MX2023010774A - Pauta posologica de sotorasib. - Google Patents
Pauta posologica de sotorasib.Info
- Publication number
- MX2023010774A MX2023010774A MX2023010774A MX2023010774A MX2023010774A MX 2023010774 A MX2023010774 A MX 2023010774A MX 2023010774 A MX2023010774 A MX 2023010774A MX 2023010774 A MX2023010774 A MX 2023010774A MX 2023010774 A MX2023010774 A MX 2023010774A
- Authority
- MX
- Mexico
- Prior art keywords
- sotorasib
- dosing regimen
- patient
- total daily
- daily dose
- Prior art date
Links
- NXQKSXLFSAEQCZ-SFHVURJKSA-N sotorasib Chemical compound FC1=CC2=C(N(C(N=C2N2[C@H](CN(CC2)C(C=C)=O)C)=O)C=2C(=NC=CC=2C)C(C)C)N=C1C1=C(C=CC=C1O)F NXQKSXLFSAEQCZ-SFHVURJKSA-N 0.000 title abstract 5
- 229940073531 sotorasib Drugs 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 102200006538 rs121913530 Human genes 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract
En el presente documento se proporcionan métodos de administración de una dosis diaria total de 240 mg de sotorasib a un paciente que padece un cáncer que tiene una mutación KRAS G12C. En el presente documento también se proporcionan métodos para tratar un cáncer con mutación KRAS G12C en un paciente, que comprenden la administración de una dosis diaria total de 960 mg de sotorasib al paciente, y la reducción de la dosis diaria total de sotorasib a 480 mg en un paciente que experimenta un acontecimiento adverso a la dosis de 960 mg de sotorasib.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163162273P | 2021-03-17 | 2021-03-17 | |
US202163185054P | 2021-05-06 | 2021-05-06 | |
US202163190096P | 2021-05-18 | 2021-05-18 | |
PCT/US2022/020642 WO2022197865A1 (en) | 2021-03-17 | 2022-03-16 | Sotorasib dosing regimen |
Publications (1)
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WO2024091463A1 (en) * | 2022-10-24 | 2024-05-02 | Amgen Inc. | Methods of treating cancer with sotorasib |
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US20110245201A1 (en) * | 2009-09-15 | 2011-10-06 | John Ryan | Treatment of cancer |
EP2854811A1 (en) * | 2012-05-31 | 2015-04-08 | Amgen Inc. | Use of amg 900 for the treatment of cancer |
US10328062B2 (en) * | 2014-04-04 | 2019-06-25 | Amgen, Inc. | Biomarkers and use of MET inhibitor for treatment of cancer |
JP2021509680A (ja) * | 2018-01-08 | 2021-04-01 | ジー1、セラピューティクス、インコーポレイテッドG1 Therapeutics, Inc. | G1t38の優れた投与レジメン |
EP3738593A1 (en) * | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
US11236091B2 (en) * | 2019-05-21 | 2022-02-01 | Amgen Inc. | Solid state forms |
IL293206A (en) * | 2019-11-27 | 2022-07-01 | Turning Point Therapeutics Inc | Combination therapy involving diaryl macrocyclic compounds |
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CA3212705A1 (en) | 2022-09-22 |
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KR20230157379A (ko) | 2023-11-16 |
AU2022239491A1 (en) | 2023-09-07 |
BR112023018734A2 (pt) | 2023-10-24 |
UY39673A (es) | 2022-10-31 |
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