MX2021011401A - Metodo para la deteccion y cuantificacion de fosfomicina y de sus impurezas y/o productos de degradacion. - Google Patents
Metodo para la deteccion y cuantificacion de fosfomicina y de sus impurezas y/o productos de degradacion.Info
- Publication number
- MX2021011401A MX2021011401A MX2021011401A MX2021011401A MX2021011401A MX 2021011401 A MX2021011401 A MX 2021011401A MX 2021011401 A MX2021011401 A MX 2021011401A MX 2021011401 A MX2021011401 A MX 2021011401A MX 2021011401 A MX2021011401 A MX 2021011401A
- Authority
- MX
- Mexico
- Prior art keywords
- fosfomycin
- pharmaceutically acceptable
- acceptable salt
- quantification
- impurities
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000007857 degradation product Substances 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title abstract 2
- 239000012535 impurity Substances 0.000 title abstract 2
- 238000011002 quantification Methods 0.000 title abstract 2
- YMDXZJFXQJVXBF-STHAYSLISA-N fosfomycin Chemical compound C[C@@H]1O[C@@H]1P(O)(O)=O YMDXZJFXQJVXBF-STHAYSLISA-N 0.000 abstract 6
- 229960000308 fosfomycin Drugs 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/30—Partition chromatography
- B01D15/305—Hydrophilic interaction chromatography [HILIC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/64—Electrical detectors
- G01N2030/645—Electrical detectors electrical conductivity detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8447—Nebulising, aerosol formation or ionisation
- G01N2030/8452—Generation of electrically charged aerosols or ions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/64—Electrical detectors
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invención se refiere a un método para la detección y cuantificación de fosfomicina y de sus impurezas y/o productos de degradación en muestras de fosfomicina o una sal de la misma farmacéuticamente aceptable o en composiciones farmacéuticas que comprenden fosfomicina o una sal de la misma farmacéuticamente aceptable. La presente invención además se refiere a un proceso de fabricación de fosfomicina o una sal de la misma farmacéuticamente aceptable que tiene un grado de pureza especificada, así como a la fosfomicina o una sal de la misma farmacéuticamente aceptable obtenidas. La presente invención además se refiere a un proceso de fabricación de una composición farmacéutica que comprende fosfomicina o una sal de la misma farmacéuticamente aceptable y al menos un excipiente farmacéuticamente aceptable que tiene un grado de pureza especificada, así como a la composición farmacéutica obtenida.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201930256A ES2784076B2 (es) | 2019-03-21 | 2019-03-21 | Metodo para la deteccion y cuantificacion de fosfomicina y de sus impurezas y/o productos de degradacion |
PCT/EP2020/056327 WO2020187644A1 (en) | 2019-03-21 | 2020-03-10 | Method for the detection and quantification of fosmomycin, impurities and degradation products thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021011401A true MX2021011401A (es) | 2022-02-11 |
Family
ID=69810825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021011401A MX2021011401A (es) | 2019-03-21 | 2020-03-10 | Metodo para la deteccion y cuantificacion de fosfomicina y de sus impurezas y/o productos de degradacion. |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220146470A1 (es) |
CA (1) | CA3132408A1 (es) |
ES (2) | ES2784076B2 (es) |
MX (1) | MX2021011401A (es) |
WO (1) | WO2020187644A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102353452B1 (ko) * | 2020-12-23 | 2022-01-21 | 한국과학기술원 | 에어로졸화된 비말 검출장치 |
CN113406259A (zh) * | 2021-05-28 | 2021-09-17 | 海南海灵化学制药有限公司 | 一种拉氧头孢钠杂质的检测方法 |
CN115097051B (zh) * | 2022-07-27 | 2023-03-24 | 广州艾奇西新药研究有限公司 | 一种使用高效液相色谱分离检测磷霉素钠及其制剂中有关物质的方法 |
CN115798573B (zh) * | 2023-02-02 | 2023-05-09 | 武汉宏韧生物医药股份有限公司 | 一种药物成分分析方法及装置 |
CN117213385A (zh) * | 2023-10-10 | 2023-12-12 | 江苏神力特生物科技股份有限公司 | 一种检测和定量牛樟芝固态发酵物中的安卓奎诺尔的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9441053B2 (en) * | 2013-07-11 | 2016-09-13 | Scinopharm Taiwan, Ltd. | Analytical method for detecting sulfated oligosaccharides |
GB201417341D0 (en) * | 2014-10-01 | 2014-11-12 | Isis Innovation | Chromatography |
-
2019
- 2019-03-21 ES ES201930256A patent/ES2784076B2/es active Active
-
2020
- 2020-03-10 MX MX2021011401A patent/MX2021011401A/es unknown
- 2020-03-10 ES ES202190053A patent/ES2872674B2/es active Active
- 2020-03-10 CA CA3132408A patent/CA3132408A1/en active Pending
- 2020-03-10 US US17/441,551 patent/US20220146470A1/en active Pending
- 2020-03-10 WO PCT/EP2020/056327 patent/WO2020187644A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20220146470A1 (en) | 2022-05-12 |
ES2784076A1 (es) | 2020-09-21 |
ES2872674R1 (es) | 2022-07-21 |
ES2872674B2 (es) | 2023-06-29 |
ES2784076B2 (es) | 2021-04-12 |
CA3132408A1 (en) | 2020-09-24 |
ES2872674A2 (es) | 2021-11-02 |
WO2020187644A1 (en) | 2020-09-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2021011401A (es) | Metodo para la deteccion y cuantificacion de fosfomicina y de sus impurezas y/o productos de degradacion. | |
AR125321A2 (es) | Compuesto cristalino, método de preparación y composición que lo comprende | |
PH12020551089A1 (en) | Pyrrolopyrimidine compounds used as tlr7 agonist | |
SA517390509B1 (ar) | مركب مشتق ثلاثي الحلقات، وطريقة لتحضيره ، وتركيبة صيدلانية تشتمل عليه | |
CN106536480A8 (zh) | 吡咯烷‑2,5‑二酮衍生物、药物组合物及用作ido1抑制剂的方法 | |
WO2008086014A3 (en) | Bis-aryl amide derivatives useful for the treatment of cancer | |
HK1116161A1 (en) | Substituted amide derivatives as protein kinase inhibitors | |
WO2007048070A3 (en) | Pyrrolo-pyridine derivatives for the treatment of cancer diseases | |
PH12019502093A1 (en) | Novel ester compounds, method for the production thereof and use thereof | |
MX2022015106A (es) | Proceso para preparar tapinarof. | |
NZ749427A (en) | Thiophene, manufacturing method thereof, and pharmaceutical application of same | |
WO2018118791A3 (en) | Novel quinazolinones that inhibit the formation of tau oligomers and their method of use | |
PH12017501397B1 (en) | (2s, 4r)-5-(5`-chloro-2`-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor | |
WO2016092561A3 (en) | Novel polymorphs of ivacaftor, process for its preparation and pharmaceutical composition thereof | |
WO2009153305A3 (en) | Pharmaceutical compositions of montelukast sodium | |
WO2013190455A3 (en) | Process for the preparation of lurasidone hydrochloride | |
WO2016139683A3 (en) | Pharmaceutical compositions of lurasidone and process for preparing the same | |
MX2023009372A (es) | Proceso para la preparacion de compuestos enlazantes de farmaco. | |
WO2017064635A3 (en) | Saroglitazar magnesium, compositions containing it, process for its preparation | |
GB202016450D0 (en) | Pharmaceutical compositions with low amounts of nitrosamine impurities and methods for producing the same | |
WO2018060962A3 (en) | Metformin amino acid compounds and methods of using the same | |
WO2017093866A3 (en) | An improved process for the preparation of indigo carmine | |
WO2017034242A3 (ko) | 신규한 카테콜 유도체 및 이를 포함하는 약학적 조성물 | |
PH12017501828A1 (en) | Stabilized pharmaceutical composition and method for preparing same | |
WO2012038971A3 (en) | Novel polymorphs of febuxostat |