MX2023007495A - Un sistema para almacenar o cultivar un modelo de organo o tejido y sus usos. - Google Patents

Un sistema para almacenar o cultivar un modelo de organo o tejido y sus usos.

Info

Publication number
MX2023007495A
MX2023007495A MX2023007495A MX2023007495A MX2023007495A MX 2023007495 A MX2023007495 A MX 2023007495A MX 2023007495 A MX2023007495 A MX 2023007495A MX 2023007495 A MX2023007495 A MX 2023007495A MX 2023007495 A MX2023007495 A MX 2023007495A
Authority
MX
Mexico
Prior art keywords
perfusion fluid
measuring
organ
tissue model
cultivating
Prior art date
Application number
MX2023007495A
Other languages
English (en)
Inventor
Michal Wszola
Marta Klak
Andrzej Berman
Tomasz Dobrzanski
Igor Zamora
Dawid Kubinkiewicz
Mateusz Szczygielski
Original Assignee
Polbionica Sp Z O O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polbionica Sp Z O O filed Critical Polbionica Sp Z O O
Publication of MX2023007495A publication Critical patent/MX2023007495A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La invención se refiere a un sistema para almacenar o cultivar un modelo de órgano o tejido, y a un uso del mismo. El sistema está diseñado para verificar el funcionamiento de un órgano extraído o un modelo de tejido y permite tratarlo. El sistema se puede utilizar para cultivar órganos o modelos de tejido extraídos de donantes y/o producidos mediante otras técnicas, como el uso de bioimpresión 3D y/o 4D o tecnología de electrohilado, y comprende: una cámara (2) para el modelo de órgano o tejido equipado con medios para medir y ajustar la temperatura del fluido de perfusión en la cámara; un contenedor de fluido de perfusión (1) equipado con medios para medir y ajustar la temperatura del fluido de perfusión en su interior; medios (4) para medir la concentración de glucosa en el fluido de perfusión y para dosificar glucosa en el fluido de perfusión; medios (3) para medir el pH del fluido de perfusión y para dosificar sustancia para ajustar el pH del fluido de perfusión; medios para mezclar sin contacto el fluido de perfusión; y medios para medir y controlar los parámetros de flujo del fluido de perfusión.
MX2023007495A 2020-12-22 2021-12-22 Un sistema para almacenar o cultivar un modelo de organo o tejido y sus usos. MX2023007495A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20461600 2020-12-22
PCT/IB2021/062190 WO2022137164A1 (en) 2020-12-22 2021-12-22 A system for storing or cultivating of an organ or tissue model and uses thereof

Publications (1)

Publication Number Publication Date
MX2023007495A true MX2023007495A (es) 2023-11-14

Family

ID=74586706

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023007495A MX2023007495A (es) 2020-12-22 2021-12-22 Un sistema para almacenar o cultivar un modelo de organo o tejido y sus usos.

Country Status (10)

Country Link
US (1) US20240032528A1 (es)
EP (1) EP4266880A1 (es)
JP (1) JP2024500116A (es)
KR (1) KR20230150785A (es)
CN (1) CN116685672A (es)
AU (1) AU2021405399A1 (es)
CA (1) CA3202658A1 (es)
IL (1) IL303964A (es)
MX (1) MX2023007495A (es)
WO (1) WO2022137164A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102625965B1 (ko) * 2023-09-20 2024-01-17 백명현 개별 제어가 가능한 보관함을 포함하는 3d 프린터

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029865A1 (en) 1995-03-27 1996-10-03 Organ, Inc. Organ evaluation and resuscitation device and method
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
EP1392113A1 (en) * 2001-05-04 2004-03-03 Breonics, Inc. Organ chamber for exsanguinous metabolic support system
WO2006118990A2 (en) 2005-04-29 2006-11-09 Transplan, Inc. Method and device for organ perfusion
GB2467645B (en) * 2007-07-06 2011-12-21 Univ London A method of proliferating human hepatocyte cells
US9320269B2 (en) * 2009-09-25 2016-04-26 John Brassil Organ preservation system
WO2015122363A1 (ja) * 2014-02-12 2015-08-20 オリンパス株式会社 疑似人体装置
EP3229588A4 (en) 2014-12-12 2019-03-13 Freed, Darren APPARATUS AND METHOD FOR ORGAN PERFUSION
WO2018127554A1 (en) * 2017-01-06 2018-07-12 Novahep Ab Methods of preparing bioengineered or bioprinted organ or tissue, and uses thereof
WO2019122351A1 (en) * 2017-12-22 2019-06-27 Cellink Ab Tissue-specific human bioinks for the physiological 3d-bioprinting of human tissues for in vitro culture and transplantation
CN110402921A (zh) * 2019-09-06 2019-11-05 临海迪萨智能技术有限公司 一种离体动物肝脏的常温携氧灌注装置

Also Published As

Publication number Publication date
WO2022137164A1 (en) 2022-06-30
IL303964A (en) 2023-08-01
KR20230150785A (ko) 2023-10-31
EP4266880A1 (en) 2023-11-01
AU2021405399A1 (en) 2023-07-06
US20240032528A1 (en) 2024-02-01
JP2024500116A (ja) 2024-01-04
CN116685672A (zh) 2023-09-01
CA3202658A1 (en) 2022-06-30
AU2021405399A9 (en) 2024-02-08

Similar Documents

Publication Publication Date Title
CN104005016A (zh) 一种兼具抗菌及促成骨细胞功能的医用钛合金及其制备方法
BRPI0516261A (pt) método para produzir uma substãncia básica por fermentação, e, caldo de fermentação ou produto de fermentação contendo uma substáncia básica
SG10201805199RA (en) Methods and Uses for Ex Vivo Tissue Culture Systems
EP2323725A4 (en) THERAPEUTIC DEVICE BASED ON EXTRACORPOREAL CELLS AND ADMINISTRATION SYSTEM
MX2023007495A (es) Un sistema para almacenar o cultivar un modelo de organo o tejido y sus usos.
US20200087603A1 (en) Bioreactor module, a bioreactor system and methods for thick tissue seeding and cultivation in an hierarchical organization and physiological mimicking conditions
Bueno-Beti et al. The Sugen 5416/hypoxia mouse model of pulmonary arterial hypertension
VanDemark et al. Factors affecting testicular metabolism and function
WO2011022045A3 (en) Apparatus and process for generating and harvesting adult stem cells and fluid associated with it from skin and omentum for medical, cosmetic, and veterinary use
Maschhoff et al. An intelligent bioreactor system for the cultivation of a bioartificial vascular graft
CN106085854B (zh) 一种基于血液透析器的细胞培养装置
CN104399122B (zh) 一种脱细胞基质及其制备方法
CN106563173A (zh) 一种脱细胞生物真皮材料及其制备方法和应用
US9289352B2 (en) Carbon dioxide gas mist pressure bath apparatus for improving or promoting circulation of blood in ischemic region of living organism
CN104031837A (zh) 一种具有生物培养功能的关节运动模拟测试系统
Abbatiello et al. Development of an In-House Customized Perfusion-Based Bioreactor for 3D Cell Culture
CN102010822A (zh) 细胞培养液雾化供应装置
Nagy et al. Effects of pulsed variable magnetic fields over plant seeds
KR20150041557A (ko) 미세기포를 이용하여 기능성 식물을 재배하는 방법 및 시스템
Nomura et al. CIII The Capillary in the Human Vestibular Labyrinth: A Histochemical Staining Technique
Dunpall et al. Development and characterization of MCF7 mammary carcinoma xenografts in a non-immunocompromised rat model
CN106085839B (zh) 一种基于血液透析器的细菌培养装置
CN104152404A (zh) 提高胚胎耐热性的培养液及其使用方法
CN209696054U (zh) 一种自动控制模拟生物体循环的磁靶向治疗装置
de Coo et al. Prolonged normothermic perfusion of the isolated bovine eye: initial results