MX2020007098A - Inhibicion por pic1 de la actividad oxidativa de la mieloperoxidasa en un modelo animal. - Google Patents
Inhibicion por pic1 de la actividad oxidativa de la mieloperoxidasa en un modelo animal.Info
- Publication number
- MX2020007098A MX2020007098A MX2020007098A MX2020007098A MX2020007098A MX 2020007098 A MX2020007098 A MX 2020007098A MX 2020007098 A MX2020007098 A MX 2020007098A MX 2020007098 A MX2020007098 A MX 2020007098A MX 2020007098 A MX2020007098 A MX 2020007098A
- Authority
- MX
- Mexico
- Prior art keywords
- pic1
- subject
- myeloperoxidase
- inhibition
- animal model
- Prior art date
Links
- 102000003896 Myeloperoxidases Human genes 0.000 title abstract 3
- 108090000235 Myeloperoxidases Proteins 0.000 title abstract 3
- 101100243951 Caenorhabditis elegans pie-1 gene Proteins 0.000 title 1
- 238000010171 animal model Methods 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000001590 oxidative effect Effects 0.000 title 1
- 101100153168 Arabidopsis thaliana TIC21 gene Proteins 0.000 abstract 4
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 abstract 4
- 101100273813 Homo sapiens CDKN1A gene Proteins 0.000 abstract 4
- 108700038981 SUMO-1 Proteins 0.000 abstract 4
- 101100083337 Schizosaccharomyces pombe (strain 972 / ATCC 24843) pic1 gene Proteins 0.000 abstract 4
- 208000007587 Transfusion-Related Acute Lung Injury Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000004154 complement system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/00033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Wood Science & Technology (AREA)
- Peptides Or Proteins (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se proporciona un método para tratar lupus eritematoso sistémico en un sujeto en el cual una cantidad terapéuticamente eficaz de PIC1 se administra al sujeto. También se proporciona un método para el tratamiento de la lesión pulmonar aguda relacionada con la transfusión, donde se administra una cantidad terapéuticamente eficaz de PIC1 al sujeto. PIC1 puede modular la activación del sistema del complemento por el complejo inmune y la formación de NET en el sujeto. PIC1 puede también inhibir la actividad de mieloperoxidasa (MPO) en el sujeto.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862615183P | 2018-01-09 | 2018-01-09 | |
| US201862681458P | 2018-06-06 | 2018-06-06 | |
| US201862746649P | 2018-10-17 | 2018-10-17 | |
| PCT/US2019/012659 WO2019139886A1 (en) | 2018-01-09 | 2019-01-08 | Pic1 inhibition of myeloperoxidase oxidative activity in an animal model |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020007098A true MX2020007098A (es) | 2020-11-11 |
Family
ID=67140101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020007098A MX2020007098A (es) | 2018-01-09 | 2019-01-08 | Inhibicion por pic1 de la actividad oxidativa de la mieloperoxidasa en un modelo animal. |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11135272B2 (es) |
| EP (1) | EP3740074A4 (es) |
| JP (2) | JP7031011B2 (es) |
| KR (2) | KR102420552B1 (es) |
| CN (1) | CN112512548A (es) |
| AU (2) | AU2019207508B2 (es) |
| CA (1) | CA3086407A1 (es) |
| IL (2) | IL287308B2 (es) |
| MX (1) | MX2020007098A (es) |
| SG (1) | SG11202006063RA (es) |
| WO (1) | WO2019139886A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10947279B2 (en) | 2015-06-26 | 2021-03-16 | Realta Holdings, Llc | Synthetic peptide compounds and methods of use |
| WO2022072272A2 (en) * | 2020-09-30 | 2022-04-07 | Realta Life Sciences, Inc. | Peptides and methods of use |
| MX2023005395A (es) * | 2020-11-09 | 2023-05-19 | Realta Life Sciences Inc | Formulaciones de peptidos y metodos de uso. |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5625049A (en) | 1993-05-12 | 1997-04-29 | Us Health | Nucleic acids encoding human astrovirus serotype 2 |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| AU3066699A (en) | 1998-03-03 | 1999-09-20 | Johns Hopkins University, The | Smallpox inhibitor of complement enzymes (spice) protein and methods of inhibiting complement activation |
| AU2729400A (en) | 1999-01-19 | 2000-08-07 | James Daly | Application of a viral complement inhibitory protein in the treatment and diagnosis of alzheimer's disease |
| US6696562B1 (en) | 2000-07-10 | 2004-02-24 | The United States Of America As Represented By The Secretary Of Agriculture | Avian astrovirus |
| US20070116672A1 (en) | 2003-09-05 | 2007-05-24 | Kotwal Girish J | Treatment of rheumatic diseases |
| WO2005023195A2 (en) | 2003-09-05 | 2005-03-17 | University Of Louisville Research Foundation, Inc. | Treatment of spinal cord injury |
| DE602004021946D1 (de) | 2003-09-05 | 2009-08-20 | Tonen Sekiyukagaku Kk | Verfahren zur herstellung einer mikroporösen folie aus thermoplastischem harz |
| US8501705B2 (en) | 2003-09-11 | 2013-08-06 | The Board Of Regents Of The University Of Texas System | Methods and materials for treating autoimmune and/or complement mediated diseases and conditions |
| US7381524B2 (en) | 2003-10-10 | 2008-06-03 | Wisconsin Alumni Research Foundation | Method to detect antibodies specific for type-2 turkey astrovirus |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| CA2655371C (en) | 2006-06-15 | 2017-06-20 | Eastern Virginia Medical School | Methods for regulating complement cascade proteins using astrovirus coat protein and derivatives thereof |
| CA2688693A1 (en) | 2007-04-11 | 2008-10-23 | Pestka Biomedical Laboratories, Inc. | Interferons of rhesus and cynomolgus origin and uses thereof |
| US10172950B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
| EP2561367A1 (en) | 2010-04-22 | 2013-02-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Means and methods for identifying an increased risk of systemic lupus erythematosus (sle) patients for developing renal manifestations |
| CA2804998C (en) | 2010-07-21 | 2018-11-13 | Eastern Virginia Medical School | Peptide compounds to regulate the complement system |
| US10005818B2 (en) | 2010-07-21 | 2018-06-26 | Realta Holdings, Llc | Derivative peptide compounds and methods of use |
| EP2838550A1 (en) | 2012-03-16 | 2015-02-25 | Belrose Pharma Inc. | Polymeric conjugates of c1-inhibitors |
| CA2987141A1 (en) * | 2015-06-26 | 2016-12-29 | Eastern Virginia Medical School | Synthetic peptide compounds and methods of use |
-
2019
- 2019-01-08 KR KR1020207022678A patent/KR102420552B1/ko active IP Right Grant
- 2019-01-08 IL IL287308A patent/IL287308B2/en unknown
- 2019-01-08 WO PCT/US2019/012659 patent/WO2019139886A1/en active Application Filing
- 2019-01-08 JP JP2020557135A patent/JP7031011B2/ja active Active
- 2019-01-08 CA CA3086407A patent/CA3086407A1/en active Pending
- 2019-01-08 MX MX2020007098A patent/MX2020007098A/es unknown
- 2019-01-08 AU AU2019207508A patent/AU2019207508B2/en active Active
- 2019-01-08 US US16/242,550 patent/US11135272B2/en active Active
- 2019-01-08 SG SG11202006063RA patent/SG11202006063RA/en unknown
- 2019-01-08 CN CN201980007577.6A patent/CN112512548A/zh active Pending
- 2019-01-08 EP EP19738307.8A patent/EP3740074A4/en active Pending
- 2019-01-08 KR KR1020227023661A patent/KR20220104268A/ko not_active Application Discontinuation
-
2020
- 2020-04-03 US US16/839,464 patent/US11020460B2/en active Active
- 2020-07-06 IL IL275867A patent/IL275867B/en unknown
-
2021
- 2021-04-30 US US17/245,213 patent/US11712462B2/en active Active
-
2022
- 2022-02-22 JP JP2022025426A patent/JP7341268B2/ja active Active
-
2023
- 2023-06-09 US US18/332,026 patent/US20230321201A1/en active Pending
-
2024
- 2024-07-31 AU AU2024205230A patent/AU2024205230A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL287308B2 (en) | 2024-03-01 |
| IL287308A (en) | 2021-12-01 |
| JP2022068323A (ja) | 2022-05-09 |
| EP3740074A4 (en) | 2021-10-13 |
| AU2024205230A1 (en) | 2024-09-05 |
| CN112512548A (zh) | 2021-03-16 |
| US20230321201A1 (en) | 2023-10-12 |
| SG11202006063RA (en) | 2020-07-29 |
| IL275867B (en) | 2022-01-01 |
| KR20200138168A (ko) | 2020-12-09 |
| WO2019139886A1 (en) | 2019-07-18 |
| US11020460B2 (en) | 2021-06-01 |
| CA3086407A1 (en) | 2019-07-18 |
| AU2019207508A1 (en) | 2020-07-09 |
| JP2021509916A (ja) | 2021-04-08 |
| KR102420552B1 (ko) | 2022-07-13 |
| JP7341268B2 (ja) | 2023-09-08 |
| IL287308B1 (en) | 2023-11-01 |
| JP7031011B2 (ja) | 2022-03-07 |
| US11712462B2 (en) | 2023-08-01 |
| AU2019207508B2 (en) | 2024-05-02 |
| US11135272B2 (en) | 2021-10-05 |
| US20190209660A1 (en) | 2019-07-11 |
| KR20220104268A (ko) | 2022-07-26 |
| US20210252113A1 (en) | 2021-08-19 |
| EP3740074A1 (en) | 2020-11-25 |
| IL275867A (en) | 2020-08-31 |
| US20200230212A1 (en) | 2020-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: REALTA HOLDINGS, LLC |