medical University | 組織から細胞を分離する装置 |
DE102018205493A1 (de) * | 2018-04-11 | 2019-10-17 | B. Braun Melsungen Ag | Verfahren zur Herstellung einer O/W-Emulsion, O/W-Emulsion und Anlage zur Herstellung einer O/W-Emulsion |
EP4309773A1 (en) * | 2022-06-08 | 2024-01-24 | Contemporary Amperex Technology Co., Limited | Mixed dispersion device |
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FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
GB0622282D0 (en) | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
SG177141A1 (en) * | 2006-12-06 | 2012-01-30 | Novartis Ag | Vaccines including antigen from four strains of influenza virus |
US8187554B2 (en) * | 2008-04-23 | 2012-05-29 | Microfluidics International Corporation | Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems |
EP2506833B1 (en) * | 2009-12-03 | 2014-04-16 | Novartis AG | Arranging interaction and back pressure chambers for microfluidization |
MX2012005598A (es) † | 2009-12-03 | 2012-05-29 | Novartis Ag | Filtracion hidrofilica durante la fabricacion de adyuvantes de vacuna. |
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