MX2023007326A - Moleculas de fusion inmunomoduladoras localizadas por colageno lineales bifuncionales y metodos de las mismas. - Google Patents
Moleculas de fusion inmunomoduladoras localizadas por colageno lineales bifuncionales y metodos de las mismas.Info
- Publication number
- MX2023007326A MX2023007326A MX2023007326A MX2023007326A MX2023007326A MX 2023007326 A MX2023007326 A MX 2023007326A MX 2023007326 A MX2023007326 A MX 2023007326A MX 2023007326 A MX2023007326 A MX 2023007326A MX 2023007326 A MX2023007326 A MX 2023007326A
- Authority
- MX
- Mexico
- Prior art keywords
- collagen
- methods
- localized
- immunomodulatory molecules
- functional linear
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000004927 fusion Effects 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4725—Proteoglycans, e.g. aggreccan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063127995P | 2020-12-18 | 2020-12-18 | |
| PCT/US2021/064224 WO2022133326A1 (en) | 2020-12-18 | 2021-12-17 | Bi-functional linear fusion collagen-localized immunomodulatory molecules and methods thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023007326A true MX2023007326A (es) | 2023-08-22 |
Family
ID=82058332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023007326A MX2023007326A (es) | 2020-12-18 | 2021-12-17 | Moleculas de fusion inmunomoduladoras localizadas por colageno lineales bifuncionales y metodos de las mismas. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240101630A1 (https=) |
| EP (1) | EP4262840A4 (https=) |
| JP (1) | JP2024500870A (https=) |
| KR (1) | KR20230124633A (https=) |
| CN (1) | CN116887850A (https=) |
| AU (1) | AU2021400761A1 (https=) |
| CA (1) | CA3202397A1 (https=) |
| IL (1) | IL303712A (https=) |
| MX (1) | MX2023007326A (https=) |
| WO (1) | WO2022133326A1 (https=) |
| ZA (1) | ZA202306571B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019346335B2 (en) | 2018-09-28 | 2024-07-25 | Massachusetts Institute Of Technology | Collagen-localized immunomodulatory molecules and methods thereof |
| WO2025049528A1 (en) * | 2023-08-29 | 2025-03-06 | Cullinan Amber Corp. | Combination therapies for cancer |
| WO2025245169A1 (en) * | 2024-05-21 | 2025-11-27 | Fred Hutchinson Cancer Center | Immunotherapy cells equipped with a collagen-targeting payload |
| WO2025255560A1 (en) * | 2024-06-07 | 2025-12-11 | Rush University Medical Center | Intranasal p40 monomer and anti-p40 homodimer mab for type 1 diabetes |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007073661A1 (fr) * | 2005-12-26 | 2007-07-05 | Yantai Zhenghai Bio-Technology Co., Ltd. | Matieres de squelette de collagene activees et leurs facteurs speciaux de restauration active fusionnee |
| CA2957717C (en) * | 2014-08-12 | 2021-10-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2 and integrin-binding-fc-fusion protein |
| US12084495B2 (en) * | 2016-08-03 | 2024-09-10 | Nextcure, Inc. | Compositions and methods for modulating LAIR signal transduction |
| HUE070957T2 (hu) * | 2017-02-16 | 2025-07-28 | Sonnet Biotherapeutics Inc | Albuminkötõ domén fúziós fehérjék |
| AU2019232729B2 (en) * | 2018-03-05 | 2024-08-08 | The University Of Chicago | Methods and compositions for treating cancer with ECM-affinity peptides linked to cytokines |
| US10786438B2 (en) * | 2018-04-27 | 2020-09-29 | Krystal Biotech, Inc. | Recombinant nucleic acids encoding cosmetic protein(s) for aesthetic applications |
| AU2019271148B9 (en) * | 2018-05-14 | 2025-05-29 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| AU2019335014A1 (en) * | 2018-09-05 | 2021-03-25 | Poseida Therapeutics, Inc. | Allogeneic cell compositions and methods of use |
| CA3117961A1 (en) * | 2018-10-29 | 2020-05-07 | Spin Therapeutics, Llc | Compositions and methods for alpha-1-antitrypsin disorders |
| WO2020163264A1 (en) * | 2019-02-04 | 2020-08-13 | Neutrolis, Inc. | Engineered human extracellular dnase enzymes for drug candidate selection |
| WO2020186111A2 (en) * | 2019-03-12 | 2020-09-17 | xCella Biosciences, Inc. | Vista-binding antibodies and uses thereof |
-
2021
- 2021-12-17 US US18/257,177 patent/US20240101630A1/en active Pending
- 2021-12-17 JP JP2023537915A patent/JP2024500870A/ja active Pending
- 2021-12-17 AU AU2021400761A patent/AU2021400761A1/en active Pending
- 2021-12-17 EP EP21907967.0A patent/EP4262840A4/en active Pending
- 2021-12-17 MX MX2023007326A patent/MX2023007326A/es unknown
- 2021-12-17 KR KR1020237024345A patent/KR20230124633A/ko active Pending
- 2021-12-17 CN CN202180093757.8A patent/CN116887850A/zh active Pending
- 2021-12-17 WO PCT/US2021/064224 patent/WO2022133326A1/en not_active Ceased
- 2021-12-17 CA CA3202397A patent/CA3202397A1/en active Pending
- 2021-12-17 IL IL303712A patent/IL303712A/en unknown
-
2023
- 2023-06-26 ZA ZA2023/06571A patent/ZA202306571B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230124633A (ko) | 2023-08-25 |
| IL303712A (en) | 2023-08-01 |
| EP4262840A1 (en) | 2023-10-25 |
| CA3202397A1 (en) | 2022-06-23 |
| ZA202306571B (en) | 2024-11-27 |
| CN116887850A (zh) | 2023-10-13 |
| WO2022133326A1 (en) | 2022-06-23 |
| AU2021400761A1 (en) | 2023-07-06 |
| JP2024500870A (ja) | 2024-01-10 |
| US20240101630A1 (en) | 2024-03-28 |
| EP4262840A4 (en) | 2024-11-20 |
| AU2021400761A9 (en) | 2024-10-10 |
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