MX2015014892A - Method for a cell-based drug screening assay and the use thereof. - Google Patents
Method for a cell-based drug screening assay and the use thereof.Info
- Publication number
- MX2015014892A MX2015014892A MX2015014892A MX2015014892A MX2015014892A MX 2015014892 A MX2015014892 A MX 2015014892A MX 2015014892 A MX2015014892 A MX 2015014892A MX 2015014892 A MX2015014892 A MX 2015014892A MX 2015014892 A MX2015014892 A MX 2015014892A
- Authority
- MX
- Mexico
- Prior art keywords
- cell
- screening assay
- time
- drug screening
- based drug
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Abstract
The present invention relates to a cell-based drug screening assay comprising the steps of: (i) culturing a cell population in a culturing environment, (ii) defining at least two monitoring points in time in dependency of at least one of the cell types, physiological characteristics of the cells, physiological characteristics of formed-tissue, the mode of action of a drug substance and the culturing environment, (iii) applying drug substances to the cultured cells at least at one treatment point in time, (iv) monitoring of the effect of said drug substance on cells or formed tissues at least at said two monitoring points in time.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13165419.6A EP2796873A1 (en) | 2013-04-25 | 2013-04-25 | Method for a cell-based drug screening assay and the use thereof |
PCT/EP2014/058152 WO2014173907A1 (en) | 2013-04-25 | 2014-04-22 | Method for a cell-based drug screening assay and the use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015014892A true MX2015014892A (en) | 2016-03-07 |
MX366369B MX366369B (en) | 2019-07-05 |
Family
ID=48326111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015014892A MX366369B (en) | 2013-04-25 | 2014-04-22 | Method for a cell-based drug screening assay and the use thereof. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20160077081A1 (en) |
EP (2) | EP2796873A1 (en) |
JP (1) | JP6484219B2 (en) |
KR (1) | KR102255944B1 (en) |
CN (1) | CN105143883B (en) |
AU (1) | AU2014257584B2 (en) |
BR (1) | BR112015026601B1 (en) |
CA (1) | CA2910146C (en) |
ES (1) | ES2729341T3 (en) |
IL (1) | IL242172B (en) |
MX (1) | MX366369B (en) |
RU (1) | RU2702643C2 (en) |
SG (1) | SG11201508611WA (en) |
WO (1) | WO2014173907A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
JP6804438B2 (en) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | An in vivo model of the human small intestine using pluripotent stem cells, and methods for making and using it. |
JP2016136848A (en) * | 2015-01-26 | 2016-08-04 | 富士フイルム株式会社 | Chemical evaluating method and chemical screening method |
GB201514864D0 (en) * | 2015-08-20 | 2015-10-07 | Insphero Ag | An in vitro 3D cell culture model-based tumor relapse assay |
US11066650B2 (en) | 2016-05-05 | 2021-07-20 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
KR101916801B1 (en) * | 2016-08-12 | 2018-11-08 | 경북대학교 산학협력단 | A drug screening method for diseases associated choroidal neovascularization using biomimetic three dimensional in vitro system |
IT201600099380A1 (en) * | 2016-10-04 | 2018-04-04 | Univ Bologna Alma Mater Studiorum | COMPOSITIONS, DEVICES AND METHODS FOR IN VITRO CONTROL OF THE CHEMICAL CELL CROPS MICRO-ENVIRONMENT |
CA3045145A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
WO2020071484A1 (en) * | 2018-10-05 | 2020-04-09 | 国立大学法人名古屋大学 | Method for screening for chemical substance, program, control device, and culture observation device |
GB201818885D0 (en) * | 2018-11-20 | 2019-01-02 | Precomb Therapeutics Ag | 3d human cancer model-based combinatiorial drug development method |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5728541A (en) * | 1996-07-12 | 1998-03-17 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
DE60220893T2 (en) * | 2001-04-03 | 2008-03-06 | Biocept, Inc., San Diego | METHOD AND GEL COMPOSITIONS FOR CAPTIVATING LIVING CELLS AND ORGANIC MOLECULES |
AU2005253923A1 (en) * | 2004-06-08 | 2005-12-29 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
US20090324596A1 (en) * | 2008-06-30 | 2009-12-31 | The Trustees Of Princeton University | Methods of identifying and treating poor-prognosis cancers |
ES2401640T3 (en) | 2008-09-22 | 2013-04-23 | University Of Zurich Prorektorat Forschung | Hanging Drop Plate |
WO2010083385A2 (en) * | 2009-01-15 | 2010-07-22 | The General Hospital Corporation | Compounds for reducing drug resistance and uses thereof |
US20110004414A1 (en) * | 2009-06-06 | 2011-01-06 | Ceetox, Inc. | Method for Predicting Respiratory Toxicity of Compounds |
EP2380920A1 (en) * | 2010-04-22 | 2011-10-26 | QGel SA | Hydrogel precursor formulation and production process thereof |
CN103328626B (en) * | 2010-10-06 | 2017-02-08 | 中外制药株式会社 | Cancer stem cell mass and process for production thereof |
WO2013039087A1 (en) * | 2011-09-12 | 2013-03-21 | 国立大学法人 熊本大学 | Method for screening for substance |
-
2013
- 2013-04-25 EP EP13165419.6A patent/EP2796873A1/en not_active Withdrawn
-
2014
- 2014-04-22 SG SG11201508611WA patent/SG11201508611WA/en unknown
- 2014-04-22 US US14/786,637 patent/US20160077081A1/en active Pending
- 2014-04-22 CA CA2910146A patent/CA2910146C/en active Active
- 2014-04-22 EP EP14718624.1A patent/EP2989460B1/en active Active
- 2014-04-22 MX MX2015014892A patent/MX366369B/en active IP Right Grant
- 2014-04-22 WO PCT/EP2014/058152 patent/WO2014173907A1/en active Application Filing
- 2014-04-22 BR BR112015026601-0A patent/BR112015026601B1/en active IP Right Grant
- 2014-04-22 KR KR1020157033467A patent/KR102255944B1/en active IP Right Grant
- 2014-04-22 JP JP2016509438A patent/JP6484219B2/en active Active
- 2014-04-22 RU RU2015150203A patent/RU2702643C2/en active
- 2014-04-22 AU AU2014257584A patent/AU2014257584B2/en active Active
- 2014-04-22 CN CN201480022749.4A patent/CN105143883B/en active Active
- 2014-04-22 ES ES14718624T patent/ES2729341T3/en active Active
-
2015
- 2015-10-20 IL IL242172A patent/IL242172B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CN105143883A (en) | 2015-12-09 |
EP2989460B1 (en) | 2019-03-06 |
AU2014257584A1 (en) | 2015-11-05 |
CN105143883B (en) | 2018-10-23 |
MX366369B (en) | 2019-07-05 |
KR20160003761A (en) | 2016-01-11 |
CA2910146C (en) | 2024-04-09 |
AU2014257584B2 (en) | 2020-05-14 |
BR112015026601A2 (en) | 2017-07-25 |
JP2016518129A (en) | 2016-06-23 |
CA2910146A1 (en) | 2014-10-30 |
EP2796873A1 (en) | 2014-10-29 |
KR102255944B1 (en) | 2021-05-25 |
ES2729341T3 (en) | 2019-10-31 |
EP2989460A1 (en) | 2016-03-02 |
US20160077081A1 (en) | 2016-03-17 |
BR112015026601B1 (en) | 2023-11-21 |
WO2014173907A1 (en) | 2014-10-30 |
IL242172B (en) | 2019-03-31 |
RU2702643C2 (en) | 2019-10-09 |
RU2015150203A (en) | 2017-05-31 |
SG11201508611WA (en) | 2015-11-27 |
JP6484219B2 (en) | 2019-03-13 |
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