MX2022012823A - Polipéptidos modificados de il-12 e il-23 y usos de los mismos. - Google Patents
Polipéptidos modificados de il-12 e il-23 y usos de los mismos.Info
- Publication number
- MX2022012823A MX2022012823A MX2022012823A MX2022012823A MX2022012823A MX 2022012823 A MX2022012823 A MX 2022012823A MX 2022012823 A MX2022012823 A MX 2022012823A MX 2022012823 A MX2022012823 A MX 2022012823A MX 2022012823 A MX2022012823 A MX 2022012823A
- Authority
- MX
- Mexico
- Prior art keywords
- interleukin
- methods
- compositions
- signal transduction
- modulating
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 102000014158 Interleukin-12 Subunit p40 Human genes 0.000 abstract 3
- 108010011429 Interleukin-12 Subunit p40 Proteins 0.000 abstract 3
- 230000001404 mediated effect Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 230000019491 signal transduction Effects 0.000 abstract 2
- 102000013462 Interleukin-12 Human genes 0.000 abstract 1
- 108010065805 Interleukin-12 Proteins 0.000 abstract 1
- 102000013264 Interleukin-23 Human genes 0.000 abstract 1
- 108010065637 Interleukin-23 Proteins 0.000 abstract 1
- 229940117681 interleukin-12 Drugs 0.000 abstract 1
- 229940124829 interleukin-23 Drugs 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente descripción se refiere en general a composiciones y métodos para modular la transducción de señales mediada por interleucina-12 e interleucina-23. En particular, la descripción proporciona nuevas variantes de la subunidad p40 de interleucina-12 con afinidad de unión reducida a IL-12Rß1. También se proporcionan composiciones y métodos útiles para producir estas variantes de polipéptidos de IL-12p40, así como métodos para modular la señalización mediada por IL-12p40 y/o para el tratamiento de condiciones asociadas con perturbaciones de la transducción de señales mediada por IL-12p40.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063011742P | 2020-04-17 | 2020-04-17 | |
| US202163150451P | 2021-02-17 | 2021-02-17 | |
| PCT/US2021/027838 WO2021212083A2 (en) | 2020-04-17 | 2021-04-16 | Engineered il-12 and il-23 polypeptides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022012823A true MX2022012823A (es) | 2023-01-04 |
Family
ID=78084508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022012823A MX2022012823A (es) | 2020-04-17 | 2021-04-16 | Polipéptidos modificados de il-12 e il-23 y usos de los mismos. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230220031A1 (es) |
| EP (1) | EP4135780A4 (es) |
| JP (1) | JP2023521870A (es) |
| KR (1) | KR20230004646A (es) |
| CN (1) | CN115916261A (es) |
| AU (1) | AU2021255736A1 (es) |
| BR (1) | BR112022020826A2 (es) |
| CA (1) | CA3180340A1 (es) |
| IL (1) | IL297186A (es) |
| MX (1) | MX2022012823A (es) |
| WO (1) | WO2021212083A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2023007607A (es) * | 2020-12-23 | 2023-07-11 | Immunowake Inc | Inmunocitocinas y usos de estas. |
| TW202321282A (zh) * | 2021-07-19 | 2023-06-01 | 美商再生元醫藥公司 | Il12受體促效劑及其使用方法 |
| WO2024006563A1 (en) * | 2022-07-01 | 2024-01-04 | Sutro Biopharma, Inc. | Il-12 mutants with reduced toxicity, compositions thereof and methods of using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5573764A (en) * | 1994-01-21 | 1996-11-12 | Genetics Institute, Inc. | Use of interleukin-12 to prevent graft versus host disease |
| TWI357336B (en) * | 2003-03-10 | 2012-02-01 | Schering Corp | Uses of il-23 agonists and antagonists; related re |
| CA2962099A1 (en) * | 2014-09-22 | 2016-03-31 | Intrexon Corporation | Improved therapeutic control of heterodimeric and single chain forms of interleukin-12 |
| US10232053B2 (en) * | 2016-12-30 | 2019-03-19 | Trieza Therapeutics, Inc. | Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer |
-
2021
- 2021-04-16 AU AU2021255736A patent/AU2021255736A1/en active Pending
- 2021-04-16 EP EP21788055.8A patent/EP4135780A4/en active Pending
- 2021-04-16 JP JP2022562584A patent/JP2023521870A/ja active Pending
- 2021-04-16 KR KR1020227039989A patent/KR20230004646A/ko active Search and Examination
- 2021-04-16 MX MX2022012823A patent/MX2022012823A/es unknown
- 2021-04-16 IL IL297186A patent/IL297186A/en unknown
- 2021-04-16 US US17/995,986 patent/US20230220031A1/en active Pending
- 2021-04-16 CA CA3180340A patent/CA3180340A1/en active Pending
- 2021-04-16 CN CN202180041801.0A patent/CN115916261A/zh active Pending
- 2021-04-16 BR BR112022020826A patent/BR112022020826A2/pt unknown
- 2021-04-16 WO PCT/US2021/027838 patent/WO2021212083A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021255736A1 (en) | 2022-11-03 |
| BR112022020826A2 (pt) | 2022-11-29 |
| JP2023521870A (ja) | 2023-05-25 |
| IL297186A (en) | 2022-12-01 |
| WO2021212083A2 (en) | 2021-10-21 |
| WO2021212083A3 (en) | 2021-11-25 |
| EP4135780A4 (en) | 2024-06-05 |
| KR20230004646A (ko) | 2023-01-06 |
| US20230220031A1 (en) | 2023-07-13 |
| CN115916261A (zh) | 2023-04-04 |
| CA3180340A1 (en) | 2021-10-21 |
| EP4135780A2 (en) | 2023-02-22 |
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