MX2939E - Procedimiento para la preparacion de 1 - r - 3 - pirrol idinil - alfa , fenil - alfa ( 2 - piridinil ) metanos - Google Patents

Procedimiento para la preparacion de 1 - r - 3 - pirrol idinil - alfa , fenil - alfa ( 2 - piridinil ) metanos

Info

Publication number
MX2939E
MX2939E MX006621U MX662175U MX2939E MX 2939 E MX2939 E MX 2939E MX 006621 U MX006621 U MX 006621U MX 662175 U MX662175 U MX 662175U MX 2939 E MX2939 E MX 2939E
Authority
MX
Mexico
Prior art keywords
alfa
preparation
see
lower alkyl
metanos
Prior art date
Application number
MX006621U
Other languages
English (en)
Inventor
William John Welstead Jr
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of MX2939E publication Critical patent/MX2939E/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de 1 - r - 3 pirrol idinil alfa - fenil - alfa ( 2 - piridil ) - metanos que tienen la fórmula (VER FIGURA) en donde R representa alquilo inferior, ciclo alquilo inferior o fenil alquilo inferior e Y representa hidrógeno, caracterizado por hacer reaccionar un aceto nitrilo de la fórmula general (VER FIGURA) en donde R es como se define arriba e Y es un radical ciano con amida sódica; secar y poner a reflujo la mezcla de reacción; enfriar la mezcla y separar las capas que se forman; lavar y secar la fase orgánica para dar un compuesto de la fórmula general (VER FIGURA) en donde R se define como arriba e Y es hidrógeno.
MX006621U 1974-12-26 1975-12-17 Procedimiento para la preparacion de 1 - r - 3 - pirrol idinil - alfa , fenil - alfa ( 2 - piridinil ) metanos MX2939E (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/536,521 US3984557A (en) 1974-12-26 1974-12-26 Antiarrhythmia compositions and methods

Publications (1)

Publication Number Publication Date
MX2939E true MX2939E (es) 1980-01-02

Family

ID=24138838

Family Applications (1)

Application Number Title Priority Date Filing Date
MX006621U MX2939E (es) 1974-12-26 1975-12-17 Procedimiento para la preparacion de 1 - r - 3 - pirrol idinil - alfa , fenil - alfa ( 2 - piridinil ) metanos

Country Status (8)

Country Link
US (1) US3984557A (es)
CA (1) CA1054059A (es)
DE (1) DE2558502A1 (es)
FR (1) FR2295749A1 (es)
GB (1) GB1519210A (es)
MX (1) MX2939E (es)
PH (1) PH13490A (es)
ZA (1) ZA757973B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0235463A3 (en) * 1985-12-20 1990-01-17 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents
KR100738229B1 (ko) * 2001-12-31 2007-07-12 한국화학연구원 신규한 피롤리디닐피리딘 유도체
TWI295669B (en) * 2002-10-30 2008-04-11 Theravance Inc Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
EP1615881A2 (en) * 2003-04-01 2006-01-18 Theravance, Inc. Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
JP2007524641A (ja) * 2003-07-11 2007-08-30 セラヴァンス， インコーポレーテッド 置換４−アミノ−１−ベンジルピペリジン化合物
US7250414B2 (en) * 2004-03-11 2007-07-31 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
US7071224B2 (en) * 2004-03-11 2006-07-04 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192210A (en) * 1961-12-04 1965-06-29 Robins Co Inc A H 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones
US3192206A (en) * 1961-12-04 1965-06-29 Robins Co Inc A H 4-(omega-aminoalkyl)-3, 3-disubstitutedn-hydrocarbon-2-pyrrolidinones and corresponding-2-thionpyrrolidinones
US3509171A (en) * 1967-09-14 1970-04-28 Robins Co Inc A H 3-amino-1-carbamyl and thiocarbamyl pyrrolidines
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines

Also Published As

Publication number Publication date
CA1054059A (en) 1979-05-08
FR2295749A1 (fr) 1976-07-23
FR2295749B1 (es) 1979-09-21
US3984557A (en) 1976-10-05
DE2558502C2 (es) 1988-06-09
ZA757973B (en) 1976-12-29
PH13490A (en) 1980-05-21
DE2558502A1 (de) 1976-07-08
GB1519210A (en) 1978-07-26

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