MX2022011291A - New recombinant lysin and its use in the treatment of gram-negative bacterial infections. - Google Patents
New recombinant lysin and its use in the treatment of gram-negative bacterial infections.Info
- Publication number
- MX2022011291A MX2022011291A MX2022011291A MX2022011291A MX2022011291A MX 2022011291 A MX2022011291 A MX 2022011291A MX 2022011291 A MX2022011291 A MX 2022011291A MX 2022011291 A MX2022011291 A MX 2022011291A MX 2022011291 A MX2022011291 A MX 2022011291A
- Authority
- MX
- Mexico
- Prior art keywords
- gram
- treatment
- new
- bacterial infections
- negative bacterial
- Prior art date
Links
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 title abstract 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title abstract 4
- 208000027096 gram-negative bacterial infections Diseases 0.000 title abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 238000013459 approach Methods 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01028—N-Acetylmuramoyl-L-alanine amidase (3.5.1.28)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
New recombinant lysin and its use in the treatment of gram-negative bacterial infections The present invention relates to a new recombinant lysin and its use as antimicrobial agent in new treatment approaches for eliminating antibiotic resistant Gram-negative bacteria, and minimizing the emergence of new resistances. It further concerns polynucleotides encoding the recombinant lysin of the invention, vectors and host cells comprising the same, as well as related methods, medical uses, compositions and kits.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20382177 | 2020-03-11 | ||
EP20382254 | 2020-03-31 | ||
PCT/EP2021/056264 WO2021180892A1 (en) | 2020-03-11 | 2021-03-11 | New recombinant lysin and its use in the treatment of gram-negative bacterial infections |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022011291A true MX2022011291A (en) | 2022-12-08 |
Family
ID=74859480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022011291A MX2022011291A (en) | 2020-03-11 | 2021-03-11 | New recombinant lysin and its use in the treatment of gram-negative bacterial infections. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20230138922A1 (en) |
EP (1) | EP4118192A1 (en) |
JP (1) | JP2023517245A (en) |
CN (1) | CN115605587A (en) |
AU (1) | AU2021236351A1 (en) |
CA (1) | CA3175024A1 (en) |
MX (1) | MX2022011291A (en) |
WO (1) | WO2021180892A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023139605A1 (en) * | 2022-01-20 | 2023-07-27 | Techinvention Lifecare Pvt. Ltd. | Lysin polypeptides and compositions thereof against urinary tract infection caused by drug-resistant gram- negative bacteria |
CN114774391B (en) * | 2022-03-09 | 2023-03-14 | 华南农业大学 | Bacteriophage lysin for resisting escherichia coli and application thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010002959A2 (en) * | 2008-07-03 | 2010-01-07 | The Rockefeller University | A chimeric bacteriophage lysin with activity against staphylococci bacteria |
KR20170024129A (en) | 2009-06-26 | 2017-03-06 | 카톨리에케 유니버시테이트 루벤 | Antimicrobial agents |
CN102575240B (en) | 2009-08-24 | 2016-01-13 | 勒芬天主教大学,K.U.勒芬R&D | new endolysin OBPgpLYS |
BR112016030580B1 (en) | 2014-06-26 | 2023-12-19 | The Rockefeller University | LYSINE POLYPEPTIDE AND POLYPEPTIDE FRAGMENT WITH ACTIVITY TO KILL GRAM-NEGATIVE BACTERIA |
CA2998484A1 (en) | 2015-09-17 | 2017-03-23 | Contrafect Corporation | Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby |
MX2019011808A (en) * | 2017-04-03 | 2020-01-09 | Sasinapas Co Ltd | Engineered gram-negative endolysins. |
-
2021
- 2021-03-11 CN CN202180034907.8A patent/CN115605587A/en active Pending
- 2021-03-11 MX MX2022011291A patent/MX2022011291A/en unknown
- 2021-03-11 CA CA3175024A patent/CA3175024A1/en active Pending
- 2021-03-11 US US17/910,688 patent/US20230138922A1/en active Pending
- 2021-03-11 JP JP2022554850A patent/JP2023517245A/en active Pending
- 2021-03-11 WO PCT/EP2021/056264 patent/WO2021180892A1/en unknown
- 2021-03-11 AU AU2021236351A patent/AU2021236351A1/en active Pending
- 2021-03-11 EP EP21710319.1A patent/EP4118192A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN115605587A (en) | 2023-01-13 |
JP2023517245A (en) | 2023-04-24 |
WO2021180892A1 (en) | 2021-09-16 |
AU2021236351A1 (en) | 2022-10-06 |
US20230138922A1 (en) | 2023-05-04 |
CA3175024A1 (en) | 2021-09-16 |
EP4118192A1 (en) | 2023-01-18 |
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