MX2023008091A - Soluciones estables de compuestos imidos inmunomoduladores para uso parenteral. - Google Patents
Soluciones estables de compuestos imidos inmunomoduladores para uso parenteral.Info
- Publication number
- MX2023008091A MX2023008091A MX2023008091A MX2023008091A MX2023008091A MX 2023008091 A MX2023008091 A MX 2023008091A MX 2023008091 A MX2023008091 A MX 2023008091A MX 2023008091 A MX2023008091 A MX 2023008091A MX 2023008091 A MX2023008091 A MX 2023008091A
- Authority
- MX
- Mexico
- Prior art keywords
- parenteral use
- stable
- stable solutions
- solutions
- imid
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- -1 imide compounds Chemical class 0.000 title 1
- 229940127079 antineoplastic immunimodulatory agent Drugs 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 229960004942 lenalidomide Drugs 0.000 abstract 2
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyrrole Compounds (AREA)
Abstract
Se proporcionan composiciones que comprenden una solución estable de un agente de una enfermedad inflamatoria inmunomediada (IMID), como, por ejemplo, un fármaco de imida inmunomoduladora (IMiD) que incluye, entre otros, lenalidomida (LLD). Más particularmente, las modalidades se refiere soluciones estables de IMiD para su uso parenteral. También se proporcionan métodos para preparar soluciones estables de IMiD. En algunas modalidades, se proporcionan métodos para tratar los trastornos inflamatorios y cáncer(es) por medio del uso parenteral de las soluciones de IMiD estables, y las formulaciones de las mismas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163135347P | 2021-01-08 | 2021-01-08 | |
PCT/US2022/011572 WO2022150561A1 (en) | 2021-01-08 | 2022-01-07 | Stable solutions of immunomodulatory imide compounds for parenteral use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023008091A true MX2023008091A (es) | 2023-07-14 |
Family
ID=80218564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023008091A MX2023008091A (es) | 2021-01-08 | 2022-01-07 | Soluciones estables de compuestos imidos inmunomoduladores para uso parenteral. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20220218687A1 (es) |
EP (1) | EP4251131A1 (es) |
JP (1) | JP2024503001A (es) |
KR (1) | KR20230129468A (es) |
CN (1) | CN117098531A (es) |
AU (1) | AU2022206272A1 (es) |
CA (1) | CA3204385A1 (es) |
MX (1) | MX2023008091A (es) |
WO (1) | WO2022150561A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2020263285A1 (en) * | 2019-04-22 | 2021-10-28 | Starton Therapeutics, Inc. | Continuous delivery of lenalidomide and other immunomodulatory agents |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
CN101336890A (zh) * | 2008-05-30 | 2009-01-07 | 济南基福医药科技有限公司 | 一种抗癌缓释凝胶注射剂 |
CA2774015A1 (en) * | 2009-09-15 | 2011-03-24 | Cerulean Pharma Inc. | A cdp-camptothecin conjugate, particle or composition and uses thereof |
US9724329B2 (en) * | 2010-06-21 | 2017-08-08 | Peter Maccallum Cancer Institute | Stimulating immune response |
US20120208755A1 (en) * | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
AU2016378482A1 (en) * | 2015-12-22 | 2018-07-12 | Synthon B.V. | Pharmaceutical composition comprising amorphous lenalidomide and an antioxidant |
CN109310624A (zh) * | 2016-06-15 | 2019-02-05 | 托伦特药物有限公司 | 阿普斯特的局部组合物 |
WO2018089829A1 (en) * | 2016-11-10 | 2018-05-17 | Fortis Therapeutics, Inc. | Cd46-specific effector cells and uses thereof |
AU2020263285A1 (en) * | 2019-04-22 | 2021-10-28 | Starton Therapeutics, Inc. | Continuous delivery of lenalidomide and other immunomodulatory agents |
-
2022
- 2022-01-07 CA CA3204385A patent/CA3204385A1/en active Pending
- 2022-01-07 EP EP22702817.2A patent/EP4251131A1/en active Pending
- 2022-01-07 WO PCT/US2022/011572 patent/WO2022150561A1/en active Application Filing
- 2022-01-07 US US17/570,463 patent/US20220218687A1/en active Pending
- 2022-01-07 KR KR1020237026371A patent/KR20230129468A/ko unknown
- 2022-01-07 MX MX2023008091A patent/MX2023008091A/es unknown
- 2022-01-07 AU AU2022206272A patent/AU2022206272A1/en active Pending
- 2022-01-07 CN CN202280020012.3A patent/CN117098531A/zh active Pending
- 2022-01-07 JP JP2023541287A patent/JP2024503001A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2024503001A (ja) | 2024-01-24 |
KR20230129468A (ko) | 2023-09-08 |
WO2022150561A1 (en) | 2022-07-14 |
AU2022206272A1 (en) | 2023-07-27 |
CN117098531A (zh) | 2023-11-21 |
EP4251131A1 (en) | 2023-10-04 |
US20220218687A1 (en) | 2022-07-14 |
CA3204385A1 (en) | 2022-07-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11932643B2 (en) | Substituted heterocyclic inhibitors of PTPN11 | |
US20210196695A1 (en) | K-ras modulators | |
US20200048249A1 (en) | Ptpn11 inhibitors | |
EA202092320A1 (ru) | Гетеробициклические ингибиторы mat2a и способы использования для лечения злокачественной опухоли | |
MX2022005053A (es) | Inhibidores de peque?as moleculas de mutante g12c de kras. | |
RU2463298C2 (ru) | Производные 5-замещенного хиназолинона, содержащие их композиции и способы их применения | |
CR20230066A (es) | Agonistas del glp-1 heterocíclicos | |
MA34604B1 (fr) | Derives de la pyrazine en tant que bloqueurs de l'enac | |
CR20200403A (es) | Macrociclos como moduladores del regular de conductancia transmenbrana de la fibrosis quística, composiciones farmacéuticas de estos, su uso en el tratamiento de la fibrosisquística y procesos para elaborarlos | |
US10246462B2 (en) | Chemokine receptor modulators and uses thereof | |
CR20220371A (es) | Agonistas heterocíclicos de glp-1 | |
HRP20050967B8 (hr) | Derivati pirazolo-kinazolina, postupak njihovog dobivanja i njihova uporaba kao inhibitora kinaze | |
CN112218850A (zh) | 整合应激通路的调节剂 | |
MX2019011530A (es) | Saxitoxinas 11,13-modificadas para el tratamiento del dolor. | |
MX2007003327A (es) | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. | |
UA84175C2 (ru) | Гетероциклические ингибиторы мэк и их применение | |
CA2493225A1 (en) | Quinoline derivatives and their use as mycobacterial inhibitors | |
MX2010007714A (es) | Piridinas fusionadas activas como inhibidores de c-met. | |
CN102612367A (zh) | 脯氨酰羟化酶抑制剂 | |
MA30487B1 (fr) | Nouveaux composes heterocycliques | |
MX2023008091A (es) | Soluciones estables de compuestos imidos inmunomoduladores para uso parenteral. | |
EP2785707A1 (en) | Novel 2h-indazoles as ep2 receptor antagonists | |
PH12020551494A1 (en) | Substituted imidazolidin-2-one derivatives as prmt5 inhibitors | |
MX2022010219A (es) | Compuestos heterociclicos de heteroarilo y usos de los mismos. | |
MX2022000598A (es) | Preparacion de compuestos antibacterianos. |