MX2939E - Procedimiento para la preparacion de 1 - r - 3 - pirrol idinil - alfa , fenil - alfa ( 2 - piridinil ) metanos - Google Patents
Procedimiento para la preparacion de 1 - r - 3 - pirrol idinil - alfa , fenil - alfa ( 2 - piridinil ) metanosInfo
- Publication number
- MX2939E MX2939E MX006621U MX662175U MX2939E MX 2939 E MX2939 E MX 2939E MX 006621 U MX006621 U MX 006621U MX 662175 U MX662175 U MX 662175U MX 2939 E MX2939 E MX 2939E
- Authority
- MX
- Mexico
- Prior art keywords
- alfa
- preparation
- see
- lower alkyl
- metanos
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de 1 - r - 3 pirrol idinil alfa - fenil - alfa ( 2 - piridil ) - metanos que tienen la fórmula (VER FIGURA) en donde R representa alquilo inferior, ciclo alquilo inferior o fenil alquilo inferior e Y representa hidrógeno, caracterizado por hacer reaccionar un aceto nitrilo de la fórmula general (VER FIGURA) en donde R es como se define arriba e Y es un radical ciano con amida sódica; secar y poner a reflujo la mezcla de reacción; enfriar la mezcla y separar las capas que se forman; lavar y secar la fase orgánica para dar un compuesto de la fórmula general (VER FIGURA) en donde R se define como arriba e Y es hidrógeno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/536,521 US3984557A (en) | 1974-12-26 | 1974-12-26 | Antiarrhythmia compositions and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2939E true MX2939E (es) | 1980-01-02 |
Family
ID=24138838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX006621U MX2939E (es) | 1974-12-26 | 1975-12-17 | Procedimiento para la preparacion de 1 - r - 3 - pirrol idinil - alfa , fenil - alfa ( 2 - piridinil ) metanos |
Country Status (8)
Country | Link |
---|---|
US (1) | US3984557A (es) |
CA (1) | CA1054059A (es) |
DE (1) | DE2558502A1 (es) |
FR (1) | FR2295749A1 (es) |
GB (1) | GB1519210A (es) |
MX (1) | MX2939E (es) |
PH (1) | PH13490A (es) |
ZA (1) | ZA757973B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0235463A3 (en) * | 1985-12-20 | 1990-01-17 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents |
KR100738229B1 (ko) * | 2001-12-31 | 2007-07-12 | 한국화학연구원 | 신규한 피롤리디닐피리딘 유도체 |
TWI295669B (en) * | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
US7317102B2 (en) * | 2003-04-01 | 2008-01-08 | Theravance, Inc. | Diarylmethyl and related compounds |
TW200510298A (en) * | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
EP1644356A1 (en) * | 2003-07-11 | 2006-04-12 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
JP2007528418A (ja) * | 2004-03-11 | 2007-10-11 | セラヴァンス, インコーポレーテッド | ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物 |
JP2007528414A (ja) * | 2004-03-11 | 2007-10-11 | セラヴァンス, インコーポレーテッド | ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3192210A (en) * | 1961-12-04 | 1965-06-29 | Robins Co Inc A H | 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones |
US3192206A (en) * | 1961-12-04 | 1965-06-29 | Robins Co Inc A H | 4-(omega-aminoalkyl)-3, 3-disubstitutedn-hydrocarbon-2-pyrrolidinones and corresponding-2-thionpyrrolidinones |
US3509171A (en) * | 1967-09-14 | 1970-04-28 | Robins Co Inc A H | 3-amino-1-carbamyl and thiocarbamyl pyrrolidines |
GB1242169A (en) * | 1969-04-09 | 1971-08-11 | Ucb Sa | Piperidine derivatives |
US3806526A (en) * | 1972-01-28 | 1974-04-23 | Richardson Merrell Inc | 1-aroylalkyl-4-diphenylmethyl piperidines |
-
1974
- 1974-12-26 US US05/536,521 patent/US3984557A/en not_active Expired - Lifetime
-
1975
- 1975-12-17 MX MX006621U patent/MX2939E/es unknown
- 1975-12-23 FR FR7539570A patent/FR2295749A1/fr active Granted
- 1975-12-23 GB GB52611/75A patent/GB1519210A/en not_active Expired
- 1975-12-23 CA CA242,430A patent/CA1054059A/en not_active Expired
- 1975-12-23 ZA ZA00757973A patent/ZA757973B/xx unknown
- 1975-12-24 DE DE19752558502 patent/DE2558502A1/de active Granted
- 1975-12-24 PH PH17927A patent/PH13490A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US3984557A (en) | 1976-10-05 |
GB1519210A (en) | 1978-07-26 |
DE2558502A1 (de) | 1976-07-08 |
FR2295749B1 (es) | 1979-09-21 |
CA1054059A (en) | 1979-05-08 |
ZA757973B (en) | 1976-12-29 |
PH13490A (en) | 1980-05-21 |
DE2558502C2 (es) | 1988-06-09 |
FR2295749A1 (fr) | 1976-07-23 |
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