MX2023001448A - Compuestos de quinolina como moduladores selectivos y/o duales de los receptores del acido biliar y los receptores del cisteinil-leucotrieno. - Google Patents
Compuestos de quinolina como moduladores selectivos y/o duales de los receptores del acido biliar y los receptores del cisteinil-leucotrieno.Info
- Publication number
- MX2023001448A MX2023001448A MX2023001448A MX2023001448A MX2023001448A MX 2023001448 A MX2023001448 A MX 2023001448A MX 2023001448 A MX2023001448 A MX 2023001448A MX 2023001448 A MX2023001448 A MX 2023001448A MX 2023001448 A MX2023001448 A MX 2023001448A
- Authority
- MX
- Mexico
- Prior art keywords
- receptors
- bile acid
- cysteinyl
- leukotriene
- selective
- Prior art date
Links
- 102000017002 Bile acid receptors Human genes 0.000 title abstract 2
- 108070000005 Bile acid receptors Proteins 0.000 title abstract 2
- 230000009977 dual effect Effects 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 102000010918 Cysteinyl leukotriene receptors Human genes 0.000 abstract 2
- 108050001116 Cysteinyl leukotriene receptors Proteins 0.000 abstract 2
- 102100038495 Bile acid receptor Human genes 0.000 abstract 1
- 102100025353 G-protein coupled bile acid receptor 1 Human genes 0.000 abstract 1
- 101000603876 Homo sapiens Bile acid receptor Proteins 0.000 abstract 1
- 101000857733 Homo sapiens G-protein coupled bile acid receptor 1 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con compuestos de la fórmula (I), sus composiciones farmacéuticas y usos, en particular, para el tratamiento y/o prevención de las enfermedades mediadas por los receptores del ácido biliar, FXR y GPBAR1, los receptores del cisteinil-leucotrieno (CysLTR). (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT202000019210 | 2020-08-04 | ||
| PCT/IB2021/057131 WO2022029640A1 (en) | 2020-08-04 | 2021-08-04 | Quinoline compounds as selective and/or dual modulators of bile acid receptors and leukotriene cysteinyl receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023001448A true MX2023001448A (es) | 2023-06-22 |
Family
ID=73005665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023001448A MX2023001448A (es) | 2020-08-04 | 2021-08-04 | Compuestos de quinolina como moduladores selectivos y/o duales de los receptores del acido biliar y los receptores del cisteinil-leucotrieno. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230357159A1 (es) |
| EP (1) | EP4192815A1 (es) |
| JP (1) | JP2023539034A (es) |
| KR (1) | KR20230066341A (es) |
| CN (1) | CN116323560A (es) |
| BR (1) | BR112023002159A2 (es) |
| CA (1) | CA3187998A1 (es) |
| MX (1) | MX2023001448A (es) |
| WO (1) | WO2022029640A1 (es) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4794188A (en) * | 1982-12-01 | 1988-12-27 | Usv Pharmaceutical Corporation | Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity |
| US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| JP2001520193A (ja) * | 1997-10-17 | 2001-10-30 | アヴェンティス ファーマシューティカルズ プロダクツ インコーポレイテッド | キノリン誘導体の治療的使用 |
| RU2011102587A (ru) * | 2008-06-25 | 2012-07-27 | Энвиво Фармасьютикалз, Инк. (Us) | Дизамещенные фенильные соединения |
-
2021
- 2021-08-04 CA CA3187998A patent/CA3187998A1/en active Pending
- 2021-08-04 EP EP21765705.5A patent/EP4192815A1/en active Pending
- 2021-08-04 US US18/019,711 patent/US20230357159A1/en active Pending
- 2021-08-04 WO PCT/IB2021/057131 patent/WO2022029640A1/en unknown
- 2021-08-04 MX MX2023001448A patent/MX2023001448A/es unknown
- 2021-08-04 CN CN202180068308.8A patent/CN116323560A/zh active Pending
- 2021-08-04 KR KR1020237007773A patent/KR20230066341A/ko unknown
- 2021-08-04 BR BR112023002159A patent/BR112023002159A2/pt unknown
- 2021-08-04 JP JP2023508081A patent/JP2023539034A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022029640A1 (en) | 2022-02-10 |
| CN116323560A (zh) | 2023-06-23 |
| JP2023539034A (ja) | 2023-09-13 |
| KR20230066341A (ko) | 2023-05-15 |
| BR112023002159A2 (pt) | 2023-04-25 |
| EP4192815A1 (en) | 2023-06-14 |
| CA3187998A1 (en) | 2022-02-10 |
| US20230357159A1 (en) | 2023-11-09 |
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