MX2021004657A - Sistema y metodo para determinar la desamidacion e inmunogenicidad de los polipeptidos. - Google Patents

Sistema y metodo para determinar la desamidacion e inmunogenicidad de los polipeptidos.

Info

Publication number
MX2021004657A
MX2021004657A MX2021004657A MX2021004657A MX2021004657A MX 2021004657 A MX2021004657 A MX 2021004657A MX 2021004657 A MX2021004657 A MX 2021004657A MX 2021004657 A MX2021004657 A MX 2021004657A MX 2021004657 A MX2021004657 A MX 2021004657A
Authority
MX
Mexico
Prior art keywords
dimensional
deamidation
asynchronous
peptoids
peptides
Prior art date
Application number
MX2021004657A
Other languages
English (en)
Inventor
Isao Noda
Belinda Pastrana-Rios
Original Assignee
Protein Dynamic Solutions Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protein Dynamic Solutions Inc filed Critical Protein Dynamic Solutions Inc
Publication of MX2021004657A publication Critical patent/MX2021004657A/es

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Molecular Biology (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Signal Processing (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)

Abstract

Las características de proteínas, péptidos y/o peptoides pueden determinarse mediante espectroscopía de correlación bidimensional y/o espectroscopias de co-distribución bidimensional. Los datos espectrales de las proteínas, péptidos y/o peptoides pueden obtenerse con respecto a un estrés aplicado, tal como estrés térmico. La espectroscopia de correlación bidimensional puede utilizarse para generar gráficas bidimensionales síncronas y asíncronas. La gráfica asíncrona proporciona una resolución mejorada y el orden secuencial de los eventos moleculares que ocurren como una función del estrés aplicado. Los picos pueden identificarse en la gráfica asíncrona, y la correlación de picos que exhiben cambios de intensidad fuera de fase puede utilizarse para determinar la existencia y el grado de eventos de desamidación.
MX2021004657A 2018-10-24 2019-10-24 Sistema y metodo para determinar la desamidacion e inmunogenicidad de los polipeptidos. MX2021004657A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862750022P 2018-10-24 2018-10-24
PCT/US2019/057856 WO2020086845A1 (en) 2018-10-24 2019-10-24 System and method for determining deamidation and immunogenicity of polypeptides

Publications (1)

Publication Number Publication Date
MX2021004657A true MX2021004657A (es) 2021-09-08

Family

ID=70332078

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021004657A MX2021004657A (es) 2018-10-24 2019-10-24 Sistema y metodo para determinar la desamidacion e inmunogenicidad de los polipeptidos.

Country Status (9)

Country Link
US (1) US20210391030A1 (es)
EP (1) EP3870193A4 (es)
JP (1) JP2022507014A (es)
KR (1) KR20210080456A (es)
CN (1) CN113196405A (es)
AU (1) AU2019364440A1 (es)
CA (1) CA3117339A1 (es)
MX (1) MX2021004657A (es)
WO (1) WO2020086845A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023159011A1 (en) * 2022-02-15 2023-08-24 Protein Dynamic Solutions, Inc. Real-time bioburden and direct endotoxin screening

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8268628B1 (en) * 2007-04-13 2012-09-18 University Of Puerto Rico Method for determination of protein, peptide or peptoid aggregation, stability, and viability and system using the same
CN104076115B (zh) * 2014-06-26 2015-12-30 云南民族大学 基于峰强度识别能力的蛋白质二级质谱鉴定方法
CN115308145A (zh) * 2016-01-21 2022-11-08 蛋白质动态解决方案有限公司 用于光谱数据分析的方法和系统
AU2018282883B2 (en) * 2017-06-12 2024-03-28 Protein Dynamic Solutions, Inc. Method and system for analysis of crystals and crystallization

Also Published As

Publication number Publication date
EP3870193A4 (en) 2022-07-20
CN113196405A (zh) 2021-07-30
WO2020086845A1 (en) 2020-04-30
KR20210080456A (ko) 2021-06-30
JP2022507014A (ja) 2022-01-18
CA3117339A1 (en) 2020-04-30
EP3870193A1 (en) 2021-09-01
AU2019364440A1 (en) 2021-05-20
US20210391030A1 (en) 2021-12-16

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