MX2022001680A - Proteinas de fusion contra glucoesfingolipidos sialosilados y glucoproteinas sialiladas, y usos de los mismos. - Google Patents
Proteinas de fusion contra glucoesfingolipidos sialosilados y glucoproteinas sialiladas, y usos de los mismos.Info
- Publication number
- MX2022001680A MX2022001680A MX2022001680A MX2022001680A MX2022001680A MX 2022001680 A MX2022001680 A MX 2022001680A MX 2022001680 A MX2022001680 A MX 2022001680A MX 2022001680 A MX2022001680 A MX 2022001680A MX 2022001680 A MX2022001680 A MX 2022001680A
- Authority
- MX
- Mexico
- Prior art keywords
- fusion proteins
- glycosphingolipids
- glycoproteins
- sialosylated
- sialated
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 5
- 108020001507 fusion proteins Proteins 0.000 title abstract 5
- 102000003886 Glycoproteins Human genes 0.000 title abstract 2
- 108090000288 Glycoproteins Proteins 0.000 title abstract 2
- 150000002339 glycosphingolipids Chemical class 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 229920002306 Glycocalyx Polymers 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 210000004517 glycocalyx Anatomy 0.000 abstract 2
- 210000003712 lysosome Anatomy 0.000 abstract 2
- 230000001868 lysosomic effect Effects 0.000 abstract 2
- -1 monosaccharide sugars Chemical class 0.000 abstract 2
- 102000003952 Caspase 3 Human genes 0.000 abstract 1
- 108090000397 Caspase 3 Proteins 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 210000003463 organelle Anatomy 0.000 abstract 1
- 102000035123 post-translationally modified proteins Human genes 0.000 abstract 1
- 108091005626 post-translationally modified proteins Proteins 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
Abstract
La presente invención se refiere a proteínas de fusión contra un glucocálix, en asociación con varias proteínas humanas con modificación postraduccional vinculadas a líneas de células cancerosas. Las proteínas de fusión de la presente invención son capaces de unirse a glucoesfingolípidos sialilados y glucoproteínas sialiladas, así a como sus constituyentes independientes, los azúcares monosacáridos tales como neu5ac, galnac y gal que constituyen el glucocálix. Los productos reclamados pueden utilizarse para el diagnóstico y tratamiento de diversos cánceres. La apoptosis mediante caspasa 3 tiene lugar en células cancerosas cuando la proteína de fusión, unida a los objetivos, se secuestra en los lisosomas. La proteína de fusión no se observa en ningún otro orgánulo de la célula, excepto los lisosomas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962884585P | 2019-08-08 | 2019-08-08 | |
| PCT/US2020/045481 WO2021026491A1 (en) | 2019-08-08 | 2020-08-07 | Fusion proteins against sialosylated glycosphingolipids and sialated glycoproteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022001680A true MX2022001680A (es) | 2022-03-11 |
Family
ID=72234957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022001680A MX2022001680A (es) | 2019-08-08 | 2020-08-07 | Proteinas de fusion contra glucoesfingolipidos sialosilados y glucoproteinas sialiladas, y usos de los mismos. |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4010012A1 (es) |
| MX (1) | MX2022001680A (es) |
| WO (1) | WO2021026491A1 (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018053468A1 (en) * | 2016-09-19 | 2018-03-22 | The University Of Toledo | Monoclonal igm antibodies from entirely carbohydrate constructs |
-
2020
- 2020-08-07 EP EP20761411.6A patent/EP4010012A1/en active Pending
- 2020-08-07 MX MX2022001680A patent/MX2022001680A/es unknown
- 2020-08-07 WO PCT/US2020/045481 patent/WO2021026491A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4010012A1 (en) | 2022-06-15 |
| WO2021026491A1 (en) | 2021-02-11 |
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