MX2022011518A - Metodos para tratar deambulacion asociada a proteinopatia. - Google Patents
Metodos para tratar deambulacion asociada a proteinopatia.Info
- Publication number
- MX2022011518A MX2022011518A MX2022011518A MX2022011518A MX2022011518A MX 2022011518 A MX2022011518 A MX 2022011518A MX 2022011518 A MX2022011518 A MX 2022011518A MX 2022011518 A MX2022011518 A MX 2022011518A MX 2022011518 A MX2022011518 A MX 2022011518A
- Authority
- MX
- Mexico
- Prior art keywords
- proteinopathy
- wandering
- patients
- treating
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000003590 rho kinase inhibitor Substances 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- 201000011240 Frontotemporal dementia Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 206010029350 Neurotoxicity Diseases 0.000 abstract 1
- 206010044221 Toxic encephalopathy Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 208000029560 autism spectrum disease Diseases 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 230000007135 neurotoxicity Effects 0.000 abstract 1
- 231100000228 neurotoxicity Toxicity 0.000 abstract 1
- 230000007425 progressive decline Effects 0.000 abstract 1
- 230000004845 protein aggregation Effects 0.000 abstract 1
- 230000009529 traumatic brain injury Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se basa en el descubrimiento de que se pueden usar inhibidores de la quinasa rho para tratar la deambulación asociada a proteinopatía. Se cree que una cantidad de enfermedades neurológicas degenerativas son causadas, al menos en parte, por la formación de agregados de proteínas que provocan neurotoxicidad y deterioro progresivo de las funciones. Los métodos inventivos se refieren al uso de inhibidores de la quinasa rho para tratar a pacientes con deambulación asociada a proteinopatía. Los pacientes pueden padecer de enfermedad de Huntington, una lesión cerebral traumática, trastorno del espectro autista, síndrome de Down o una demencia asociada a proteinopatía, tal como enfermedad de Alzheimer o demencia frontotemporal.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062994527P | 2020-03-25 | 2020-03-25 | |
| US202063005913P | 2020-04-06 | 2020-04-06 | |
| PCT/US2021/012587 WO2021194608A1 (en) | 2020-03-25 | 2021-01-08 | Methods of treating proteinopathy- associated wandering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022011518A true MX2022011518A (es) | 2022-10-07 |
Family
ID=77855102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022011518A MX2022011518A (es) | 2020-03-25 | 2021-01-08 | Metodos para tratar deambulacion asociada a proteinopatia. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11642352B2 (es) |
| EP (1) | EP4125879A4 (es) |
| JP (1) | JP2023518707A (es) |
| CN (1) | CN115916187A (es) |
| CA (1) | CA3170073A1 (es) |
| MX (1) | MX2022011518A (es) |
| WO (1) | WO2021194608A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023509970A (ja) * | 2020-01-09 | 2023-03-10 | ウールジー・ファーマシューティカルズ・インコーポレイテッド | 皮質性認知症に関連する徘徊を治療する方法 |
| CN115996728A (zh) * | 2020-04-23 | 2023-04-21 | 乌尔塞制药公司 | 利用Rho激酶抑制剂治疗阿尔茨海默病的方法 |
| CA3236338A1 (en) * | 2021-11-12 | 2023-05-19 | Woolsey Pharmaceuticals, Inc. | Method of treating amyotrophic lateral sclerosis and dosing regimen for same |
| CA3236462A1 (en) | 2021-11-29 | 2023-06-01 | Woolsey Pharmaceuticals, Inc. | Methods of treating agitation and other dementia-associated behavioral symptoms |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3464012B2 (ja) | 1993-04-05 | 2003-11-05 | 旭化成株式会社 | 精神症候治療剤 |
| JP4260370B2 (ja) * | 1998-08-10 | 2009-04-30 | 旭化成ファーマ株式会社 | 塩酸ファスジルの経口徐放性製剤 |
| WO2005117896A1 (de) | 2004-06-03 | 2005-12-15 | Schering Aktiengesellschaft | Formulierungen, die fasudil, eine matrix und einem mantel enthalten |
| US20090318485A1 (en) * | 2006-07-20 | 2009-12-24 | Kalypsys, Inc. | Novel inhibitors of rho kinase |
| AU2007281701A1 (en) | 2006-08-10 | 2008-02-14 | Translational Genomics Research Institute | Compounds for improving learning and memory |
| US20080044390A1 (en) | 2006-08-11 | 2008-02-21 | Xiaowei Jin | Methods and compositions for the treatment of neurodegenerative disorders |
| EP2296472A4 (en) | 2008-05-12 | 2011-06-08 | Amnestix Inc | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR LEARNING AND REMINDERING IMPROVEMENT |
| CN101612157A (zh) | 2008-06-26 | 2009-12-30 | 天津红日药业股份有限公司 | 法舒地尔诱导成年脑内源性神经干细胞再生的用途 |
| ES2644238T3 (es) | 2012-03-12 | 2017-11-28 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin | Inhibidores de rho-quinasas para uso en el tratamiento de la esclerosis lateral amiotrófica |
| WO2017195224A1 (en) | 2016-05-09 | 2017-11-16 | Istituto Superiore Di Sanita' | Rho gtpase activating bacterial toxins for use in the treatment of disorders of the central nervous system by mucosal administration |
| JP2023509970A (ja) * | 2020-01-09 | 2023-03-10 | ウールジー・ファーマシューティカルズ・インコーポレイテッド | 皮質性認知症に関連する徘徊を治療する方法 |
| CN115996728A (zh) * | 2020-04-23 | 2023-04-21 | 乌尔塞制药公司 | 利用Rho激酶抑制剂治疗阿尔茨海默病的方法 |
| EP4181925A1 (en) * | 2020-07-14 | 2023-05-24 | Woolsey Pharmaceuticals, Inc. | Methods of treating proteinopathies |
-
2021
- 2021-01-08 EP EP21776897.7A patent/EP4125879A4/en active Pending
- 2021-01-08 MX MX2022011518A patent/MX2022011518A/es unknown
- 2021-01-08 WO PCT/US2021/012587 patent/WO2021194608A1/en unknown
- 2021-01-08 CN CN202180036165.2A patent/CN115916187A/zh active Pending
- 2021-01-08 US US17/144,802 patent/US11642352B2/en active Active
- 2021-01-08 CA CA3170073A patent/CA3170073A1/en active Pending
- 2021-01-08 JP JP2022554548A patent/JP2023518707A/ja active Pending
-
2023
- 2023-03-24 US US18/189,478 patent/US20230226073A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN115916187A (zh) | 2023-04-04 |
| US20210299140A1 (en) | 2021-09-30 |
| US11642352B2 (en) | 2023-05-09 |
| US20230226073A1 (en) | 2023-07-20 |
| WO2021194608A1 (en) | 2021-09-30 |
| EP4125879A1 (en) | 2023-02-08 |
| EP4125879A4 (en) | 2024-04-03 |
| CA3170073A1 (en) | 2021-09-30 |
| JP2023518707A (ja) | 2023-05-08 |
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