MX2023002039A - Terapia metabolica del cancer. - Google Patents

Terapia metabolica del cancer.

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Publication number
MX2023002039A
MX2023002039A MX2023002039A MX2023002039A MX2023002039A MX 2023002039 A MX2023002039 A MX 2023002039A MX 2023002039 A MX2023002039 A MX 2023002039A MX 2023002039 A MX2023002039 A MX 2023002039A MX 2023002039 A MX2023002039 A MX 2023002039A
Authority
MX
Mexico
Prior art keywords
levels
diets
methionine
equal
activities
Prior art date
Application number
MX2023002039A
Other languages
English (en)
Inventor
Miguel López-Lázaro
José Manuel Calderón-Montaño
Julio José Jiménez-Alonso
Emilio Guillén-Mancina
Victor Jiménez-González
Alfonso Mate-Barrero
María Concepción Pérez-Guerrero
Estefanía Burgos-Morón
Original Assignee
Aminovita S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aminovita S L filed Critical Aminovita S L
Publication of MX2023002039A publication Critical patent/MX2023002039A/es

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Abstract

El objetivo de la presente invención es cambiar el entorno metabólico normal de células cancerosas usando dietas artificiales en las que se manipulan los niveles y ratios de aminoácidos específicos y lípidos. Debido a sus alteraciones de ADN, las células cancerosas no serán capaces de adaptarse completamente al nuevo entorno metabólico, que reducirá su capacidad de supervivencia y su protección contra el sistema inmunitario. La presente invención proporciona composiciones de dieta artificial que inducen sorprendentes actividades antineoplásicas en modelos animales de cánceres metastásicos; estas actividades fueron superiores a las observadas en ratones que recibieron los tratamientos farmacológicos usados en pacientes con cáncer. La presente invención muestra que los niveles de metionina y leucina tienen un impacto importante sobre la actividad antineoplásica in vivo de las dietas. En todas las dietas activas, los niveles de metionina son inferiores o iguales a 0.6 % y los niveles de leucina son inferiores o iguales a 10 %, basado en el peso total de toda la composición seca.
MX2023002039A 2020-09-23 2020-09-23 Terapia metabolica del cancer. MX2023002039A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES2020/070571 WO2022064079A1 (es) 2020-09-23 2020-09-23 Terapia metabólica del cáncer

Publications (1)

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MX2023002039A true MX2023002039A (es) 2023-03-15

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