MX2022005394A - Anticuerpos anti-ca ix humanizados y metodos de su uso. - Google Patents
Anticuerpos anti-ca ix humanizados y metodos de su uso.Info
- Publication number
- MX2022005394A MX2022005394A MX2022005394A MX2022005394A MX2022005394A MX 2022005394 A MX2022005394 A MX 2022005394A MX 2022005394 A MX2022005394 A MX 2022005394A MX 2022005394 A MX2022005394 A MX 2022005394A MX 2022005394 A MX2022005394 A MX 2022005394A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- hodgkin
- lymphoma
- cell lung
- leukemia
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 206010009944 Colon cancer Diseases 0.000 abstract 2
- 208000008839 Kidney Neoplasms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 2
- 206010038389 Renal cancer Diseases 0.000 abstract 2
- 201000010982 kidney cancer Diseases 0.000 abstract 2
- 208000003747 lymphoid leukemia Diseases 0.000 abstract 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010008342 Cervix carcinoma Diseases 0.000 abstract 1
- 208000005243 Chondrosarcoma Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 206010014733 Endometrial cancer Diseases 0.000 abstract 1
- 206010014759 Endometrial neoplasm Diseases 0.000 abstract 1
- 208000032612 Glial tumor Diseases 0.000 abstract 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 abstract 1
- 206010018338 Glioma Diseases 0.000 abstract 1
- 208000017604 Hodgkin disease Diseases 0.000 abstract 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 abstract 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 abstract 1
- 101000910338 Homo sapiens Carbonic anhydrase 9 Proteins 0.000 abstract 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 abstract 1
- 206010027406 Mesothelioma Diseases 0.000 abstract 1
- 208000034578 Multiple myelomas Diseases 0.000 abstract 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 abstract 1
- 206010029260 Neuroblastoma Diseases 0.000 abstract 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 206010041067 Small cell lung cancer Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 208000024770 Thyroid neoplasm Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010881 cervical cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- 201000010536 head and neck cancer Diseases 0.000 abstract 1
- 208000014829 head and neck neoplasm Diseases 0.000 abstract 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 201000000050 myeloid neoplasm Diseases 0.000 abstract 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 208000000587 small cell lung carcinoma Diseases 0.000 abstract 1
- 206010041823 squamous cell carcinoma Diseases 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 201000002510 thyroid cancer Diseases 0.000 abstract 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a un anticuerpo humanizado que reconoce específicamente el dominio proteoglicano de CA IX humana y a métodos terapéuticos y de diagnóstico que utilizan este anticuerpo. Los métodos se refieren, en términos particulares, al tratamiento o diagnóstico de tipos de cáncer seleccionados a partir de carcinoma de células escamosas, mieloma, cáncer pulmonar microcítico, cáncer pulmonar no microcítico, glioma, linfoma de hodgkiniano, linfoma no hodgkiniano, leucemia mieloide aguda, mieloma múltiple, cáncer (tracto)gastrointestinal, cáncer renal, cáncer ovárico, cáncer hepático, leucemia linfoblástica, leucemia linfocítica, cáncer colorrectal, cáncer endometrial, cáncer renal, cáncer prostático, cáncer tiroideo, melanoma, condrosarcoma, neuroblastoma, cáncer pancreático, glioblastoma multiforme, cáncer cervical, cáncer cerebral, cáncer estomacal, cáncer vesical, hepatoma, cáncer de mama, carcinoma de colon, mesotelioma y cáncer de cabeza y cuello.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2019/059492 WO2021090046A1 (en) | 2019-11-05 | 2019-11-05 | Humanized anti-ca ix antibodies and methods of their use |
| PCT/IB2020/060343 WO2021090187A1 (en) | 2019-11-05 | 2020-11-04 | Humanized anti-ca ix antibodies and methods of their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022005394A true MX2022005394A (es) | 2022-08-08 |
Family
ID=68654824
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022005332A MX2022005332A (es) | 2019-11-05 | 2019-11-05 | Anticuerpos anti-ca ix humanizados y metodos de su uso. |
| MX2022005394A MX2022005394A (es) | 2019-11-05 | 2020-11-04 | Anticuerpos anti-ca ix humanizados y metodos de su uso. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022005332A MX2022005332A (es) | 2019-11-05 | 2019-11-05 | Anticuerpos anti-ca ix humanizados y metodos de su uso. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20240150490A1 (es) |
| EP (2) | EP4055056A1 (es) |
| JP (2) | JP2023508826A (es) |
| AU (2) | AU2019472821A1 (es) |
| CA (2) | CA3156540A1 (es) |
| IL (2) | IL292413A (es) |
| MX (2) | MX2022005332A (es) |
| WO (2) | WO2021090046A1 (es) |
| ZA (1) | ZA202205341B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021090046A1 (en) * | 2019-11-05 | 2021-05-14 | Mabpro A.S. | Humanized anti-ca ix antibodies and methods of their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5387676A (en) | 1992-03-11 | 1995-02-07 | Ciba Corning Diagnostics Corp. | MN gene and protein |
| DK1487972T3 (en) | 2002-02-21 | 2015-10-19 | Inst Virology | MN / CA IX-specific monoclonal antibodies generated from MN / CA IX-poor mice, as well as methods of use. |
| AU2003223186A1 (en) | 2002-05-23 | 2004-01-23 | Bayer Healthcare | SOLUBLE FORM OF CARBONIC ANHYDRASE IX (s-CA IX), ASSAYS TO DETECT s-CA IX AND CA IX's COEXPRESSION WITH HER-2/neu/c-erbB-2 |
| WO2021090046A1 (en) | 2019-11-05 | 2021-05-14 | Mabpro A.S. | Humanized anti-ca ix antibodies and methods of their use |
-
2019
- 2019-11-05 WO PCT/IB2019/059492 patent/WO2021090046A1/en active Application Filing
- 2019-11-05 US US17/772,980 patent/US20240150490A1/en active Pending
- 2019-11-05 EP EP19808893.2A patent/EP4055056A1/en active Pending
- 2019-11-05 JP JP2022526425A patent/JP2023508826A/ja active Pending
- 2019-11-05 CA CA3156540A patent/CA3156540A1/en active Pending
- 2019-11-05 IL IL292413A patent/IL292413A/en unknown
- 2019-11-05 AU AU2019472821A patent/AU2019472821A1/en active Pending
- 2019-11-05 MX MX2022005332A patent/MX2022005332A/es unknown
-
2020
- 2020-11-04 EP EP20807885.7A patent/EP4055057A1/en active Pending
- 2020-11-04 US US17/774,111 patent/US20220396633A1/en active Pending
- 2020-11-04 JP JP2022526706A patent/JP7447255B2/ja active Active
- 2020-11-04 AU AU2020380627A patent/AU2020380627A1/en active Pending
- 2020-11-04 IL IL292634A patent/IL292634A/en unknown
- 2020-11-04 WO PCT/IB2020/060343 patent/WO2021090187A1/en active Application Filing
- 2020-11-04 CA CA3157048A patent/CA3157048A1/en active Pending
- 2020-11-04 MX MX2022005394A patent/MX2022005394A/es unknown
-
2022
- 2022-05-13 ZA ZA2022/05341A patent/ZA202205341B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL292634A (en) | 2022-07-01 |
| JP2023508826A (ja) | 2023-03-06 |
| EP4055057A1 (en) | 2022-09-14 |
| EP4055056A1 (en) | 2022-09-14 |
| ZA202205341B (en) | 2023-11-29 |
| CA3157048A1 (en) | 2021-05-14 |
| IL292413A (en) | 2022-06-01 |
| JP2023510075A (ja) | 2023-03-13 |
| JP7447255B2 (ja) | 2024-03-11 |
| WO2021090187A1 (en) | 2021-05-14 |
| AU2019472821A1 (en) | 2022-06-09 |
| AU2020380627A1 (en) | 2022-06-23 |
| US20240150490A1 (en) | 2024-05-09 |
| US20220396633A1 (en) | 2022-12-15 |
| MX2022005332A (es) | 2022-05-26 |
| WO2021090046A1 (en) | 2021-05-14 |
| CA3156540A1 (en) | 2021-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020055853A5 (es) | ||
| WO2016191246A3 (en) | T cell receptor-like antibodies specific for a prame peptide | |
| RU2014138038A (ru) | Фармацевтическая композиция для лечения профилактики рака | |
| BR112019010356A2 (pt) | molécula de carboidrato, conjugado fármaco-anticorpo (adc), composição, método para preparar a composição, método para tratar câncer em um indivíduo, método para induzir ou melhorar a reação imune em um indivíduo necessitando do mesmo, composto conjugado de fármaco-anticorpo, uso de um composto conjungado anticorpo-fáramco, método para determinar a eficácia terapêutica de células de câncer ao adcc e método para fazer imagem de um indivíduo | |
| JP2016187356A5 (es) | ||
| CY1120300T1 (el) | Αντισωματα ειδικα στην κλαουδινη 6 (cldn6) | |
| JP2018027952A5 (es) | ||
| RU2014138041A (ru) | Фармацевтическая композиция для лечения и/или профилактики рака | |
| RU2014138040A (ru) | Фармацевтическая композиция для лечения и/или профилактики рака | |
| HRP20180262T1 (hr) | Monoklonska anti-gt468 protutijela za liječenje karcinoma | |
| NZ607337A (en) | Antibodies for epidermal growth factor receptor 3 (her3) | |
| RU2014101669A (ru) | Агенты, связывающие белки r-спондины (rspo), и способы их применения | |
| RU2017138468A (ru) | Антитела против человеческого her3, имеющие низкое содержание фукозы, и области их применения | |
| MX2021005396A (es) | Anticuerpo anti-cd73, fragmento de union a antigeno y aplicacion del mismo. | |
| HRP20160212T1 (hr) | Antitijela za terapiju kancera koji eksprimira klaudin 6 | |
| MX2021015888A (es) | Fusión de un anticuerpo que se une a cea y 4-1bbl. | |
| NZ724368A (en) | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders | |
| RU2008152332A (ru) | Антитела, распознающие содержащий углеводы эпитоп на cd43 и сеа, экспрессируемых на злокачественных клетках, и способы их применения | |
| RU2014108044A (ru) | Фармацевтическая композиция для лечения и профилактики злокачественной опухоли | |
| RU2016107884A (ru) | Фармацевтическая композиция для лечения и/или профилактики рака | |
| HK1108163A1 (en) | Antibodies that bind to epha2 and methods of use thereof | |
| WO2016022939A8 (en) | Human monoclonal antibodies specific for 5t4 and methods of their use | |
| ZA202205341B (en) | Humanized anti-ca ix antibodies and methods of their use | |
| JP2018524300A5 (ja) | 組成物、抗体および結合性フラグメント | |
| MX2022009170A (es) | Procedimientos para el tratamiento del cancer con un anticuerpo antagonista anti-tigit. |