MX2023004899A - Direccionamiento de src-3 en celulas inmunitarias como un inmunomodulador terapeutico para el tratamiento de cancer. - Google Patents

Direccionamiento de src-3 en celulas inmunitarias como un inmunomodulador terapeutico para el tratamiento de cancer.

Info

Publication number
MX2023004899A
MX2023004899A MX2023004899A MX2023004899A MX2023004899A MX 2023004899 A MX2023004899 A MX 2023004899A MX 2023004899 A MX2023004899 A MX 2023004899A MX 2023004899 A MX2023004899 A MX 2023004899A MX 2023004899 A MX2023004899 A MX 2023004899A
Authority
MX
Mexico
Prior art keywords
src
cells
targeting
cancer
immune cells
Prior art date
Application number
MX2023004899A
Other languages
English (en)
Inventor
Bert W O''malley
Sang Jun Han
David M Lonard
Bryan Nikolai
Prashi Jain
Yosef Gilad
Clifford Dacso
Original Assignee
Baylor College Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College Medicine filed Critical Baylor College Medicine
Publication of MX2023004899A publication Critical patent/MX2023004899A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/49—Breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente divulgación se refiere a métodos y composiciones relacionadas con el tratamiento del cáncer que comprenden el direccionamiento de SRC-3 en células inmunitarias, incluidas las células T tales como las células T reguladoras. El direccionamiento de SRC-3 en células T reguladoras en particular es efectivo para erradicar tumores en mamíferos. En casos específicos, las células T reguladoras se someten a CRISPR ex-vivo para producir células adecuadas para la transferencia celular adoptiva. En algunos casos, también se administran al individuo uno o más agentes que se dirigen a SRC-3 y/o se exponen a las células antes de la administración.
MX2023004899A 2020-10-28 2021-08-27 Direccionamiento de src-3 en celulas inmunitarias como un inmunomodulador terapeutico para el tratamiento de cancer. MX2023004899A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063106770P 2020-10-28 2020-10-28
PCT/US2021/071302 WO2022094501A1 (en) 2020-10-28 2021-08-27 Targeting of src-3 in immune cells as an immunomodulatory therapeutic for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2023004899A true MX2023004899A (es) 2023-07-18

Family

ID=81258866

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023004899A MX2023004899A (es) 2020-10-28 2021-08-27 Direccionamiento de src-3 en celulas inmunitarias como un inmunomodulador terapeutico para el tratamiento de cancer.

Country Status (10)

Country Link
US (4) US11497772B2 (es)
EP (1) EP4237096A1 (es)
JP (1) JP2023549674A (es)
KR (1) KR20230093329A (es)
CN (1) CN116600818A (es)
AU (1) AU2021372270A1 (es)
CA (1) CA3199761A1 (es)
IL (1) IL302316A (es)
MX (1) MX2023004899A (es)
WO (1) WO2022094501A1 (es)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1801099A (en) 1997-12-22 1999-07-12 American Home Products Corporation Nucleic acid sequences encoding nuclear receptor coactivator proteins and uses thereof
US6156571A (en) 1999-11-15 2000-12-05 Isis Pharmaceuticals Inc. Antisense inhibition of SRC-3 expression
US20030104975A1 (en) 2001-06-14 2003-06-05 Johan Auwerx Cofactor-based screening method for nuclear receptor modulators and related modulators
AU2002346049A1 (en) 2001-07-05 2003-01-21 Georgetown University Medical Center Coactivators in the diagnosis and treatment of breast cancer
US7097993B2 (en) 2003-06-25 2006-08-29 Wisconsin Alumni Research Foundation Method for identifying an agent that modulates type 1 phosphatidylinositol phosphate kinase isoform β661 activity
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
CA2772036A1 (en) 2009-08-24 2011-03-03 Phigenix, Inc. Targeting pax2 for the treatment of breast cancer
US8771693B2 (en) 2009-10-27 2014-07-08 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
US20130064881A1 (en) 2011-09-08 2013-03-14 Gradalis, Inc. Compositions and methods for treating prostate cancer
WO2013148824A1 (en) 2012-03-28 2013-10-03 Gradalis, Inc. METHODS AND COMPOSITIONS TO TREAT CANCER USING BIFUNCTIONAL SRC-3 shRNA
US20130266639A1 (en) 2012-03-28 2013-10-10 Baylor College Of Medicine METHODS FOR TREATING TRIPLE NEGATIVE BREAST CANCER USING BIFUNCTIONAL SRC 3 shRNA
DK3077544T3 (da) 2013-12-03 2019-07-08 Celestra Life Science Llc Rationelt-baseret design af en målrettet terapi til cancer
EP3134528A4 (en) 2014-04-25 2017-12-06 Strike Bio, Inc. Multiple targeted rnai for the treatment of cancers
CA2946407A1 (en) * 2014-04-25 2015-10-29 Strike Bio, Inc. Multiple targeted rnai for the treatment of cancers
WO2016109470A1 (en) 2014-12-30 2016-07-07 Baylor College Of Medicine Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer
WO2016109471A1 (en) 2014-12-30 2016-07-07 Baylor College Of Medicine Bufalin phosphate prodrugs and methods of use thereof
SG11201804038VA (en) 2016-01-08 2018-06-28 Univ California Conditionally active heterodimeric polypeptides and methods of use thereof
AU2017246476B2 (en) 2016-04-08 2021-08-05 Baylor College Of Medicine Small molecule regulators of steroid receptor coactivators and methods of use thereof
US20180203017A1 (en) 2016-12-30 2018-07-19 The Board Of Trustees Of The Leland Stanford Junior University Protein-protein interaction detection systems and methods of use thereof
CN107299133A (zh) 2017-06-09 2017-10-27 上海长海医院 一种前列腺癌的标志物spop及其在指导肿瘤治疗中的应用
CA3110839A1 (en) 2018-08-29 2020-03-05 Baylor College Of Medicine Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents
WO2021055517A1 (en) 2019-09-16 2021-03-25 The Board Of Trustees Of The Leland Stanford Junior University Methods of treatments based upon molecular characterization of breast cancer

Also Published As

Publication number Publication date
CA3199761A1 (en) 2022-05-05
KR20230093329A (ko) 2023-06-27
US11633428B2 (en) 2023-04-25
US11633429B2 (en) 2023-04-25
US20220160773A1 (en) 2022-05-26
IL302316A (en) 2023-06-01
CN116600818A (zh) 2023-08-15
EP4237096A1 (en) 2023-09-06
AU2021372270A1 (en) 2023-06-22
WO2022094501A1 (en) 2022-05-05
US20230293587A1 (en) 2023-09-21
US20220160772A1 (en) 2022-05-26
US20220125842A1 (en) 2022-04-28
JP2023549674A (ja) 2023-11-29
US11497772B2 (en) 2022-11-15

Similar Documents

Publication Publication Date Title
Yahyapour et al. Reduction–oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics
Mortezaee et al. Metformin as a radiation modifier; implications to normal tissue protection and tumor sensitization
BRPI0809670A8 (pt) métodos para aumentar a produção de célula tronco, para aumentar o número de granulócitos em um indivíduo, para prevenir, tratar e aliviar a mielossupressão que resulta de uma terapia contra o câncer, para tratar uma condição em um indivíduo, para tratar neutropenia e trombocitopenia em um mamífero, para expandir células tronco hematopoiéticas em cultura, para aumentar a hematopoiese em um indivíduo, para aumentar o número de célulars progenitoras hematopoiéticas em um indivíduo, e para fornecer enxerto estável da medula óssea, e, forma de dosagem oral.
MX2021013830A (es) Inhibidores de ezh2 para tratar linfomas.
MX2019010725A (es) Metodos y composiciones para tratar canceres usando antisentido.
EP4140487A8 (en) Combination therapy for treating cancer
EA201490911A1 (ru) Способы лечения злокачественных опухолей с использованием пероральных составов аналогов цитидина
MX2017013142A (es) Terapia combinada para tratar cáncer.
Amini et al. Mechanisms for radioprotection by melatonin; can it be used as a radiation countermeasure?
Zhou et al. Secretions from hypochlorous acid-treated tumor cells delivered in a melittin hydrogel potentiate cancer immunotherapy
MX2021012961A (es) Conjugados de anticuerpo y farmaco de amatoxina y usos de los mismos.
Chen et al. Triptolide modulates tumour-colonisation and anti-tumour effect of attenuated Salmonella encoding DNase I
Rahimi et al. Sublethal concentration of H 2 O 2 enhances the protective effect of mesenchymal stem cells in rat model of spinal cord injury
Bui et al. Challenges and limitations of strategies to promote therapeutic potential of human mesenchymal stem cells for cell-based cardiac repair
Zhang et al. Preexisting antitumor immunity augments the antitumor effects of chemotherapy
Chen et al. Current status of intratumour microbiome in cancer and engineered exogenous microbiota as a promising therapeutic strategy
Yu et al. Obligate anaerobic Salmonella typhimurium strain YB1 treatment on xenograft tumor in immunocompetent mouse model
Zou et al. Implanted, Wireless, Self‐Powered Photodynamic Therapeutic Tablet Synergizes with Ferroptosis Inducer for Effective Cancer Treatment
Jin et al. New understanding of the low-dose radiation-induced hormesis
MX2021005169A (es) Metodos y composiciones para el tratamiento de carcinoma hepatocelular usando antisentido.
MX2023004899A (es) Direccionamiento de src-3 en celulas inmunitarias como un inmunomodulador terapeutico para el tratamiento de cancer.
CN106265760B (zh) 戈氏梭菌驯化株在制备放疗增敏剂中的应用
Crescenti et al. Radioprotection of sensitive rat tissues by oligoelements Se, Zn, Mn plus Lachesis muta venom
Delesa Overview of anticancer activity of lactic acid bacteria
MX2021005168A (es) Metodos y composiciones para el tratamiento de cancer de mama usando antisentido.