MX2022007810A - Derivado de amida novedoso util como inhibidor de diacilglicerol aciltransferasa 2, y uso del mismo. - Google Patents

Derivado de amida novedoso util como inhibidor de diacilglicerol aciltransferasa 2, y uso del mismo.

Info

Publication number
MX2022007810A
MX2022007810A MX2022007810A MX2022007810A MX2022007810A MX 2022007810 A MX2022007810 A MX 2022007810A MX 2022007810 A MX2022007810 A MX 2022007810A MX 2022007810 A MX2022007810 A MX 2022007810A MX 2022007810 A MX2022007810 A MX 2022007810A
Authority
MX
Mexico
Prior art keywords
inhibitor
amide derivative
diacylglycerol acyltransferase
derivative useful
novel amide
Prior art date
Application number
MX2022007810A
Other languages
English (en)
Inventor
Seung Hyun Yoon
Hyun Woo Joo
Bo Kyung Seo
Eun Jin Lee
Jin Young Jung
Su Young Yoon
Woo Young Cho
Young Shin Kwak
Min Mi Jo
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of MX2022007810A publication Critical patent/MX2022007810A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a un compuesto derivado de amida, que exhibe la actividad de un inhibidor de diacilglicerol aciltransferasa (DGAT) 2 y se representa por la fórmula química (1), una composición farmacéutica que comprende el mismo como un ingrediente activo y un uso del mismo.
MX2022007810A 2019-12-23 2020-12-22 Derivado de amida novedoso util como inhibidor de diacilglicerol aciltransferasa 2, y uso del mismo. MX2022007810A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20190173456 2019-12-23
PCT/KR2020/018933 WO2021133038A1 (ko) 2019-12-23 2020-12-22 디아실글리세롤 아실트랜스퍼라제 2 억제제로서 유용한 신규 아미드 유도체 및 이의 용도

Publications (1)

Publication Number Publication Date
MX2022007810A true MX2022007810A (es) 2022-07-19

Family

ID=76573186

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022007810A MX2022007810A (es) 2019-12-23 2020-12-22 Derivado de amida novedoso util como inhibidor de diacilglicerol aciltransferasa 2, y uso del mismo.

Country Status (12)

Country Link
US (1) US20230101389A1 (es)
EP (1) EP4074701B1 (es)
JP (1) JP7451017B2 (es)
KR (1) KR102557329B1 (es)
CN (1) CN114901653A (es)
AU (1) AU2020413583B2 (es)
BR (1) BR112022012352A2 (es)
CA (1) CA3161640A1 (es)
ES (1) ES2969310T3 (es)
MX (1) MX2022007810A (es)
WO (1) WO2021133038A1 (es)
ZA (1) ZA202208088B (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010022055A2 (en) 2008-08-20 2010-02-25 Amgen Inc. Inhibitors of voltage-gated sodium channels
WO2011031628A1 (en) 2009-09-14 2011-03-17 Schering Corporation Inhibitors of diacylglycerol acyltransferase
WO2012024179A1 (en) 2010-08-18 2012-02-23 Merck Sharp & Dohme Corp. Substituted amide derivatives as dgat-1 inhibitors
LT3119757T (lt) * 2014-03-17 2018-07-10 Pfizer Inc. Diacilglicerolio aciltransferazės 2 inhibitoriai, skirti panaudoti metabolinių ir susijusių ligų gydyme
AR109179A1 (es) * 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
PE20221630A1 (es) * 2019-12-23 2022-10-19 Lg Chemical Ltd Derivado de amino arilo novedoso util como inhibidor de diacilglicerol aciltransferasa 2 y uso del mismo
TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途

Also Published As

Publication number Publication date
CA3161640A1 (en) 2021-07-01
US20230101389A1 (en) 2023-03-30
BR112022012352A2 (pt) 2022-09-06
JP2023508969A (ja) 2023-03-06
WO2021133038A1 (ko) 2021-07-01
ES2969310T3 (es) 2024-05-17
ZA202208088B (en) 2024-03-27
EP4074701A1 (en) 2022-10-19
AU2020413583A1 (en) 2022-07-14
AU2020413583B2 (en) 2023-12-14
KR20210081285A (ko) 2021-07-01
JP7451017B2 (ja) 2024-03-18
EP4074701B1 (en) 2023-12-13
CN114901653A (zh) 2022-08-12
KR102557329B1 (ko) 2023-07-19
EP4074701A4 (en) 2023-01-11

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