MX2023009095A - Compounds and methods for reducing tau expression. - Google Patents
Compounds and methods for reducing tau expression.Info
- Publication number
- MX2023009095A MX2023009095A MX2023009095A MX2023009095A MX2023009095A MX 2023009095 A MX2023009095 A MX 2023009095A MX 2023009095 A MX2023009095 A MX 2023009095A MX 2023009095 A MX2023009095 A MX 2023009095A MX 2023009095 A MX2023009095 A MX 2023009095A
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- Mexico
- Prior art keywords
- compounds
- methods
- reducing
- animal
- cell
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000013498 tau Proteins Human genes 0.000 title abstract 3
- 108010026424 tau Proteins Proteins 0.000 title abstract 3
- 201000011240 Frontotemporal dementia Diseases 0.000 abstract 3
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 abstract 2
- 208000011990 Corticobasal Degeneration Diseases 0.000 abstract 2
- 208000017004 dementia pugilistica Diseases 0.000 abstract 2
- 230000004770 neurodegeneration Effects 0.000 abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 201000007547 Dravet syndrome Diseases 0.000 abstract 1
- 208000024658 Epilepsy syndrome Diseases 0.000 abstract 1
- 208000002877 Epileptic Syndromes Diseases 0.000 abstract 1
- 102100040243 Microtubule-associated protein tau Human genes 0.000 abstract 1
- 208000036572 Myoclonic epilepsy Diseases 0.000 abstract 1
- 206010073677 Severe myoclonic epilepsy of infancy Diseases 0.000 abstract 1
- 208000034799 Tauopathies Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 231100000863 loss of memory Toxicity 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 230000007659 motor function Effects 0.000 abstract 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3525—MOE, methoxyethoxy
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- Bioinformatics & Cheminformatics (AREA)
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- Animal Behavior & Ethology (AREA)
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Abstract
Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of Tau mRNA in a cell or animal, and in certain instances reducing the amount of Tau protein in a cell or animal. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom of a neurodegenerative disease. Such symptoms include loss of memory, loss of motor function, and increase in the number and/or volume of neurofibrillary inclusions. Such neurodegenerative diseases include tauopathies, Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy (PSP), Chronic Traumatic Encephalopathy (CTE), Corticobasal Ganglionic Degeneration (CBD), Epilepsy, and Dravet's Syndrome.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662401723P | 2016-09-29 | 2016-09-29 | |
US201762450469P | 2017-01-25 | 2017-01-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023009095A true MX2023009095A (en) | 2023-08-09 |
Family
ID=61760152
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019003633A MX2019003633A (en) | 2016-09-29 | 2017-09-29 | Compounds and methods for reducing tau expression. |
MX2023009095A MX2023009095A (en) | 2016-09-29 | 2019-03-28 | Compounds and methods for reducing tau expression. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019003633A MX2019003633A (en) | 2016-09-29 | 2017-09-29 | Compounds and methods for reducing tau expression. |
Country Status (30)
Country | Link |
---|---|
US (2) | US10407680B2 (en) |
EP (2) | EP4335923A3 (en) |
JP (4) | JP6738004B2 (en) |
KR (2) | KR102286223B1 (en) |
CN (2) | CN109790543B (en) |
AU (3) | AU2017336093B2 (en) |
BR (2) | BR112019003162B1 (en) |
CA (1) | CA3038891A1 (en) |
CL (2) | CL2019000703A1 (en) |
CO (1) | CO2019001385A2 (en) |
CR (2) | CR20190214A (en) |
DK (1) | DK3519572T3 (en) |
ES (1) | ES2963428T3 (en) |
FI (1) | FI3519572T3 (en) |
HR (1) | HRP20231606T1 (en) |
HU (1) | HUE065170T2 (en) |
IL (3) | IL299615A (en) |
JO (1) | JOP20190065A1 (en) |
LT (1) | LT3519572T (en) |
MD (1) | MD3519572T2 (en) |
MX (2) | MX2019003633A (en) |
NZ (1) | NZ750642A (en) |
PE (1) | PE20190655A1 (en) |
PL (1) | PL3519572T3 (en) |
PT (1) | PT3519572T (en) |
RS (1) | RS64941B1 (en) |
SG (1) | SG11201901140QA (en) |
SI (1) | SI3519572T1 (en) |
WO (1) | WO2018064593A1 (en) |
ZA (2) | ZA201900920B (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6492003B2 (en) | 2012-03-30 | 2019-03-27 | ワシントン・ユニバーシティWashington University | Methods of modulating tau expression to reduce stroke and to modify neurodegenerative syndrome |
EP2839006B1 (en) * | 2012-04-20 | 2018-01-03 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
CA2906119A1 (en) | 2013-03-14 | 2014-09-25 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulating tau expression |
TWI772856B (en) | 2013-07-19 | 2022-08-01 | 美商百健Ma公司 | Compositions for modulating tau expression |
JOP20190065A1 (en) | 2016-09-29 | 2019-03-28 | Ionis Pharmaceuticals Inc | Compounds and methods for reducing tau expression |
WO2019140231A1 (en) | 2018-01-12 | 2019-07-18 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
CN112567033A (en) | 2018-07-03 | 2021-03-26 | 豪夫迈·罗氏有限公司 | Oligonucleotides for modulating Tau expression |
US20220195437A1 (en) * | 2020-12-11 | 2022-06-23 | Eisai R&D Management Co., Ltd. | Tau-targeting oligonucleotide gapmers |
AR125267A1 (en) | 2021-04-01 | 2023-06-28 | Biogen Ma Inc | DELIVERY OF NUCLEIC ACID TO THE CENTRAL NERVOUS SYSTEM |
BR112023026050A2 (en) * | 2021-06-18 | 2024-03-05 | Ionis Pharmaceuticals Inc | COMPOUNDS AND METHODS TO REDUCE IFNAR1 EXPRESSION |
EP4373938A2 (en) * | 2021-07-23 | 2024-05-29 | University Of Kentucky Research Foundation | Inhibition of neurofibrillary tangles using oligonucleotides against circular rnas from the microtubule associated protein tau (mapt) locus |
PE20240648A1 (en) * | 2021-07-23 | 2024-04-04 | Biogen Ma Inc | METHODS TO REDUCE TAU EXPRESSION |
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