MX2022004817A - Monitorizacion de productos en linea en biofabricacion continua integrada. - Google Patents

Monitorizacion de productos en linea en biofabricacion continua integrada.

Info

Publication number
MX2022004817A
MX2022004817A MX2022004817A MX2022004817A MX2022004817A MX 2022004817 A MX2022004817 A MX 2022004817A MX 2022004817 A MX2022004817 A MX 2022004817A MX 2022004817 A MX2022004817 A MX 2022004817A MX 2022004817 A MX2022004817 A MX 2022004817A
Authority
MX
Mexico
Prior art keywords
fluid
manufacturing
angle
line product
product monitoring
Prior art date
Application number
MX2022004817A
Other languages
English (en)
Inventor
Robert Snow
Xuezhen Kang
Joseph P Kutzko
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MX2022004817A publication Critical patent/MX2022004817A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/4133—Refractometers, e.g. differential
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/4133—Refractometers, e.g. differential
    • G01N2021/4153—Measuring the deflection of light in refractometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N2021/8411—Application to online plant, process monitoring
    • G01N2021/8416—Application to online plant, process monitoring and process controlling, not otherwise provided for

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Computer Hardware Design (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

Los métodos para controlar un sistema de preparación biológica incluyen dirigir un haz de luz para que pase a través de una pared de un recipiente que contiene un primer fluido generado por el sistema de preparación biológica, medir un ángulo de refracción del haz de luz en el primer fluido, el ángulo de refracción correspondiente a un ángulo entre una dirección de propagación del haz de luz en el primer fluido y una normal a una interfaz entre la pared del recipiente y el primer fluido, determinando la información sobre el primer fluido en función del ángulo de refracción medido, y ajustando un parámetro del sistema de preparación biológica basado en la información sobre el primer fluido.
MX2022004817A 2019-10-22 2020-10-21 Monitorizacion de productos en linea en biofabricacion continua integrada. MX2022004817A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962924551P 2019-10-22 2019-10-22
PCT/US2020/056604 WO2021081055A1 (en) 2019-10-22 2020-10-21 In-line product monitoring in integrated continuous bio-manufacturing

Publications (1)

Publication Number Publication Date
MX2022004817A true MX2022004817A (es) 2022-06-16

Family

ID=73452281

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022004817A MX2022004817A (es) 2019-10-22 2020-10-21 Monitorizacion de productos en linea en biofabricacion continua integrada.

Country Status (12)

Country Link
US (1) US20210115385A1 (es)
EP (1) EP4049004A1 (es)
JP (1) JP2022553955A (es)
KR (1) KR20220082906A (es)
CN (1) CN114585723A (es)
AU (1) AU2020372397A1 (es)
BR (1) BR112022007525A2 (es)
CA (1) CA3155216A1 (es)
IL (1) IL292410A (es)
MX (1) MX2022004817A (es)
TW (1) TW202134631A (es)
WO (1) WO2021081055A1 (es)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0610297A1 (en) * 1991-09-30 1994-08-17 Perseptive Biosystems, Inc. Protein chromatography system
US8728479B2 (en) 2009-03-31 2014-05-20 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
AU2010351576B2 (en) * 2010-04-23 2014-08-14 FinaBioSolutions, LLC Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels
SG10201709131UA (en) 2013-03-08 2017-12-28 Genzyme Corp Continuous purification of therapeutic proteins
US10479973B2 (en) 2013-08-23 2019-11-19 Massachuesetts Institute Of Technology Small volume bioreactors with substantially constant working volumes and associated systems and methods
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
JP6953508B2 (ja) * 2016-04-04 2021-10-27 ベーリンガー インゲルハイム エルツェーファウ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 製剤精製のリアルタイムモニタリング
JP2017189123A (ja) * 2016-04-11 2017-10-19 オリンパス株式会社 試料観察装置
KR102465761B1 (ko) 2016-08-16 2022-11-09 젠자임 코포레이션 재조합 치료 단백질을 포함하는 유체의 처리 방법 및 상기 유체의 용도
CN112041663A (zh) * 2018-03-02 2020-12-04 建新公司 用于生物制造的多元谱分析与监测

Also Published As

Publication number Publication date
US20210115385A1 (en) 2021-04-22
JP2022553955A (ja) 2022-12-27
TW202134631A (zh) 2021-09-16
EP4049004A1 (en) 2022-08-31
BR112022007525A2 (pt) 2022-07-12
IL292410A (en) 2022-06-01
CA3155216A1 (en) 2021-04-29
KR20220082906A (ko) 2022-06-17
CN114585723A (zh) 2022-06-03
WO2021081055A1 (en) 2021-04-29
AU2020372397A1 (en) 2022-06-09

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