MX2023009095A - Compounds and methods for reducing tau expression. - Google Patents

Compounds and methods for reducing tau expression.

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Publication number
MX2023009095A
MX2023009095A MX2023009095A MX2023009095A MX2023009095A MX 2023009095 A MX2023009095 A MX 2023009095A MX 2023009095 A MX2023009095 A MX 2023009095A MX 2023009095 A MX2023009095 A MX 2023009095A MX 2023009095 A MX2023009095 A MX 2023009095A
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MX
Mexico
Prior art keywords
compounds
methods
reducing
animal
cell
Prior art date
Application number
MX2023009095A
Other languages
Spanish (es)
Inventor
Holly Kordasiewicz
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Biogen Ma Inc
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Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of MX2023009095A publication Critical patent/MX2023009095A/en

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    • C12N2310/3525—MOE, methoxyethoxy

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Abstract

Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of Tau mRNA in a cell or animal, and in certain instances reducing the amount of Tau protein in a cell or animal. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom of a neurodegenerative disease. Such symptoms include loss of memory, loss of motor function, and increase in the number and/or volume of neurofibrillary inclusions. Such neurodegenerative diseases include tauopathies, Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy (PSP), Chronic Traumatic Encephalopathy (CTE), Corticobasal Ganglionic Degeneration (CBD), Epilepsy, and Dravet's Syndrome.
MX2023009095A 2016-09-29 2019-03-28 Compounds and methods for reducing tau expression. MX2023009095A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662401723P 2016-09-29 2016-09-29
US201762450469P 2017-01-25 2017-01-25

Publications (1)

Publication Number Publication Date
MX2023009095A true MX2023009095A (en) 2023-08-09

Family

ID=61760152

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019003633A MX2019003633A (en) 2016-09-29 2017-09-29 Compounds and methods for reducing tau expression.
MX2023009095A MX2023009095A (en) 2016-09-29 2019-03-28 Compounds and methods for reducing tau expression.

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MX2019003633A MX2019003633A (en) 2016-09-29 2017-09-29 Compounds and methods for reducing tau expression.

Country Status (30)

Country Link
US (3) US10407680B2 (en)
EP (2) EP4335923A3 (en)
JP (4) JP6738004B2 (en)
KR (2) KR20210097228A (en)
CN (2) CN113481201A (en)
AU (3) AU2017336093B2 (en)
BR (2) BR112019003162B1 (en)
CA (1) CA3038891A1 (en)
CL (2) CL2019000703A1 (en)
CO (1) CO2019001385A2 (en)
CR (2) CR20190214A (en)
DK (1) DK3519572T5 (en)
ES (1) ES2963428T3 (en)
FI (1) FI3519572T3 (en)
HR (1) HRP20231606T1 (en)
HU (1) HUE065170T2 (en)
IL (3) IL299615A (en)
JO (1) JOP20190065A1 (en)
LT (1) LT3519572T (en)
MD (1) MD3519572T2 (en)
MX (2) MX2019003633A (en)
NZ (1) NZ750642A (en)
PE (1) PE20190655A1 (en)
PL (1) PL3519572T3 (en)
PT (1) PT3519572T (en)
RS (1) RS64941B1 (en)
SG (1) SG11201901140QA (en)
SI (1) SI3519572T1 (en)
WO (1) WO2018064593A1 (en)
ZA (2) ZA201900920B (en)

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EP2839006B1 (en) * 2012-04-20 2018-01-03 Ionis Pharmaceuticals, Inc. Oligomeric compounds comprising bicyclic nucleotides and uses thereof
EP2971142B1 (en) 2013-03-14 2020-06-24 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating tau expression
TWI657819B (en) 2013-07-19 2019-05-01 美商Ionis製藥公司 Compositions for modulating tau expression
JOP20190065A1 (en) 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc Compounds and methods for reducing tau expression
US11447775B2 (en) 2018-01-12 2022-09-20 Bristol-Myers Squibb Company Antisense oligonucleotides targeting alpha-synuclein and uses thereof
PE20210346A1 (en) 2018-07-03 2021-02-25 Hoffmann La Roche OLIGONUCLEOTIDES TO MODULATE THE EXPRESSION OF TAU
WO2022125984A1 (en) * 2020-12-11 2022-06-16 Eisai R&D Management Co., Ltd. Tau-targeting oligonucleotide gapmers
EP4312977A1 (en) 2021-04-01 2024-02-07 Biogen MA Inc. Nucleic acid delivery to the central nervous system
BR112023026050A2 (en) 2021-06-18 2024-03-05 Ionis Pharmaceuticals Inc COMPOUNDS AND METHODS TO REDUCE IFNAR1 EXPRESSION
EP4373938A2 (en) * 2021-07-23 2024-05-29 University Of Kentucky Research Foundation Inhibition of neurofibrillary tangles using oligonucleotides against circular rnas from the microtubule associated protein tau (mapt) locus
JP2024527896A (en) * 2021-07-23 2024-07-26 バイオジェン・エムエイ・インコーポレイテッド Methods for reducing tau expression

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