MX2023006002A - Derivados de heterociclo para tratar trastornos mediados por potencial de receptor transitorio melastatina (trpm3). - Google Patents

Derivados de heterociclo para tratar trastornos mediados por potencial de receptor transitorio melastatina (trpm3).

Info

Publication number
MX2023006002A
MX2023006002A MX2023006002A MX2023006002A MX2023006002A MX 2023006002 A MX2023006002 A MX 2023006002A MX 2023006002 A MX2023006002 A MX 2023006002A MX 2023006002 A MX2023006002 A MX 2023006002A MX 2023006002 A MX2023006002 A MX 2023006002A
Authority
MX
Mexico
Prior art keywords
trpm3
mediated disorders
treating
heterocycle derivatives
disorders
Prior art date
Application number
MX2023006002A
Other languages
English (en)
Inventor
Melanie Reich
Arnaud Marchand
Sara Allasia
Philippe Arzel
Patrick Chaltin
Amuri Kilonda
Jean-Christophe Vanherck
Thomas Voets
Joris Vriens
André Welbers
Original Assignee
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leuven Kath filed Critical Univ Leuven Kath
Publication of MX2023006002A publication Critical patent/MX2023006002A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a compuestos que son útiles para la prevención o el tratamiento de trastornos mediados por TRPM3, más particularmente trastornos seleccionados de dolor e hipersensibilidad inflamatoria. La invención también se refiere a un método para la prevención o el tratamiento de los trastornos mediados por TRPM3.
MX2023006002A 2020-11-24 2021-11-24 Derivados de heterociclo para tratar trastornos mediados por potencial de receptor transitorio melastatina (trpm3). MX2023006002A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20209574 2020-11-24
PCT/EP2021/082865 WO2022112352A1 (en) 2020-11-24 2021-11-24 Heterocycle derivatives for treating trpm3 mediated disorders

Publications (1)

Publication Number Publication Date
MX2023006002A true MX2023006002A (es) 2023-10-10

Family

ID=73597813

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023006002A MX2023006002A (es) 2020-11-24 2021-11-24 Derivados de heterociclo para tratar trastornos mediados por potencial de receptor transitorio melastatina (trpm3).

Country Status (11)

Country Link
US (1) US20240051949A1 (es)
EP (1) EP4251616A1 (es)
JP (1) JP2023553297A (es)
KR (1) KR20230124926A (es)
CN (1) CN116745283A (es)
AU (1) AU2021386627A1 (es)
CA (1) CA3199496A1 (es)
IL (1) IL304324A (es)
MX (1) MX2023006002A (es)
TW (1) TW202235072A (es)
WO (1) WO2022112352A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023230540A2 (en) * 2022-05-25 2023-11-30 Katholieke Universiteit Leuven Indazole derivatives for treating trpm3-mediated disorders
WO2023230542A2 (en) * 2022-05-25 2023-11-30 Katholieke Universiteit Leuven PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS
WO2023230543A1 (en) * 2022-05-25 2023-11-30 Katholieke Universiteit Leuven Indolizine derivatives for treating trpm3-mediated disorders
TW202411211A (zh) * 2022-05-25 2024-03-16 比利時魯汶大學 用於治療trpm3介導病症之新型衍生物
WO2024013052A1 (en) 2022-07-13 2024-01-18 Glaxosmithkline Intellectual Property (No.3) Limited Novel use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
US11384071B2 (en) * 2016-12-07 2022-07-12 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft Inhibitors of mechanotransduction to treat pain and modulate touch perception

Also Published As

Publication number Publication date
KR20230124926A (ko) 2023-08-28
CA3199496A1 (en) 2022-06-02
CN116745283A (zh) 2023-09-12
IL304324A (en) 2023-09-01
WO2022112352A1 (en) 2022-06-02
US20240051949A1 (en) 2024-02-15
EP4251616A1 (en) 2023-10-04
AU2021386627A1 (en) 2023-06-22
TW202235072A (zh) 2022-09-16
JP2023553297A (ja) 2023-12-21

Similar Documents

Publication Publication Date Title
MX2023006002A (es) Derivados de heterociclo para tratar trastornos mediados por potencial de receptor transitorio melastatina (trpm3).
MX2023006003A (es) Derivados de arilo para tratar trastornos mediados por el canal catiónico de potencial de receptor transitorio subfamilia m miembro 3 (trpm3).
JOP20220245A1 (ar) أجسام مضادة ترتبط تحديداً بـ masp-3 لعلاج أمراض واضطرابات متنوعة
MX2018012655A (es) Compuestos y metodos para tratamiento de afecciones neurologicas y cardiovasculares.
MX2021010888A (es) Derivados heteroaromaticos y aromaticos heterobiciclicos para el tratamiento de trastornos relacionados con ferroptosis.
PH12020551071A1 (en) Compositions and methods for treating retinal disorders
EP3681477A4 (en) IMPROVED METHOD AND COMPOSITION FOR THE TREATMENT OF CONDITIONS, DISEASES OR DISORDERS SENSITIVE TO TRITERPENES
AU2017277478A1 (en) Pharmaceutical combinations for treating cancer
MX2020011344A (es) Métodos para tratar tumores en reposo suprarrenales testiculares y de ovarios.
IL279634A (en) Preparations and methods for the treatment and prevention of neurological disorders
MX2021002652A (es) Uso de inhibidores de caseina-cinasa 1 para el tratamiento de enfermedades vasculares.
EP3649861A4 (en) METHOD FOR TREATMENT OF THE SURFACE OF COPPER OR A COPPER ALLOY, SURFACE TREATMENT LIQUID FOR STERILIZATION OF COPPER OR OF A COPPER ALLOY, AND STERILIZATION METHODS WITH COPPER OR A COPPER ALLOY THAT COMES WITH
IL311852A (en) Preparations and methods for the treatment of neurological disorders
MX2021000908A (es) Tratamiento de la tos cronica, la dificultad respiratoria y la disnea.
WO2023230540A3 (en) Indazole derivatives for treating trpm3-mediated disorders
EP4103177A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT AND/OR PREVENTION OF EYE DISEASES
MX2022003720A (es) Un metodo para tratar los trastornos del estado de animo.
EP4136103A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISEASES
MX2022016179A (es) Compuestos y metodos para tratar infecciones fungicas.
WO2021136841A3 (fr) Composition pharmaceutique pour la prevention ou le traitement des douleurs post-operatoires
EP4076429A4 (en) COMPOSITIONS AND METHODS FOR TREATING NEUROMUSCULAR DISORDERS
EP4041390A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF HEAD TRAUMA
WO2020097442A3 (en) Compositions and methods for the treatment of peripheral artery disease and cardiopulmonary diseases
HUE064942T2 (hu) Kezelõrendszer és eljárás munkadarabok kezeléséhez
MX2021001393A (es) Composiciones para el tratamiento de la enfermedad de injerto contra huesped.