MX2022013649A - Métodos para identificar moduladores de la ruta de il-17. - Google Patents
Métodos para identificar moduladores de la ruta de il-17.Info
- Publication number
- MX2022013649A MX2022013649A MX2022013649A MX2022013649A MX2022013649A MX 2022013649 A MX2022013649 A MX 2022013649A MX 2022013649 A MX2022013649 A MX 2022013649A MX 2022013649 A MX2022013649 A MX 2022013649A MX 2022013649 A MX2022013649 A MX 2022013649A
- Authority
- MX
- Mexico
- Prior art keywords
- pathway
- methods
- detecting
- identifying modulators
- modulate
- Prior art date
Links
- 230000037361 pathway Effects 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000013691 Interleukin-17 Human genes 0.000 abstract 3
- 108050003558 Interleukin-17 Proteins 0.000 abstract 3
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 abstract 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Transmitters (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Se describen métodos para identificar agentes que modulan la ruta de interleucina-17 (IL-17). Dichos métodos usan la detección de un nivel de factor estimulante de colonias de granulocitos (G-CSF) en un sobrenadante celular y/o la detección de un nivel de expresión de un gen o un panel de genes de una célula tratada con un agente. También se describen sondas capaces de detectar un gen o panel de genes y kits para identificar agentes que modulan la ruta de IL-17.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063017960P | 2020-04-30 | 2020-04-30 | |
PCT/IB2021/053516 WO2021220182A1 (en) | 2020-04-30 | 2021-04-28 | Methods of identifying modulators of the il-17 pathway |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022013649A true MX2022013649A (es) | 2023-02-01 |
Family
ID=75787156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022013649A MX2022013649A (es) | 2020-04-30 | 2021-04-28 | Métodos para identificar moduladores de la ruta de il-17. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20230167497A1 (es) |
EP (1) | EP4143342A1 (es) |
JP (1) | JP2023525234A (es) |
KR (1) | KR20230017211A (es) |
CN (1) | CN115735009A (es) |
CA (1) | CA3181418A1 (es) |
IL (1) | IL297689A (es) |
MX (1) | MX2022013649A (es) |
WO (1) | WO2021220182A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230019507A (ko) * | 2020-04-30 | 2023-02-08 | 얀센 파마슈티카 엔.브이. | Il-17의 조절제로서의 이미다조피리다진 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006214384A1 (en) * | 2005-02-14 | 2006-08-24 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of IL-17F in diagnosis and therapy of airway inflammation |
WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
BRPI0908312A2 (pt) * | 2008-05-05 | 2015-08-18 | Novimmune Sa | '' anticorpo monoclonal totalmente humano isolado, composição farmacêutica, método de alívio de um sintoma de uma indicação clínica e método de alívio de um sintoma de uma doença autoimune, distúrbio inflamatório ou distúrbio da proliferação celular'' |
US20140234330A1 (en) * | 2011-07-22 | 2014-08-21 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
US9284283B2 (en) | 2012-02-02 | 2016-03-15 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating IL-17 |
WO2016044189A1 (en) * | 2014-09-15 | 2016-03-24 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonist and il-17 binding antagonists |
-
2021
- 2021-04-28 CA CA3181418A patent/CA3181418A1/en active Pending
- 2021-04-28 MX MX2022013649A patent/MX2022013649A/es unknown
- 2021-04-28 KR KR1020227041942A patent/KR20230017211A/ko unknown
- 2021-04-28 IL IL297689A patent/IL297689A/en unknown
- 2021-04-28 EP EP21723392.3A patent/EP4143342A1/en active Pending
- 2021-04-28 WO PCT/IB2021/053516 patent/WO2021220182A1/en unknown
- 2021-04-28 CN CN202180047214.2A patent/CN115735009A/zh active Pending
- 2021-04-28 US US17/997,435 patent/US20230167497A1/en active Pending
- 2021-04-28 JP JP2022565996A patent/JP2023525234A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20230017211A (ko) | 2023-02-03 |
CN115735009A (zh) | 2023-03-03 |
CA3181418A1 (en) | 2021-11-04 |
WO2021220182A1 (en) | 2021-11-04 |
JP2023525234A (ja) | 2023-06-15 |
US20230167497A1 (en) | 2023-06-01 |
EP4143342A1 (en) | 2023-03-08 |
IL297689A (en) | 2022-12-01 |
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