MX2022003399A - Cellular-based method for determining the potency of defibrotide. - Google Patents

Cellular-based method for determining the potency of defibrotide.

Info

Publication number
MX2022003399A
MX2022003399A MX2022003399A MX2022003399A MX2022003399A MX 2022003399 A MX2022003399 A MX 2022003399A MX 2022003399 A MX2022003399 A MX 2022003399A MX 2022003399 A MX2022003399 A MX 2022003399A MX 2022003399 A MX2022003399 A MX 2022003399A
Authority
MX
Mexico
Prior art keywords
defibrotide
potency
determining
cellular
based method
Prior art date
Application number
MX2022003399A
Other languages
Spanish (es)
Inventor
Vijay Kumar
Terenzio Ignoni
Claudio Verga
Original Assignee
Gentium S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52000693&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2022003399(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gentium S R L filed Critical Gentium S R L
Publication of MX2022003399A publication Critical patent/MX2022003399A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064—Endothelial cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to cell-based methods for determining the biological activity of defibrotide. In particular, the invention provides a method for assessing the potency of defibrotide by assessing the viability of mammalian cells in the presence of at least one cytotoxic agent and one or more concentrations of defibrotide. Such methods are particularly useful for standardizing pharmaceutical compositions comprising defibrotide.
MX2022003399A 2014-11-27 2017-05-26 Cellular-based method for determining the potency of defibrotide. MX2022003399A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14195277.0A EP3026122A1 (en) 2014-11-27 2014-11-27 Cellular-based method for determining the potency of defibrotide

Publications (1)

Publication Number Publication Date
MX2022003399A true MX2022003399A (en) 2022-04-18

Family

ID=52000693

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017006970A MX2017006970A (en) 2014-11-27 2015-11-23 Cellular-based method for determining the potency of defibrotide.
MX2022003399A MX2022003399A (en) 2014-11-27 2017-05-26 Cellular-based method for determining the potency of defibrotide.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017006970A MX2017006970A (en) 2014-11-27 2015-11-23 Cellular-based method for determining the potency of defibrotide.

Country Status (19)

Country Link
US (3) US10393731B2 (en)
EP (4) EP3026122A1 (en)
JP (3) JP6700276B2 (en)
KR (2) KR20220104070A (en)
CN (1) CN107109458B (en)
AU (2) AU2015352743B2 (en)
BR (1) BR112017011012B1 (en)
CA (1) CA2968608C (en)
DK (2) DK3120153T3 (en)
ES (2) ES2831834T3 (en)
FI (1) FI3748358T3 (en)
IL (2) IL252484B (en)
MX (2) MX2017006970A (en)
PL (1) PL3120153T3 (en)
PT (1) PT3120153T (en)
RU (1) RU2729628C2 (en)
SG (1) SG11201704015RA (en)
WO (1) WO2016083297A1 (en)
ZA (1) ZA201703385B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010363814B2 (en) 2010-11-12 2016-05-19 Gentium S.R.L. Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD).
KR20150044877A (en) 2012-06-22 2015-04-27 젠티엄 에스피에이 Euglobulin-based method for determining the biological activity of defibrotide
EP3026122A1 (en) * 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
CN111796086A (en) * 2020-07-03 2020-10-20 同济大学 Characterization method of acute and chronic dose-effect relationship of personal care product
WO2022234101A1 (en) 2021-05-06 2022-11-10 Jazz Pharmaceuticals Ireland Limited Defibrotide for the treatment and prevention of acute respiratory distress syndrome

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1043823B (en) 1970-11-03 1980-02-29 Prephar PROCEDURE FOR THE EXTRACTION OF NUCLEIC ACIDS FROM ANIMAL BODIES
DE2154279A1 (en) 1970-11-03 1972-05-25 Crinos Industria Farmaco Medicines for the fibrinolytic system
US3899481A (en) 1970-11-03 1975-08-12 Crinos Industria Farmaco Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
DE2812943C3 (en) 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Method and reagent for determining the biological activity of heparin in plasma
US4853221A (en) 1980-11-13 1989-08-01 Warner-Lambert Company Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
IT1170214B (en) 1983-09-12 1987-06-03 Crinos Industria Farmaco PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PERIPHERAL ARTERIOPATHIES
IT1170215B (en) 1983-09-12 1987-06-03 Crinos Industria Farmaco PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF STATES OF ACUTE RENAL INSUFFICIENCY
IT1206341B (en) 1984-02-16 1989-04-14 Crinos Industria Farmaco PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ACUTE MYOCARDIUM ISCHHEMIA.
US4694134A (en) 1985-05-28 1987-09-15 Ajax Magnethermic Corporation Apparatus for overheating edges of skelp for the production of compression welded pipe
US4693134A (en) 1985-06-20 1987-09-15 Excelermatic Inc. High-powered vehicle drive train
IT1190313B (en) 1986-04-17 1988-02-16 Crinos Industria Farmaco PROCEDURE FOR OBTAINING CHEMICALLY DEFINED AND REPRODUCIBLE POLYDOXYRIBONUCLEOTIDES AND THE PHARMACOLOGICALLY ACTIVE PRODUCT RESULT
US5223609A (en) 1986-04-17 1993-06-29 Crinos Industria Farmacobiologica S.P.A. Process for obtaining chemically defined and reproducible polydeoxyribonucleotides
US5231006A (en) 1986-10-16 1993-07-27 Behringwerke Aktiengesellschaft Method for the determination of plasminogen
US4753221A (en) 1986-10-22 1988-06-28 Intravascular Surgical Instruments, Inc. Blood pumping catheter and method of use
IT1223322B (en) 1987-10-23 1990-09-19 Crinos Industria Farmaco METHOD FOR PREVENTING THE FORMATION OF BLOOD CLOTS IN THE EXTRA-BODY CIRCUIT OF DIALYSIS EQUIPMENT USEFUL FOR IT
JP2907447B2 (en) 1988-08-24 1999-06-21 中外製薬株式会社 Antithrombotic agent
IT1231509B (en) 1989-09-07 1991-12-07 Crinos Industria Farmaco PHARMCEUTIC COMPOSITION FOR TOPICAL USE FOR THERAPY OF CAPILLARY FRAGILITY.
US5199942A (en) 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5624912A (en) 1991-08-21 1997-04-29 Burcoglu; Arsinur Method of treating HIV infection and related secondary infections with defibrotide
US6699985B2 (en) 1991-08-21 2004-03-02 Arsinur Burcoglu Method of treating HIV infection and related secondary infections thereof
US5977083A (en) 1991-08-21 1999-11-02 Burcoglu; Arsinur Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states
IT1252174B (en) 1991-12-09 1995-06-05 Crinos Industria Farmaco OLIGODESOXYBONUCLEOTIDES WITH ANTI-SCHEMICAL ACTIVITY AND PROCEDURES FOR THEIR OBTAINING
US5578716A (en) 1993-12-01 1996-11-26 Mcgill University DNA methyltransferase antisense oligonucleotides
JPH08127539A (en) 1994-10-31 1996-05-21 Ajinomoto Co Inc Human il-11-containing peripheral blood stem cell proliferator
EP0801076A4 (en) 1994-11-30 1999-12-15 Chugai Pharmaceutical Co Ltd Thrombocytotic factor
CA2260014A1 (en) 1996-07-10 1998-01-15 Meiji Milk Products Co., Ltd. Novel use of mk family as hematopoietic factor
WO1998048843A1 (en) 1997-04-28 1998-11-05 Arsinur Burcoglu Method of treating hiv infection and related secondary infections thereof
AU8125098A (en) 1997-05-30 1998-12-30 Mcgill University Dna methyltransferase genomic sequences and antisense oligonucleotides
US6177545B1 (en) 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
DE19740384A1 (en) 1997-09-08 1999-03-11 Max Delbrueck Centrum Antisense oligonucleotides specific for protein kinase C isoforms
GB9719161D0 (en) 1997-09-09 1997-11-12 Glaxo Group Ltd New therapeutic method
US6573372B2 (en) 1999-01-07 2003-06-03 Heska Corporation Feline immunoglobulin E molecules and compositions there of
IL146872A0 (en) 1999-06-03 2002-08-14 Methods and compositions for modulating cell proliferation and cell death
DK1059092T3 (en) 1999-06-08 2006-03-27 Gentium Spa Use of complexes of cationic liposomes and polydeoxyribonucleotides as drugs
US8771663B2 (en) 2000-04-18 2014-07-08 Gentium Spa Formulation having mobilising activity
EP1147777A1 (en) 2000-04-18 2001-10-24 Crinos Industria Farmacobiologica S.p.A. Combination of defibrotide and G-CSF and its use to activate haematopoietic progenitors
IL155450A0 (en) 2000-10-20 2003-11-23 Expression Diagnostics Inc Leukocyte expression profiling
DE60131569T2 (en) * 2000-11-28 2008-10-23 The University Of Chicago, Chicago GENETICALLY MODIFIED HERPES VIRUS FOR THE TREATMENT OF HEART AND VASCULAR DISEASES
HUP0700079A2 (en) 2000-12-29 2007-05-02 Savient Pharmaceuticals Isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6770753B2 (en) 2001-07-05 2004-08-03 The Trustees Of Columbia University In The City Of New York Phosphorothioate antisense heparanase oligonucleotides
WO2003027313A2 (en) 2001-09-24 2003-04-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
US6965025B2 (en) 2001-12-10 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of connective tissue growth factor expression
EP1325962A1 (en) * 2001-12-17 2003-07-09 Gentium S.p.A. A method for determining the biological activity of defibrotide
EP2284535A1 (en) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
RS102504A (en) 2002-05-31 2006-12-15 Universitat Regensburg Method for the protection of endothelial and epithelial cells during chemotherapy
US20050215498A1 (en) 2002-05-31 2005-09-29 Guenther Eissner Method for the protection of endothelial and epithclial cells during chemotherapy
CA2491363A1 (en) 2002-07-01 2004-01-08 Savient Pharmaceuticals, Inc. Antibodies and uses thereof
CA2501719C (en) 2002-08-06 2013-02-05 Toray Industries, Inc. Remedy or preventive for kidney disease and method of diagnosing kidney disease
US20050196382A1 (en) 2002-09-13 2005-09-08 Replicor, Inc. Antiviral oligonucleotides targeting viral families
DE10244453A1 (en) 2002-09-24 2004-04-01 Phenomiques Gmbh Inhibition of the protein kinase C-alpha for the treatment of diseases
US7803781B2 (en) 2003-02-28 2010-09-28 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
ITMI20031714A1 (en) * 2003-09-05 2005-03-06 Gentium Spa FORMATIONS FOR ANTITUMORAL ACTION.
US7723127B2 (en) * 2005-03-03 2010-05-25 Novx Systems Inc. Immunoassay with extended dynamic range
JP2008531647A (en) 2005-03-03 2008-08-14 ゲンチウム エスピーエー Formulation with antitumor activity
WO2006119619A1 (en) 2005-05-06 2006-11-16 Replicor Inc. Oligonucleotides inhibiting cell proliferation
EP1872787A1 (en) 2006-06-27 2008-01-02 Gentium S.p.A. Use of defibrotide for the inhibition of heparanase
EP1982722A1 (en) 2007-04-16 2008-10-22 Gentium S.p.A. Use of oligotide for the treatment of renal diseases
CA2692604A1 (en) * 2007-07-13 2009-01-22 Elan Pharmaceuticals, Inc. Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase
EP2103689A1 (en) 2008-03-19 2009-09-23 Gentium S.p.A. Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
JP2011522515A (en) * 2008-04-10 2011-08-04 マサチューセッツ インスティテュート オブ テクノロジー Methods for identifying drugs that target cancer stem cells and uses thereof
NZ624963A (en) 2009-04-29 2016-07-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AU2010363814B2 (en) 2010-11-12 2016-05-19 Gentium S.R.L. Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD).
KR20150044877A (en) * 2012-06-22 2015-04-27 젠티엄 에스피에이 Euglobulin-based method for determining the biological activity of defibrotide
EP3026122A1 (en) * 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide

Also Published As

Publication number Publication date
KR20220104070A (en) 2022-07-25
CA2968608C (en) 2023-09-05
AU2015352743A1 (en) 2017-06-08
EP4368990A3 (en) 2024-08-07
MX2017006970A (en) 2018-03-01
SG11201704015RA (en) 2017-06-29
IL277068B (en) 2021-10-31
IL252484B (en) 2020-09-30
NZ731825A (en) 2024-02-23
EP3748358B1 (en) 2023-12-27
EP3120153B1 (en) 2020-08-19
JP2020058360A (en) 2020-04-16
US20170322199A1 (en) 2017-11-09
AU2015352743B2 (en) 2020-10-15
AU2020250225B2 (en) 2022-06-30
CA2968608A1 (en) 2016-06-02
IL277068A (en) 2020-10-29
RU2017122187A (en) 2018-12-28
DK3748358T3 (en) 2024-02-26
ES2831834T3 (en) 2021-06-09
RU2017122187A3 (en) 2019-01-17
US20200057051A1 (en) 2020-02-20
CN107109458A (en) 2017-08-29
ES2972368T3 (en) 2024-06-12
AU2020250225A1 (en) 2020-11-05
CN107109458B (en) 2021-10-26
FI3748358T3 (en) 2024-02-14
ZA201703385B (en) 2018-08-29
KR20170094790A (en) 2017-08-21
EP4368990A2 (en) 2024-05-15
US10393731B2 (en) 2019-08-27
PT3120153T (en) 2020-10-20
IL252484A0 (en) 2017-07-31
US20230194502A1 (en) 2023-06-22
EP3120153A1 (en) 2017-01-25
RU2729628C2 (en) 2020-08-11
JP6700276B2 (en) 2020-05-27
PL3120153T3 (en) 2021-02-08
BR112017011012A2 (en) 2018-02-14
BR112017011012B1 (en) 2024-01-16
EP3026122A1 (en) 2016-06-01
JP2022160596A (en) 2022-10-19
WO2016083297A1 (en) 2016-06-02
EP3748358A1 (en) 2020-12-09
KR102421677B1 (en) 2022-07-18
DK3120153T3 (en) 2020-11-09
JP2017535277A (en) 2017-11-30

Similar Documents

Publication Publication Date Title
MX2022003399A (en) Cellular-based method for determining the potency of defibrotide.
CY1123142T1 (en) IMPROVED METHODS FOR THE PRODUCTION OF POSITIVE CELL THERAPEUTICS
CY1121843T1 (en) MAGNESIUM ION STABILIZED RECEPTOR FORMULATIONS
PH12017501481B1 (en) Bicyclic heterocycles as fgfr inhibitors
MX2019005199A (en) Methods for assessing risk using total and specific cell-free dna.
EP3523419A4 (en) Compositions and methods for maintaining cell viability
PH12016500739A1 (en) Inhibitors of the fibrolast growth factor receptor
NZ733807A (en) Protein delivery in primary hematopoietic cells
AR090973A1 (en) USEFUL ANTIBODIES FOR CANCER DIAGNOSIS
WO2017223280A3 (en) Compositions and methods for the delivery of therapeutics
EP3369810A4 (en) Method for producing cell population that includes mesenchymal stem cells, mesenchymal stem cells, cell population, and pharmaceutical composition
MY187050A (en) Cancer cell-specific antibody, anticancer agent, and cancer testing method
MX2016008448A (en) Var2csa-drug conjugates.
BR112019000693A2 (en) mucocharge compositions and methods for use
EP3093661A4 (en) Artificial cell membrane comprising supported lipid bilayer in which metal particle probe having controlled mobility is coupled, and method for analyzing molecular interaction by using same
EP3526341A4 (en) Compositions and methods for disease diagnosis using single cell analysis
MX2015014892A (en) Method for a cell-based drug screening assay and the use thereof.
EP3342858A4 (en) Ror1-positive mesenchymal stem cells and method for preparing same, pharmaceutical composition containing ror1-positive mesenchymal stem cells and method for preparing same, and method for preventing or treating diseases by using ror1-positive mesenchymal stem cells
EP3202885A4 (en) Novel biological activity testing structure for tracking single cell, using gelling agents
MX2017003903A (en) Compositions and methods for inhibiting the biological activity of soluble biomolecules.
IN2014CN04050A (en)
UY34050A (en) NEW ASSOCIATION BETWEEN 4- {3- [CIS-HEXAHYDROCICLOPENTA [C] PIRROL- 2 (1H) -IL] PROPOXI} BENZAMIDA AND AN INHIBITOR OF ACETILCOLINESTERASE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
IL246525B (en) Pomegranate derived cell culture and methods for preparing and using the same
MX2018004829A (en) Methods of measuring factor d activity and potency of factor d inhibitors.
BR112016026905A8 (en) nampt inhibitors, their use and method to determine their presence, pharmaceutical composition, kit, and method to inhibit B cell differentiation into plasma cells