MX2020011575A - Un sistema mejorado de interrogacion de masa de baja energia y ensayo para determinar niveles de vitamina d. - Google Patents

Un sistema mejorado de interrogacion de masa de baja energia y ensayo para determinar niveles de vitamina d.

Info

Publication number
MX2020011575A
MX2020011575A MX2020011575A MX2020011575A MX2020011575A MX 2020011575 A MX2020011575 A MX 2020011575A MX 2020011575 A MX2020011575 A MX 2020011575A MX 2020011575 A MX2020011575 A MX 2020011575A MX 2020011575 A MX2020011575 A MX 2020011575A
Authority
MX
Mexico
Prior art keywords
assay
levels
power mass
improved low
interrogation system
Prior art date
Application number
MX2020011575A
Other languages
English (en)
Inventor
Noah Peter Christian
Original Assignee
Leidos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leidos Inc filed Critical Leidos Inc
Publication of MX2020011575A publication Critical patent/MX2020011575A/es

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0022—Portable spectrometers, e.g. devices comprising independent power supply, constructional details relating to portability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/025—Detectors specially adapted to particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/067—Ion lenses, apertures, skimmers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/20—Magnetic deflection
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/24—Vacuum systems, e.g. maintaining desired pressures
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0013—Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/28—Static spectrometers
    • H01J49/30—Static spectrometers using magnetic analysers, e.g. Dempster spectrometer
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/44—Energy spectrometers, e.g. alpha-, beta-spectrometers
    • H01J49/46—Static spectrometers
    • H01J49/48—Static spectrometers using electrostatic analysers, e.g. cylindrical sector, Wien filter

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plasma & Fusion (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Un montaje de espectrómetro de masas de baja energía incluye al menos un componente de ionización, un analizador electrostático, un montaje de lente, un montaje de imán y al menos un detector ubicado en un mismo plano que la entrada al montaje de imán para detectar los iones de muestra desviados y/o fragmentos de iones de muestra, incluidos iones o fragmentos de iones indicativos del metabolito de vitamina D dentro de la muestra.
MX2020011575A 2018-04-30 2019-04-30 Un sistema mejorado de interrogacion de masa de baja energia y ensayo para determinar niveles de vitamina d. MX2020011575A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862664636P 2018-04-30 2018-04-30
PCT/US2019/029991 WO2019213130A2 (en) 2018-04-30 2019-04-30 An improved low-power mass interrogation system and assay for determining vitamin d levels

Publications (1)

Publication Number Publication Date
MX2020011575A true MX2020011575A (es) 2021-01-20

Family

ID=68291607

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020011575A MX2020011575A (es) 2018-04-30 2019-04-30 Un sistema mejorado de interrogacion de masa de baja energia y ensayo para determinar niveles de vitamina d.

Country Status (5)

Country Link
US (2) US11227754B2 (es)
AU (2) AU2019263158B2 (es)
CA (2) CA3097198A1 (es)
MX (1) MX2020011575A (es)
WO (1) WO2019213130A2 (es)

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1398135A (fr) 1964-03-27 1965-05-07 Commissariat Energie Atomique Procédé de stabilisation de sources thermoioniques et source thermoionique conforme à celles obtenues par application dudit procédé ou d'un procédé analogue
DE1498551A1 (de) * 1964-09-04 1969-03-27 Varian Mat Gmbh Massenspektroskop
GB1153167A (en) 1966-12-28 1969-05-29 Ass Elect Ind Improvements in or relating to aperture devices for mass spectrometers
JPS5917500B2 (ja) 1981-03-18 1984-04-21 株式会社東芝 中性粒子検出装置
US4785172A (en) 1986-12-29 1988-11-15 Hughes Aircraft Company Secondary ion mass spectrometry system and method for focused ion beam with parallel ion detection
GB9026777D0 (en) * 1990-12-10 1991-01-30 Vg Instr Group Mass spectrometer with electrostatic energy filter
US6002130A (en) * 1991-09-12 1999-12-14 Hitachi, Ltd. Mass spectrometry and mass spectrometer
US5317151A (en) * 1992-10-30 1994-05-31 Sinha Mahadeva P Miniaturized lightweight magnetic sector for a field-portable mass spectrometer
US5481110A (en) 1993-09-22 1996-01-02 Westinghouse Electric Corp Thin film preconcentrator array
EP0898784A4 (en) 1996-04-12 2006-08-02 Perkin Elmer Corp ION DETECTOR, DETECTOR SYSTEM AND INSTRUMENT USING SAME
WO1999017865A1 (en) * 1997-10-07 1999-04-15 University Of Washington Magnetic separator for linear dispersion and method for producing the same
US6452167B1 (en) 1998-05-20 2002-09-17 Sandia National Laboratories Miniature quadrupole mass spectrometer having a cold cathode ionization source
DE10321648A1 (de) * 2003-05-13 2004-12-16 Thermo Electron (Bremen) Gmbh Verfahren und Vorrichtung für die massenspektrometrische Analyse von Gasen
WO2005088671A2 (en) 2004-03-05 2005-09-22 Oi Corporation Gas chromatograph and mass spectrometer
US7402799B2 (en) 2005-10-28 2008-07-22 Northrop Grumman Corporation MEMS mass spectrometer
US7649171B1 (en) 2007-05-21 2010-01-19 Northrop Grumman Corporation Miniature mass spectrometer for the analysis of biological small molecules
US20100282966A1 (en) 2008-05-30 2010-11-11 DH Technologies Development Pte Ltd. Method and system for vacuum driven mass spectrometer interface with adjustable resolution and selectivity
FR2942072B1 (fr) 2009-02-06 2011-11-25 Cameca Spectrometre de masse magnetique achromatique a double focalisation.
US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
CN103415909B (zh) 2011-01-05 2016-02-03 普度研究基金会 用于样品分析的系统和方法
CN105869982B (zh) * 2011-02-14 2018-06-01 麻省理工学院 用于质谱分析的方法、装置及系统
GB201114573D0 (en) 2011-08-23 2011-10-05 Univ Sheffield Hallam Categorisation of biological deposits using matrix assisted laser desorption ionisation mass spectrometry
GB2561998A (en) 2012-10-10 2018-10-31 California Inst Of Techn Mass spectrometer, system comprising the same, and methods for determining isotopic anatomy of compounds
LU92130B1 (en) 2013-01-11 2014-07-14 Ct De Rech Public Gabriel Lippmann Mass spectrometer with optimized magnetic shunt
WO2014182333A1 (en) 2013-05-09 2014-11-13 Fomani Arash Akhavan Vacuum pumps for producing adsorbate-free surfaces
CN108872614B (zh) * 2013-09-17 2022-06-21 生物梅里埃公司 用于从维生素d结合蛋白解离维生素d的溶液、相关的检测方法及用途
US10656157B2 (en) 2014-09-24 2020-05-19 Purdue Research Foundation Rare event detection using mass tags
US20170131247A1 (en) 2015-11-09 2017-05-11 Thermo Finnigan Llc Minimal Spanning Trees for Extracted Ion Chromatograms
US10872755B2 (en) 2016-03-17 2020-12-22 Leidos, Inc. Low power mass analyzer and system integrating same for chemical analysis
US10515789B2 (en) * 2017-03-28 2019-12-24 Thermo Finnigan Llc Reducing detector wear during calibration and tuning

Also Published As

Publication number Publication date
WO2019213130A3 (en) 2019-12-19
AU2019263158A1 (en) 2020-11-19
CA3222677A1 (en) 2019-11-07
AU2019263158B2 (en) 2023-12-14
WO2019213130A2 (en) 2019-11-07
US11227754B2 (en) 2022-01-18
US20190333747A1 (en) 2019-10-31
US20220093376A1 (en) 2022-03-24
AU2023274139A1 (en) 2023-12-21
CA3097198A1 (en) 2019-11-07
US11967495B2 (en) 2024-04-23

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MX2020011575A (es) Un sistema mejorado de interrogacion de masa de baja energia y ensayo para determinar niveles de vitamina d.